Health care costs among patients with relapsed/refractory multiple myeloma treated with ixazomib or daratumumab in combination with lenalidomide and dexamethasone in the United States.

Background: Available treatments for relapsed/refractory multiple myeloma (RRMM) include multiclass triplet regimens such as lenalidomide and dexamethasone (Rd backbone) plus ixazomib (proteasome inhibitor [PI]; I) or daratumumab (monoclonal antibody; D). Although prior real-world studies compared PI-Rd triplets, this research extends those findings by comparing health care costs of a PI-based and a monoclonal antibody-based triplet, IRd and DRd, in patients with RRMM in the United States.

Objective: To describe and compare all-cause and MM-related health care costs in patients with RRMM treated with IRd vs DRd.

The CCL5/CCR5 axis in ulcerative colitis.

Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease characterized mainly by inflammatory changes in the intestinal mucosa. While the specific etiology of UC remains unclear, it is generally believed that it is related to many factors, among which the imbalance in the expression of molecules involved in pro-inflammatory and anti-inflammatory processes can lead to UC. CCL5 (C-C chemokine ligand 5) is one of the key pro-inflammatory factors and plays an indispensable role in various inflammatory diseases, including UC.

Field experimental mode-pairing quantum key distribution with intensity fluctuations.

The mode-pairing quantum key distribution (MP-QKD) protocol, which can achieve high key rates over long distances without phase locking, is a potential candidate for implementing intercity QKD. However, achieving precise control of the light source intensity in a field MP-QKD experiment is an exceedingly challenging task. In this Letter, we study the decoy-state MP-QKD protocol with light source intensity fluctuations.

Assessment of pharmacokinetics and tolerability following single-dose administration of molnupiravir in participants with hepatic or renal impairment.

Individuals with chronic liver or kidney disease are at increased risk of severe COVID-19. Molnupiravir is an orally administered antiviral authorized for the treatment of mild-to-moderate COVID-19 in adults at risk of progression to severe disease. Two nonrandomized, open-label, single-dose, multicenter, phase 1 trials were conducted to investigate the effects of hepatic and renal impairment on the tolerability and pharmacokinetics of molnupiravir (800 mg) and its metabolite β-D-N4-hydroxycytidine (NHC; NCT05386589/NCT05386758).

Damage Characterization of GFRP Hollow Ribbed Emergency Pipes Subjected to Low-Velocity Impact by Experimental and Numerical Analysis.

This paper investigates the low-velocity impact response and damage behavior of glass fiber reinforced polymer (GFRP) hollow ribbed emergency pipes of our design under different impact heights. Drop hammer impact tests with impact velocities of 8.41 m/s, 8.

Adaptive Forecasting of Nuclear Power Plant Operational Status Under Sensor Concept Drift Using a Bridging Distribution Adaptive Network.

A large number of sensors are required to collect information during the operation of nuclear power plants to ensure their absolutely safe operation. However, because of the unique nature of nuclear reactions, the physical environment of nuclear power production is prone to changes, leading to concept drift in the data collected by the sensors. Concept drift describes the phenomenon of sample distribution changing over time, which typically negatively impacts the model's training and inference processes.

Estrogen Regulates Ca to Promote Mitochondrial Function Through G-Protein-Coupled Estrogen Receptors During Oocyte Maturation.

Estrogen is a steroid hormone that plays a key role in regulating many physiological processes, such as follicle activation and development and oocyte maturation in mammals. Ca is crucial in oogenesis, oocyte maturation, ovulation, and fertilization. However, the mechanism by which estrogen regulates Ca during oocyte maturation in mice has not been reported.

Screening and Selection of a New Medium and Culture Conditions for Diosgenin Production via Microbial Biocatalysis of SYt1.

Diosgenin (DSG) is a phytosterol saponin mainly found in C.H. Wright.

Insights into the hydrogen-fueled bioreduction of vanadium(V) by marine Shewanella sp. FDA-1: Process and mechanism.

