Long-term outcomes of robot versus video-assisted thymectomy for thymic epithelial tumors: a propensity matched analysis.

Background: Robot-assisted thoracoscopic surgery (RATS) thymectomy has been increasingly performed for treating thymic epithelial tumors in recent years. However, there are very limited reports on the long-term oncologic outcomes after RATS thymectomy, particularly in comparison to Video-assisted thoracoscopic surgery (VATS). This study aimed to compare the perioperative and long-term oncological outcomes between RATS and VATS.

Dynamic Wavelength-Selective Diffraction and Absorption with Direct-Patterned Hydrogel Metagrating.

Hydrogel nanophotonic devices exhibit attractive tunable capabilities in structural coloration and optical display. However, current hydrogel-based tunable strategies are mostly based on a single physical mechanism, and it remains a challenge to merge multiple mechanisms for active devices with integrated functionalities. Here, a hydrogel metagrating combining Fabry-Pérot (FP) resonance and diffraction effects is proposed for achieving tunable absorption and dynamic wavelength-selective beam steering.

Curcumin Attenuates Dextran Sodium Sulfate Induced Colitis in Obese Mice.

Scope: Curcumin (Cur), with diverse pharmacological properties, shows anti-obesity, immunomodulatory, and anti-inflammatory effects. Its role in ulcerative colitis complicated by obesity remains unclear.

Methods And Results: Here, colitis is induced in obese mice using dextran sulfate sodium (DSS), followed by administration of Cur at a dosage of 100 mg kg for 14 days.

Sishen pills inhibit inflammatory dendritic cell differentiation via miR-505-3p mediated E-cadherin downregulation in ulcerative colitis.

Background: Ulcerative colitis (UC) is an autoimmune disease that is highly susceptible to recurrence, which is still a lack of effective drugs with minor side effects in clinic. Intervention of inflammatory differentiation of dendritic cells (DCs) might be an effective strategy to treat UC. Sishen Pills (SSP) is a classic Chinese herbal formula which has been demonstrated the protective effect of UC, but the mechanism remains unclear.

Osr2 functions as a biomechanical checkpoint to aggravate CD8 T cell exhaustion in tumor.

Alterations in extracellular matrix (ECM) architecture and stiffness represent hallmarks of cancer. Whether the biomechanical property of ECM impacts the functionality of tumor-reactive CD8 T cells remains largely unknown. Here, we reveal that the transcription factor (TF) Osr2 integrates biomechanical signaling and facilitates the terminal exhaustion of tumor-reactive CD8 T cells.

Integrating network pharmacology and experimental verification to explore the mucosal protective effect of Chimonanthus nitens Oliv. Leaf Granule on ulcerative colitis.

Ethnopharmacological Relevance: Chimonanthus nitens Oliv. Leaf Granule (COG) is a commonly used clinical preparation of traditional Chinese medicine for the treatment of cold, but there are folk reports that it can treat diarrhea and other gastrointestinal diseases. Therefore, the mechanism of COG in the treatment of ulcerative colitis with diarrhea as the main symptom needs to be studied.

Simultaneous Incorporation of CsI in the Two-step Deposition Process Boosts the Power Conversion Efficiency and Stability of Perovskite Solar Cells.

Two-step deposition method has been widely exploited to fabricate FA Cs PbI perovskite solar cells. However, in previous studies, CsI is mainly added into the PbI precursor with DMF/DMSO as solvent. Here in this study, a novel method to fabricate FA Cs PbI perovskite has been proposed.

SPTAN1/NUMB axis senses cell density to restrain cell growth and oncogenesis through Hippo signaling.

The loss of contact inhibition is a key step during carcinogenesis. The Hippo-Yes-associated protein (Hippo/YAP) pathway is an important regulator of cell growth in a cell density-dependent manner. However, how Hippo signaling senses cell density in this context remains elusive.

Surface Passivation of Perovskite Solar Cells with Oxalic Acid: Increased Efficiency and Device Stability.

Solution processed perovskite films usually exhibit numerous defect states on the surfaces of the films. Here in this work, oxalic acid (H C O ), which has two C=O groups, is selected and used to passivate the surface defects of the two-step deposited perovskite films via post-treatment. Strong interaction between H C O molecule and the Pb ions located on the surface of perovskite film has been confirmed via Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, which can result in an effective suppress of the surface defects.

To be appreciated or to be despised: The role of leader selection and trust in leaders.

