Publications by authors named "Cheng Wu"

Objective: Mitochondria are essential for energy production and reactive oxygen species (ROS) generation, with changes in ROS levels or energy demands affecting mitochondrial DNA (mtDNA) copy numbers, indicating mitochondrial function. Early life adversity (ELA) affects mitochondrial dynamics, influencing long-term health. Both ELA and mitochondrial abnormalities have been independently associated with bipolar disorder (BD).

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The initial phase of an insect's innate immune response to foreign pathogens is triggered by the identification of exogenous invaders, a mechanism facilitated by pattern recognition receptors. Among these receptors, peptidoglycan recognition proteins (PGRPs), abundant in insects, are essential components of the innate immune system. The roles of PGRPs have been extensively elucidated in ; however, the mechanism underlying the immune response of to pathogens is unclear.

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Background: Timely and accurate outcome prediction is essential for clinical decision-making for ischemic stroke patients in the intensive care unit (ICU). However, the interpretation and translation of predictive models into clinical applications are equally crucial. This study aims to develop an interpretable machine learning (IML) model that effectively predicts in-hospital mortality for ischemic stroke patients.

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Introduction: This study aimed to identify suitable plants for remediating metal pollution in copper tailing soil and supporting ecological reclamation in Dongchuan, Yunnan, focusing on three major mining regions: Tangdan, Yinmin, and Lanniping.

Methods: The Nemerow comprehensive pollution index was employed to evaluate the metal contamination levels, and the enrichment and transfer capacities of the dominant plants for Cd, Cu, Pb, and Zn were analyzed to identify remediation candidates.

Results: The findings revealed severe pollution in the copper tailing soil, with Cu as the primary pollutant, and with a pollution rate of 77.

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We present direct observations of 2-methyltetrol (CHO) in the gas- and particle phase from the deployment of a Filter Inlet for Gases and Aerosols coupled to a Time-of-Flight Chemical Ionization Mass Spectrometer (FIGAERO-CIMS) during the Southern Hemisphere High Altitude Experiment on Particle Nucleation and Growth (SALTENA), which took place between December 2017 and June 2018 at the high-altitude Global Atmosphere Watch station Chacaltaya (CHC) located at 5240 m a s l in the Bolivian Andes. 2-Methyltetrol signals were dominant in a factor resulting from Positive Matrix Factorization (PMF) identified as influenced by Amazon emissions. We combine these observations with investigations of isoprene oxidation chemistry and uptake in an isolated deep convective cloud in the Amazon using a photochemical box model with coupled cloud microphysics and show that, likely, 2-methyltetrol is taken up by hydrometeors or formed in the convective cloud, and then transported in the particle phase in the cold environment of the Amazon outflow and to the station, where it partially evaporates.

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The accumulation and uniformity of the distribution of the marinade throughout the meat over time is significantly influenced the quality of marinated meat. Based on the commonly used wet-immersion marinating method. Hyperspectral imaging (HSI) was used to quantitatively analyze the diffusion dynamics of NaCl in beef, which has advantages of rapid time dimension and continuous space dimension when acquiring optical signal of samples.

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Large-scale implementation of emerging halide perovskite solar cells (PSCs) has been restrained by environmental and health concerns stemming from the use of lead in their composition. In contrast, tin perovskite solar cells (TPSCs) have been widely recognized as viable alternatives owing to their ideal optical band gap, high carrier mobility and excellent optoelectronic properties. However, TPSCs encounter significant open-circuit voltage () deficits due to the spontaneous oxidation of Sn and uncontrolled crystallization process.

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Optical information synthesis, which fuses LiDAR and optical cameras, has the potential for highly detailed 3D representations. However, due to the disparity of information density between point clouds and images, conventional matching methods based on points often lose significant information. To address this issue, we propose a regional matching method to bridge the differences in information density between point clouds and images.

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Article Synopsis
  • Lead-free tin halide perovskite solar cells have made strides in power conversion efficiency but face limitations from energy level mismatches and weak interactions with electron transport materials.
  • A new fluorinated fullerene derivative (C-FTPA) was developed to enhance the electron transport material when combined with a previously studied derivative (C-ETPA).
  • This new binary electron transport material showed improved molecular structure and interactions, leading to a notable increase in power conversion efficiency, reaching 11.93%.
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Curcumin, a compound from Curcuma longa L., has significant anti-inflammatory properties. However, the mechanisms underlying its anti-inflammatory activity in dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) remain inadequately understood.

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Acute kidney injury (AKI) has become a disease of global concern due to its high morbidity and mortality. This has highlighted the need for renoprotective agents. Astragaloside IV (AS-IV) is a saponin isolated from Astragalus membranaceus with good antioxidant, anti-inflammatory and anti-tumor properties.

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Background: Modern pancreatic surgery has gradually changed with the introduction of neoadjuvant therapy. For patients with pancreatic cancer involving peripancreatic visceral arteries who have received neoadjuvant therapy, periarterial divestment has gradually gained popularity, which represents an alternative to arterial resection. There is ongoing debate about whether this approach achieves curative tumor resection comparable to that of arterial resection, and the differences in terms of postoperative complications and oncologic outcomes between the 2 surgical procedures.

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NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) protein is located in the mitochondria and can regulate cell proliferation. Some studies have shown that the high NDUFA4L2 expression is linked with poor prognosis and cancer progression in various patients with cancers. However, the correlation between NDUFA4L2 and pan-cancer is unknown.

