Tetrahydroberberrubine improves hyperlipidemia by activating the AMPK/SREBP2/PCSK9/LDL receptor signaling pathway.

Hyperlipidemia is a major risk factor for hypertension, coronary heart disease, diabetes and stroke, triggering an intensified research efforts into its prevention and treatment. Tetrahydroberberrubine (THBru) is a derivative of berberine (BBR) that has been shown to have higher bioavailability and lower toxicity compared to its parent compound. However, its impact on hyperlipidemia has not been fully explored.

Moiré metasurfaces with tunable near-infrared-I chiroptical responses for biomolecular chirality discrimination.

Manipulating circular dichroism in chiral metasurfaces has been increasingly important for a wide range of polarization-sensitive photonic applications. However, simple methods for presenting chiral nanostructures with tunable and considerable chiroptical responses in the near-infrared-I regime remains underexplored. Herein, two sheets of suspended symmetric bilayer metagratings fabricated single-step electron beam lithography are stacked into a moiré metasurface with its circular dichroism value reaching up to 20.

Cascading Water Activation and Interfacial Lattice Oxygen over Nanocluster CuO-Modified MnO for Electrocatalytic Propylene Oxidation.

Direct electrooxidation of propylene using water-oxidation intermediates represents a promising route for propylene glycol production. Unfortunately, this economic and environmentally friendly process suffers from low yield and poor Faradaic efficiency resulting from the mismatched oxidative capacity of reactive oxygen species and pronounced side reactions. Herein, we developed an earth-abundant metal-based nanocluster CuO-modified MnO catalyst for the efficient electrooxidation of propylene into propylene glycol, achieving a remarkable production rate of 63.

Programmable Circular Multispecific Aptamer-Drug Engager to Broadly Boost Antitumor Immunity.

Safely and effectively harnessing innate immunity to boost cancer immunotherapy is promising yet challenging. Hence, we have developed a series of programmable aptamer-based multispecific engagers by encoding various artificial aptamer-drug codons with DNA-templated polymerization, aiming to broadly boost innate and adaptive immunity for antitumor therapy. All circular single-stranded multivalent aptamer-drug conjugates (os-mvApDCs) had a dendritic structure, precise size, and excellent stability, enabling prolonged blood circulation, targeted tumor accumulation, and rapid multireceptor-mediated endocytosis.

The CCL5/CCR5 axis in ulcerative colitis.

Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease characterized mainly by inflammatory changes in the intestinal mucosa. While the specific etiology of UC remains unclear, it is generally believed that it is related to many factors, among which the imbalance in the expression of molecules involved in pro-inflammatory and anti-inflammatory processes can lead to UC. CCL5 (C-C chemokine ligand 5) is one of the key pro-inflammatory factors and plays an indispensable role in various inflammatory diseases, including UC.

Field experimental mode-pairing quantum key distribution with intensity fluctuations.

The mode-pairing quantum key distribution (MP-QKD) protocol, which can achieve high key rates over long distances without phase locking, is a potential candidate for implementing intercity QKD. However, achieving precise control of the light source intensity in a field MP-QKD experiment is an exceedingly challenging task. In this Letter, we study the decoy-state MP-QKD protocol with light source intensity fluctuations.

Damage Characterization of GFRP Hollow Ribbed Emergency Pipes Subjected to Low-Velocity Impact by Experimental and Numerical Analysis.

This paper investigates the low-velocity impact response and damage behavior of glass fiber reinforced polymer (GFRP) hollow ribbed emergency pipes of our design under different impact heights. Drop hammer impact tests with impact velocities of 8.41 m/s, 8.

Estrogen Regulates Ca to Promote Mitochondrial Function Through G-Protein-Coupled Estrogen Receptors During Oocyte Maturation.

Estrogen is a steroid hormone that plays a key role in regulating many physiological processes, such as follicle activation and development and oocyte maturation in mammals. Ca is crucial in oogenesis, oocyte maturation, ovulation, and fertilization. However, the mechanism by which estrogen regulates Ca during oocyte maturation in mice has not been reported.

Direct electrochemical N oxidation to nitrate on supportive Pt/CeO.

Here, we present the development of an efficient Pt/CeO catalyst for electrocatalytic N oxidation to nitrate. Characterization results indicate that highly dispersed Pt and oxygen vacancies from CeO nanocubes (NCs) exhibit strong interactions, which promote the N adsorption on the catalyst surface and suppress the competitive OER activity on oxygen vacancies, resulting in significantly enhanced e-NOR performance.

Obesity is associated with SHBG levels rather than blood lipid profiles in PCOS patients with insulin resistance.

Objective: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by hormonal imbalances and insulin resistance (IR). Among the metabolic abnormalities associated with PCOS, obesity is often present concurrently. Nevertheless, the correlation between obesity, sex hormone levels, and blood lipid profiles in PCOS patients with IR remains uncertain.

Liquid crystal-based polarization-dependent, electrically tunable beam deflectors formed via single-step photopolymerization-induced phase separation.