Microbial-driven V(V) reduction plays a crucial role in its biogeochemical cycle, yet the mechanisms underlying this bioreduction remain inadequately understood. While the effectiveness of organic compounds as electron donors in facilitating bacterial reduction of V(V) has been established, the role of inorganic electron donors in initiating this process at the level of pure cultured bacteria has not been explored. In this study, we report on a marine Shewanella sp.

The Midline Lateral Parapatellar Arthrotomy: A Safe Alternative Approach for Lateral Tibial Plateau Fractures.

Objectives: The midline lateral parapatellar (LP) approach has been shown in a cadaveric study to provide superior articular exposure compared with the anterolateral approach (AL). The purpose of this study was to report on outcomes and complications with the LP approach.

Design: Retrospective comparative cohort study and prospective cohort.

PM Exposure as a Risk Factor for Optic Nerve Health in Type 2 Diabetes Mellitus.

(1) Objective: This study investigated the relationship between long-term particulate matter (PM) exposure and optic disc parameters-vertical cup-to-disc ratio (vCDR), vertical optic disc diameter (vDD), and vertical optic cup diameter (vCD)-in patients with type 2 diabetes mellitus (T2DM). (2) Methods: A cross-sectional analysis was conducted using data from 65,750 T2DM patients in the 2017-2018 Shanghai Cohort Study of Diabetic Eye Disease (SCODE). Optic disc parameters were extracted from fundus images, and PM exposure was estimated using a random forest model incorporating satellite and meteorological data.

Direct electrochemical N oxidation to nitrate on supportive Pt/CeO.

Here, we present the development of an efficient Pt/CeO catalyst for electrocatalytic N oxidation to nitrate. Characterization results indicate that highly dispersed Pt and oxygen vacancies from CeO nanocubes (NCs) exhibit strong interactions, which promote the N adsorption on the catalyst surface and suppress the competitive OER activity on oxygen vacancies, resulting in significantly enhanced e-NOR performance.

Tailored Enzymes for Difructose Anhydrides: From Biosynthesis to Degradation.

Difructose anhydrides (DFAs), distinctive cyclic disaccharides mainly naturally produced by heating (caramelization), serve as potential candidates of functional sugars that modern humans consume on a daily basis due to their remarkable physiological effects. This review explores the complex domain of specialized enzymes implicated in the metabolism of DFAs, covering the entire process from biosynthesis to degradation. We provide a detailed examination of the enzymes responsible for DFA formation and degradation, specifically those classified within the GH91, GH32, and GH172 glycoside hydrolase families.

Obesity is associated with SHBG levels rather than blood lipid profiles in PCOS patients with insulin resistance.

Objective: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by hormonal imbalances and insulin resistance (IR). Among the metabolic abnormalities associated with PCOS, obesity is often present concurrently. Nevertheless, the correlation between obesity, sex hormone levels, and blood lipid profiles in PCOS patients with IR remains uncertain.

Mitochondrial DNA (mtDNA) accelerates oxygen-glucose deprivation-induced injury of proximal tubule epithelia cell via inhibiting NLRC5.

The high morbidity and mortality associated with acute kidney injury (AKI) are global health concerns. AKI is commonly attributed to ischemia/reperfusion injury (IRI), a condition characterized by activation of inflammatory responses and mitochondrial dysfunction. Nonetheless, mitochondrial DNA (mtDNA) has the potential to induce renal IRI.

Discovery of potential female-specific biomarkers for major depressive disorder by LC-MS-based metabolomics.

The prevalence of major depressive disorder (MDD) is higher in females than males, emphasizing the need to identify gender-specific biomarkers to improve diagnosis accuracy. In this study, a cross-sectional investigation with 258 samples was conducted to evaluate the discriminative power of potential gender-specific biomarkers for MDD. Eighteen MDD-related differential metabolites have been identified, involving pathways of phospholipids, glycerolipids, fatty acids, sphingolipids, cholesterol, vitamin E, and heme.