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Background: Sarcopenia is a prevalent condition associated with aging. Inflammation and pyroptosis significantly contribute to sarcopenia.

Methods: Two sarcopenia-related datasets (GSE111016 and GSE167186) were obtained from the Gene Expression Omnibus (GEO), followed by batch effect removal post-merger.

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The airing process of sauce-flavor Baijiu is a critical operation that serves the functions of cooling, homogenizing, and facilitating microbial proliferation and metabolism. Comprehensive analysis of physicochemical parameters, bacterial and fungal community of fermented grains, and volatile flavor compounds of soy-sauce (Jiangxiang) and mellow-sweet (Chuntian) typical base liquors among traditional (CT) and two different mechanized (JXA and JXB) airing operations were investigated. The results indicated that the dynamic variation patterns of moisture content, total titratable acidity, starch content, lactic acid, acetic acid, pH, and dominated microbial composition among CT, JXA, and JXB were similar, while minor bacterial genera with relative abundance including unclassified Micrococcineae, unclassified Rhizobiales, etc, and dominated fungi such as Torulaspora, Hyphopichia, Candida, Pichia, and Penicillium were profoundly influenced by mechanized airing operations, especially by JXB.

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The interfacial photothermal-photocatalytic systems can generate clean water while purifying wastewater containing organic pollutants, but the impact of thermal convection on synergistic effects remains unexplored. This paper aims to regulate the thermal convection at the interface to significantly enhance the synergistic effect of interfacial photothermal-photocatalytic systems. A novel heterogeneous structure comprising iron-based metal-organic frameworks and multi-walled carbon nanotubes with a gelatin-polyvinyl alcohol (PVA) double network hydrogel (MWCNTs@NM88B/PVA/gelatin hydrogel, denoted as MMH) is developed and employed in the construction of the solar-driven interfacial evaporation (SIE) system.

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Article Synopsis
  • * The experimental group received cBMMSC-infused conduits, while the control group had conduits without these cells; both groups were evaluated for neuron-like cell differentiation, neuronal regeneration, and axon growth after four weeks.
  • * Various methods, including immunostaining and Western blotting, were employed to assess neural recovery and functional outcomes, such as motor ability and nerve impulse transmission, in both groups.
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  • - Cognitive difficulties in bipolar disorder (BD) may be linked to insulin resistance, which impacts metabolism and brain health; mitochondrial DNA (mtDNA) copy number is suggested as a potential marker for cognitive performance and treatment response.
  • - A study with 68 participants found that insulin resistance indirectly influences executive function through its effect on mtDNA copy number, with significant relationships identified in tasks measuring preservation errors and category completion on the Wisconsin card-sorting test (WCST).
  • - The findings indicate that lower mtDNA copy number, associated with higher insulin resistance, may lead to poorer cognitive functions in patients with euthymic BD; further research is needed to explore how improving metabolic health could enhance cognitive outcomes.
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  • Stroke recurrence readmission can heavily impact patients and healthcare systems, necessitating effective risk stratification to enable targeted interventions.* -
  • Researchers analyzed over 339,000 stroke admission episodes from 2015 to 2019, developing the Score for Stroke Recurrence Readmission Prediction (SSRRP) tool based on six key factors to predict readmission risks.* -
  • The SSRRP tool demonstrated a reliable predictive capability with an AUC of 0.730, offering a practical scoring method to help mitigate the chances of patients facing early readmission after a stroke.*
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Objective: Human umbilical cord mesenchymal stem cells (hUCMSCs) hold significant promise across various clinical applications. Therefore, regulatory requirements necessitate a thorough investigation of the hUCMSCs safety before clinical trials and potential allergic reactions after transplantation.

Methods: Abnormal toxicity test employed mice and guinea pigs dosed daily at 0.

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The nocturnal boundary layer (NBL) significantly influences the dispersion and fate of atmospheric species at night. Subtropical forests are crucial in carbon and water exchange between the biosphere and the atmosphere. However, the NBL characteristics and their impact on atmospheric species over these forests remain unknown.

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  • A clinical trial assessed the effectiveness of neoadjuvant chemotherapy using targeted agents for locally advanced rectal cancer patients with specific gene mutations.
  • Patients were randomly assigned to two treatment groups: one receiving chemotherapy with radiotherapy, and the other with the drug cetuximab; both groups later underwent surgery.
  • Results showed no significant differences in the success rates of tumor removal (R0 resection) and other outcomes between the two groups, but the cetuximab group had lower complications, suggesting it may be a better treatment approach.
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  • Food allergies in children are linked to gut microbiota, and fecal microbiota transplantation (FMT) has potential as a treatment, though its effectiveness in this context needs further validation.
  • The study utilized a mouse model to analyze the impacts of FMT on food allergies, finding that it improved gut microbiota diversity and reduced inflammation and allergic responses.
  • The research suggests that FMT promotes immune tolerance through specific immune pathways, hinting at a new therapeutic approach for managing food allergies by restoring gut health.
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The anterior cingulate cortex (ACC) is one of the critical brain areas for processing noxious information. Previous studies showed that peripheral nerve injury induced broad changes in the ACC, contributing to pain hypersensitivity. The neurons in layer 3 (L3) of the ACC receive the inputs from the mediodorsal thalamus (MD) and form the feedforward inhibition (FFI) microcircuits.

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