Compared to mechanical ones, liquid crystal (LC) beam deflectors present several advantages, such as non-mechanical control, compactness, and low power consumption, making them a viable alternative. In this work, we demonstrate an LC-based polarization-dependent, electrically tunable beam deflector, which is a composite blazed grating fabricated using a single-step photopolymerization-induced phase separation (PIPS) technique. We investigated the effect of different factors on the performance of the deflector, including the thickness of the upper substrate, the grating period, and the cell gap.

Real-world effectiveness and safety of azvudine in hospitalized patients with SARS-CoV-2 infection: A multicenter, retrospective cohort study.

Objectives: Azvudine has been designated as a priority treatment for patients infected with SARS-CoV-2, however, clinical evidence in hospitalized cases remains insufficient.

Methods: We performed a multi-center, retrospective cohort study to evaluate the effectiveness and safety of azvudine in hospitalized patients with SARS-CoV-2 in China (NCT06349655). Kaplan-Meier method, Cox regression model, subgroup analysis, and seven sensitive analyses were employed.

High-performance photon-driven DC motor system.

Direct current (DC) motors are crucial in drones, robotics, and electrical devices. Conventionally, the DC motor is driven by a switching electricity converter, which utilizes electrical energy to drive mechanical motion. However, the rapid on-off switching actions in the switching electricity converter would cause electromagnetic interference (EMI), impairing the functionality of drive systems.

Attention-Linear Trajectory Prediction.

Recently, a large number of Transformer-based solutions have emerged for the trajectory prediction task, but there are shortcomings in the effectiveness of Transformers in trajectory prediction. Specifically, while position encoding preserves some of the ordering information, the self-attention mechanism at the core of the Transformer has its alignment invariance that leads to the loss of temporal information, which is crucial for trajectory prediction. For this reason, we design a simple and efficient strategy for temporal information extraction and prediction of trajectory sequences using the self-attention mechanism and linear layers.

Effects of calorie restriction therapy on health-related outcomes in patients with heart failure, a systematic review and meta-analysis.

Aims: We conducted this systematic review to comprehensively assess the impact of CRT on health-related outcomes among patients with HF.

Data Synthesis: In order to find studies investigating the effect of CRT on health-related outcomes among patients with HF, we performed a systematic search of PubMed, Cochrane Library, Embase, and Cumulative Index to Nursing and Allied Health Literature databases (inception until February 12th, 2023). A total of 10 studies including 933 individuals met the inclusion criteria.

A Fast Grasp Planning Algorithm for Humanoid Robot Hands.

Grasp planning is crucial for robots to perform precision grasping tasks, where determining the grasp points significantly impacts the performance of the robotic hand. Currently, the majority of grasp planning methods based on analytic approaches solve the problem by transforming it into a nonlinear constrained planning problem. This method often requires performing convex hull computations, which tend to have high computational complexity.

A case-series study of hepatic left lateral segment inversion for surgical field exposure in laparoscopic gastrectomy.

Purpose: Retraction of the hepatic left lateral segment (HLLS) is a crucial maneuver for surgical field exposure during laparoscopic gastrectomy with systematic lymphadenectomy. Though various methods of retraction are available, there is no perfect solution. Here, we report the results of our initial 42 cases with HLLS inversion method and discuss the feasibility, safety, effectiveness and technical aspects of this method.

Evolution and maintenance of a large multidrug-resistant plasmid in a Typhimurium host under differing antibiotic selection pressures.

The dissemination of antibiotic resistance genes (ARGs) through plasmids is a major mechanism for the development of bacterial antimicrobial resistance. The adaptation and evolution mechanisms of multidrug-resistant (MDR) plasmids with their hosts are not fully understood. Herein, we conducted experimental evolution of a 244 kb MDR plasmid (pJXP9) under various conditions including no antibiotics and mono- or combinational drug treatments of colistin (CS), cefotaxime (CTX), and ciprofloxacin (CIP).

Memristor-based circuit design of BiLSTM network.

The bidirectional long short-term memory (BiLSTM) network involves significant amount of parameter computations. This paper proposes the memristor-based bidirectional long short-term memory (MBiLSTM) network, with its capability of in-memory computing and parallel computing, can accelerates the parameter computations speed. The MBiLSTM network circuit is composed of normalization circuit, two memristor-based long short-term memory (LSTM) circuits, memristor-based resnet circuit, memristor-based dense circuitand winner-take-all (WTA) circuit.

CD94 deficiency or blockade unleashes the anti-tumor immunity in mice and humanized murine models.

NKG2 family members have emerged as promising targets in tumor immunotherapy. CD94 can dimerize with both inhibitory and activating NKG2 proteins, while the overall effect and value of targeting CD94 on anti-tumor immunity are unclear. Here, it is shown that the expression of CD94 is upregulated on tumor-infiltrating natural killer (NK) cells and CD8 T cells, and is related to their exhausted characteristics.