Forward calculation of airborne gamma 3D radiation fields based on rapid coupling method of point kernel integrals.

Airborne gamma ray spectrum detection technology is an effective means to measure the concentration and spatial distribution of natural radionuclides in environmental media such as surface rocks and soil during aviation flight. Therefore, it is vital to fully explore the radiation information related to mineralization in airborne gamma spectrometry data and explore the dose distribution law of gamma radiation field of radionuclides in the detection area. This paper is based on the theoretical calculation model of ground-air interface gamma radiation field.

Microbial degradation mechanisms, degradation pathways, and genetic engineering for pyrethroids: current knowledge and future perspectives.

Pyrethroids are synthetic products derived from natural pyrethroids present in flowers and are extensively used as pesticides for agriculture, animal husbandry, and household pest control. However, excessive and prolonged usage of pyrethroid insecticides can result in adverse effects on both non-target and target species. Therefore, effective technologies need to be developed to remove pyrethroid contamination and ensure environmental safety.

[Prediction of anti-gastric cancer effect of Panacis Quinquefolii Radix by network pharmacology and in vivo validation].

This study investigated the anti-gastric cancer activity and mechanism of Panacis Quinquefolii Radix(Panax quinquefolium L.), and preliminarily compared the in vivo anti-gastric cancer efficacy of American-imported(JK-AG) and domestically produced(Shandong) Panacis Quinquefolii Radix decoctions(SD-AG). Based on network pharmacology predictions, a LUC-MGC803 cell ectopic gastric cancer nude mouse model was established.

Development and validation of intravoxel incoherent motion diffusion weighted imaging-based model for preoperative distinguishing nuclear grade and survival of clear cell renal cell carcinoma complicated with venous tumor thrombus.

Objective: To assess the utility of multiparametric MRI and clinical indicators in distinguishing nuclear grade and survival of clear cell renal cell carcinoma (ccRCC) complicated with venous tumor thrombus (VTT).

Materials And Methods: This study included 105 and 27 patients in the training and test sets, respectively. Preoperative MRI, including intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI), was performed.

MOMFNet: A Deep Learning Approach for InSAR Phase Filtering Based on Multi-Objective Multi-Kernel Feature Extraction.

Interferometric Synthetic Aperture Radar (InSAR) is a widely used remote sensing technology for Earth observation, enabling the detection and measurement of ground deformation through the generation of interferograms. However, phase noise remains a critical factor that degrades interferogram quality. To address this issue, this study proposes MOMFNet, a deep learning approach for InSAR phase filtering based on multi-objective multi-kernel feature extraction that leverages multi-objective multi-kernel feature extraction.

Ameliorative Effect of Ginsenoside Rc on 5-Fluorouracil-Induced Chemotherapeutic Intestinal Mucositis via the PI3K-AKT/NF-κB Signaling Pathway: In Vivo and In Vitro Evaluations.

5-Fluorouracil (5-Fu) is a chemotherapeutic agent widely used to treat various cancers, which causes intestinal mucositis as a common side effect. Ginsenoside Rc, an active compound with anti-inflammatory, antioxidant, immunomodulatory, and antitumor properties, has protective effects against chemotherapy-induced mucositis caused by 5-Fu. This study aims to evaluate the protective effects of Rc on 5-Fu-induced chemotherapy-related mucositis and to elucidate its underlying mechanisms.

Deubiquitinases as novel therapeutic targets for diseases.

Deubiquitinating enzymes (DUBs) regulate substrate ubiquitination by removing ubiquitin or cleaving within ubiquitin chains, thereby maintaining cellular homeostasis. Approximately 100 DUBs in humans counteract E3 ubiquitin ligases, finely balancing ubiquitination and deubiquitination processes to maintain cellular proteostasis and respond to various stimuli and stresses. Given their role in modulating ubiquitination levels of various substrates, DUBs are increasingly linked to human health and disease.

Social functioning mediated the relationship between childhood emotional neglect and cognitive deficits in patients with schizophrenia.

Background: Childhood maltreatment is frequently reported to be associated with cognitive deficits in patients with schizophrenia, but research on the childhood neglect subtype in childhood maltreatment is limited.

Objective: This study sets out from the impact of childhood neglect on cognitive impairment in schizophrenia, and explores the interrelationship of childhood neglect, social functioning, resilience, and cognitive functioning.

Participants And Setting: Two-hundred and thirty-two patients who met the DSM-IV criteria for schizophrenia were recruited at the Second Xiangya Hospital of Central South University.