To sustainably develop organisational goals, it is important to create conditions under which leaders are trusted and judged to be incorrupt. We proposed that and tested whether leader selection affects judgements of leader corruption. A correlational study with cross-national data and two experimental studies in China were conducted.

Oliv. Leaf Granule Ameliorates DSS-Induced Acute Colitis Through Treg Cell Improvement, Oxidative Stress Reduction, and Gut Microflora Modulation.

The rising incidence of ulcerative colitis has become a new challenge for public health. Oliv. leaf granule (COG) is a natural medicine used for the treatment of respiratory diseases, which has excellent anti-inflammatory and antioxidant effects.

Glycogen accumulation and phase separation drives liver tumor initiation.

Glucose consumption is generally increased in tumor cells to support tumor growth. Interestingly, we report that glycogen accumulation is a key initiating oncogenic event during liver malignant transformation. We found that glucose-6-phosphatase (G6PC) catalyzing the last step of glycogenolysis is frequently downregulated to augment glucose storage in pre-malignant cells.

Association of Malnutrition, as Defined by the PG-SGA, ESPEN 2015, and GLIM Criteria, With Complications in Esophageal Cancer Patients After Esophagectomy.

There are several approaches that can be used for the pre-treatment identification of malnutrition in oncology populations including the Patient-Generated Subjective Global Assessment (PG-SGA), the 2015 consensus statement by the European Society for Clinical Nutrition and Metabolism (ESPEN 2015) and the Global Leadership Initiative on Malnutrition (GLIM). This study aimed to evaluate whether malnutrition, as defined by these three methods, can be used to predict complications in esophageal cancer (EC) patients after esophagectomy. We performed a single center, observational cohort study that included 360 EC patients undergoing esophagectomy from December 2014 to November 2019 at Daping Hospital in China.

Weighted multiple model adaptive boundary control for a flexible manipulator.

In this article, a weighted multiple model adaptive boundary control scheme is proposed for a flexible manipulator with unknown large parameter uncertainties. First, the uncertainties are approximatively covered by a finite number of constant models. Second, based on Euler-Bernoulli beam theory and Hamilton principle, the distributed parameter model of the flexible manipulator is constructed in terms of partial differential equation for each local constant model.

Probing effects of molecular conformation on the electronic and charge transport properties in two- and three-dimensional small molecule hole-transporting materials: a theoretical investigation.

Thiophene/benzene-fused π-conjugated systems are normally employed as the core units of two- and three-dimensionally expanded small molecule hole-transporting materials (HTMs) to improve their electronic and charge transport properties, whereas comparison studies between two-dimensional and three-dimensional core conformations are less reported. To further find useful clues for the design of highly-efficient small molecule HTMs and to find new core units, in this work, four HTM molecules are designed by employing triphenylene, benzotrithiophene, triptycene, and thiophenetriptycene as the core units, and simulated with density functional theory combined with the Marcus hopping model. Our results show that all the considered HTMs display appropriate molecular energy levels, less optical absorption in the visible light region and large Stokes shifts, and high hole mobilities (9.

Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression.

Background: miRNAs play crucial role in the progression of K-Ras-mutated nonsmall cell lung cancer (NSCLC). However, most studies have focused on miRNAs that target K-Ras. Here, we investigated miRNAs regulated by mutant K-Ras and their functions.

FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis.

The external factors that modulate Hippo signaling remain elusive. Here, we report that FGF15 activates Hippo signaling to suppress bile acid metabolism, liver overgrowth, and tumorigenesis. FGF15 is induced by FXR in ileal enterocytes in response to increased amounts of intestinal bile.

One-pot stirring-free synthesis of silver nanowires with tunable lengths and diameters via a Fe & Cl co-mediated polyol method and their application as transparent conductive films.

The properties of nanomaterials are highly dependent on their size, shape and composition. Compared with zero-dimensional nanoparticles, the increased dimension of a one-dimensional silver nanowire (AgNW/Ag NW) leads to extra challenges on synthesizing it with controllable sizes. Here, a convenient way for the synthesis of AgNWs with tunable sizes has been developed simply by adjusting the amount of salt additives, i.

A composite nanostructured electron-transport layer for stable hole-conductor free perovskite solar cells: design and characterization.

A novel composite nanostructured titanium dioxide (TiO2) based electron-transport layer (ETL) is designed by combining size blended nanoparticles (SBNP) and nanoarrays (NA) for efficient perovskite solar cell (PSC) applications. The composite nanostructured (SBNP + NA) ETL is successfully employed in hole-conductor free PSCs, there by achieving a stable device with a maximum efficiency of 13.5%.