The Relationship Between Interparental Conflict and Social Anxiety Among Chinese College Students: A Moderated Mediation Model.

Purpose: Our aim is to construct a moderated mediation model for investigating the effect of interparental conflict on social anxiety, the potential mediating role of psychological resilience, the moderating effect of perceived social support on this association, and the gender difference among Chinese college students.

Methods: This cross-sectional survey was conducted on 1343 Chinese college students from Anhui Province, Hunan Province, Jiangsu Province, and Henan Province, China, in March 2024. Pearson correlation, mediation effects analyses, and multiple-group comparison were conducted.

Comparative characterization of key compounds of Sauce-flavored rounded-Baijiu in northern and southern China and the potential possibility of similar quality of their combined products.

The flavor characteristics and sensory attributes of northern Sauce-flavored rounded-Baijiu (NR) and southern Sauce-flavored rounded-Baijiu (SR) were systematically studied. A total of 56 major flavor compounds were quantitatively detected through Gas chromatography-flame ionization detection (GC-FID). Besides, 20 kinds of key aroma compounds and 7 significant differential compounds were identified by calculating the odor activity values (OAVs) and orthogonal partial least squares discriminant analysis (OPLS-DA) of flavor compounds in NR and SR.

Community versus academic hospital community-acquired pneumonia patients: a nested cohort study.

Background: Most Canadians receive their care in community hospitals, yet most clinical research is conducted in academic hospitals. This study aims to compare patients with community acquired pneumonia (CAP) treated in academic and community hospitals with respect to their demographics, clinical characteristics, treatments and outcomes.

Methods: This nested observational cohort substudy of the Community Acquired Pneumonia: Toward InnoVAtive Treatment (CAPTIVATE) trial included 1,329 hospitalized adults with CAP recruited between March 1st, 2018 and September 31st, 2023 from 15 Canadian hospitals.

Medical Student Mentorship Program in Diagnostic Radiology: The Value of Resident-Led Radiology Mentoring in Early Medical Education.

Mentorship is an often insufficiently acknowledged yet powerful tool to recruit medical students to various specialties and provide guidance as they advance through the stages of their medical career. While the number of specialty-specific mentorship programs available to medical students across the country is on the rise, the utility of trainee-led mentorship is yet to be explored. The purpose of this study is to share a single-institution's experience with implementing a trainee-led radiology mentorship program.

Monoamine transporter ubiquitination and inward-open conformation synergistically maximize transporter endocytosis.

Monoamine transporters function in neuronal membranes to control extracellular concentrations of their substrates. Cell-surface expression of transporters is regulated by substrates and intracellular signaling, but the underlying mechanisms remain unclear. Here, we found that substrates of the dopamine transporter (DAT), amphetamine and dopamine, synergize with protein kinase C (PKC)-dependent DAT ubiquitination to markedly elevate clathrin-mediated endocytosis of DAT, which is accompanied by DAT movement out of plasma membrane protrusions with a negative curvature.

Cytological mapping of a powdery mildew resistance locus PmRc1 based on wheat-Roegneria ciliaris structural rearrangement library.

A powdery mildew (Pm) resistance locus PmRc1 was identified and transferred from Roegneria ciliaris into wheat. Two compensative translocation lines carrying PmRc1 were developed. Powdery mildew (Pm), caused by the biotrophic fungal pathogen Blumeria graminis f.

Projections of the Stroke Burden at the Global, Regional, and National Levels up to 2050 Based on the Global Burden of Disease Study 2021.

Background: Stroke is a pressing public health issue worldwide. This study aimed to forecast the future temporal trends and distribution characteristics of the global stroke burden.

Methods And Results: Global data on stroke incidence, prevalence, deaths, and disability-adjusted life years between 1990 and 2021 were obtained from the GBD (Global Burden of Disease) Study 2021.