Promises of natural products as clinical applications for cancer.

Cancer represents a substantial threat to human health and mortality, necessitating the development of novel pharmacological agents with innovative mechanisms of action. Consequently, extensive research has been directed toward discovering new anticancer compounds derived from natural sources, including plants, microbes, and marine organisms. This review offers a comprehensive analysis of natural anticancer agents that are either currently undergoing clinical trials or have been integrated into clinical practice.

Strong electron-phonon coupling in magic-angle twisted bilayer graphene.

The unusual properties of superconductivity in magic-angle twisted bilayer graphene (MATBG) have sparked considerable research interest. However, despite the dedication of intensive experimental efforts and the proposal of several possible pairing mechanisms, the origin of its superconductivity remains elusive. Here, by utilizing angle-resolved photoemission spectroscopy with micrometre spatial resolution, we reveal flat-band replicas in superconducting MATBG, where MATBG is unaligned with its hexagonal boron nitride substrate.

Complex kinship testing using the MGIEasy Pa-SNPs genotyping kit.

Disaster victim identification and criminal investigations have intensified the demand of complex kinship testing. Compared to close relatives, distant relatives share fewer identical-by-descent genetic segments; therefore, more genetic markers are required to improve the system effectiveness. Driven by the progress of next-generation sequencing, several commercial or in-house panels, including a large number of genetic markers, have been developed and applied in forensic caseworks.

High frequency of melanoma in /.

Melanoma, the deadliest form of skin cancer characterized by high therapy resistance, has undergone extensive investigation through the utilization of BRAF-driven melanoma animal models. However, there exists a paucity of animal models for the rare hereditary melanoma resulting from germline mutations. Here, employing CRISPR/Cas9 technology, we generated on a knockout background to model human germline mutation-induced hereditary melanoma.

Advancements in atmospheric water harvesting: toward continuous operation through mass transfer optimization.

Sorption-based atmospheric water harvesting (SAWH) offers a promising solution to global water scarcity. However, practical implementation is limited by discontinuities in the mass transfer process inside sorbents. This perspective reviews current SAWH technologies and introduces a new concept, mass transfer of SAWH (MT-SAWH), which ensures continuous water collection by facilitating the movement of water molecules within a fixed sorbent bed.

Understanding the superconductivity and charge density wave interaction through quasi-static lattice fluctuations.

In unconventional superconductors, coupled charge and lattice degrees of freedom can manifest in ordered phases of matter that are intertwined. In the cuprate family, fluctuating short-range charge correlations can coalesce into a longer-range charge density wave (CDW) order which is thought to intertwine with superconductivity, yet the nature of the interaction is still poorly understood. Here, by measuring subtle lattice fluctuations in underdoped YBaCuO on quasi-static timescales (thousands of seconds) through X-ray photon correlation spectroscopy, we report sensitivity to both superconductivity and CDW.

Association between serum homocysteine and erectile dysfunction: a systematic review and meta-analysis.

The aim of this meta-analysis was to determine the relationship between erectile dysfunction (ED) and serum homocysteine (Hcy) levels. A comprehensive search was performed using databases such as Web of Science, PubMed, and the Cochrane Library to identify suitable studies published by July 2023. The statistical analysis involved calculating the standardized mean differences (SMDs) and 95% confidence intervals (CIs) using STATA software.

Effect of biodegradable microplastics and Cd co-pollution on Cd bioavailability and plastisphere in soil-plant system.

Biodegradable plastics (BPs) are regarded as ecomaterials and are emerging as a substitute for traditional non-degradable plastics. However, the information on the interaction between biodegradable microplastics (BMPs) and cadmium (Cd) in agricultural soil is still limited. Here, lettuce plants were cultured in BMPs (polylactic acid (PLA) MPs and poly(butylene-adipate-co-terephthalate) (PBAT) MPs) and Cd co-polluted soil for 35 days.

Scalable Melt Polymerization Synthesis of Covalent Organic Framework Films for Room Temperature Low-Concentration SO Detection.

The development of highly efficient sensors for low-concentration SO at room temperature is important for human health and fine chemistry, but it still faces critical challenges. Herein, a scalable olefin-linked covalent organic framework (COF) with an ultramicroporous structure and abundant binding sites is first developed as the SO sensing material. The COF can adsorb SO of 220 cm/g at 1 bar and 40 cm/g at 0.