Angiographic Observation of the Perforators of Thoracodorsal Artery and Application of the Perforator Flaps in Repairing Adjacent Wounds.

Objective: The thoracodorsal artery perforator flap has not been widely used in clinical practice partly due to a lack of imaging evidence. The authors aim to investigate the types of thoracic dorsal artery perforators through angiography and provide our experiences in the utilization of thoracic dorsal artery perforator flaps to repair adjacent wounds.

Methods: This study was divided into two parts.

Iron-containing nanominerals for sustainable phosphate management: A comprehensive review and future perspectives.

Adsorption, which is a quick and effective method for phosphate management, can effectively address the crisis of phosphorus mineral resources and control eutrophication. Phosphate management systems typically use iron-containing nanominerals (ICNs) with large surface areas and high activity, as well as modified ICNs (mICNs). This paper comprehensively reviews phosphate management by ICNs and mICNs in different water environments.

Identification of tumor antigens and immune subtypes of hepatocellular carcinoma for mRNA vaccine development.

Background: mRNA vaccines have been investigated in multiple tumors, but limited studies have been conducted on their use for hepatocellular carcinoma (HCC).

Aim: To identify candidate mRNA vaccine antigens for HCC and suitable subpopulations for mRNA vaccination.

Methods: Gene expression profiles and clinical information of HCC datasets were obtained from International Cancer Genome Consortium and The Cancer Genome Atlas.

Device-independent quantum randomness-enhanced zero-knowledge proof.

Zero-knowledge proof (ZKP) is a fundamental cryptographic primitive that allows a prover to convince a verifier of the validity of a statement without leaking any further information. As an efficient variant of ZKP, noninteractive zero-knowledge proof (NIZKP) adopting the Fiat-Shamir heuristic is essential to a wide spectrum of applications, such as federated learning, blockchain, and social networks. However, the heuristic is typically built upon the random oracle model that makes ideal assumptions about hash functions, which does not hold in reality and thus undermines the security of the protocol.

[Effect of electroacupuncture pretreatment on PPARγ-mediated pyroptosis of cerebral cortex in rats with cerebral ischemia reperfusion injury].

Objective: To observe the effect of (promoting the circulation of the governor vessel and regulating the spirit) electroacupuncture (EA) pretreatment on pyroptosis mediated by peroxisome proliferators-activated receptor γ (PPARγ) of the cerebral cortex in rats with cerebral ischemia reperfusion injury (CIRI) and explore the potential mechanism of EA for the prevention and treatment of CIRI.

Methods: A total of 110 clean-grade male SD rats were randomly divided into a sham-operation group, a model group, an EA group, an EA + inhibitor group and an agonist group, 22 rats in each group. In the EA group, before modeling, EA was applied to "Baihui" (GV 20), "Fengfu" (GV 16) and "Dazhui" (GV 14), with disperse-dense wave, 2 Hz/5 Hz in frequency, 1 to 2 mA in intensity, lasting 20 min; once a day, consecutively for 7 days.

Net ecosystem productivity of Panjin wetland during 1971 to 2020 and its impact factors.

Coastal estuarine wetland ecosystem has strong ability for carbon (C) storage and sequestration. Accurate assessment of C sequestration and its environmental impact factors is the basis of scientific protection and mana-gement of coastal estuarine wetlands. Taking the Panjin reed () wetland as the object, we used terrestrial ecosystem model, together with Mann-Kendall mutation test, statistical analysis methods, and scenario simulation experiment, to analyze the temporal characteristics, stability, changing trend of net ecosystem production (NEP) of wetlands and the contribution rate of environmental impact factors to NEP during 1971 to 2020.

[Professor 's clinical experience of acupuncture and moxibustion with for adolescent depressive disorder].

Professor 's clinical experience of acupuncture and moxibustion with (promoting and regaining consciousness) for adolescent depressive disorder is introduced. It is believed that the internal causes of adolescent depressive disorder are mostly emotional and physical factors, while the external causes are mainly social factors, and stagnation and emotional disorder are the key pathogenesis. The key of acupuncture and moxibustion with is warming and regulating the governor vessel.

Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria.

Only a small proportion of patients with triple-negative breast cancer benefit from immune checkpoint inhibitor (ICI) targeting PD-1/PD-L1 signaling in combination with chemotherapy. Here, we discovered that therapeutic response to ICI plus paclitaxel was associated with subcellular redistribution of PD-L1. In our immunotherapy cohort of ICI in combination with nab-paclitaxel, tumor samples from responders showed significant distribution of PD-L1 at mitochondria, while non-responders showed increased accumulation of PD-L1 on tumor cell membrane instead of mitochondria.

The mechanisms and roles of melatonin in gastrointestinal cancer.

Gastrointestinal (GI) cancer is a global health problem with wide lesions and numerous cases. The increased morbidity and mortality of GI cancer is a socio-economic challenge for decades to come. Melatonin, a nature indolamine, exerts a crucial role in molecular interactions involved in multiple functional and physiological processes.

[Acupuncture combined with decoction for stroke-associated pneumonia with phlegm-heat obstructing lung and its effect on cellular immune function].

Objective: To observe the clinical effect of acupuncture combined with decoction for stroke-associated pneumonia (SAP) with phlegm-heat obstructing lung, and explore its possible mechanism.

Methods: Ninety-nine patients of SAP with phlegm-heat obstructing lung were randomly divided into a combination group (33 cases, 1 case dropped off), a Chinese medication group (33 cases, 1 case dropped off) and an acupuncture group (33 cases, 1 case dropped off). On the basis of routine basic treatment, the patients in the acupuncture group were treated with acupuncture at Tiantu (CV 22), Feishu (BL 13), Taiyuan (LU 9), Sanyinjiao (SP 6), etc.

Effects of warming, eutrophication and climate variability on acidification of the seasonally stratified North Yellow Sea over the past 40 years.

The North Yellow Sea (NYS) is a productive marginal sea of the western North Pacific. In summer and autumn, CaCO saturation states beneath the seasonal thermocline in the NYS have frequently fallen below critical levels, indicating that marine calcifying organisms are under threat. To explore the long-term evolution of the acidification of the NYS, we reconstructed seasonal variations in subsurface aragonite saturation state (Ω) and pH during 1976-2017, using wintertime and summertime temperature, salinity, dissolved oxygen and pH data mainly from a quality-controlled oceanographic database.

Association between coronary artery calcification and cognitive function in a Chinese community-based population.

Background: Coronary atherosclerosis and cognitive impairment are both age-related diseases, with similar risk factors. Coronary artery calcium (CAC), a marker of coronary atherosclerosis, may play a role in early detection of individuals prone to cognitive decline. This study aimed to investigate the relationship between CAC and cognitive function, and the capability of CAC to identify participants with a high risk of dementia in a Chinese community-based population.

Outside-in catalytic graphitization method for synthesis of dispersible and uniform graphitic porous carbon nanospheres.

Common strategies to synthesize graphitic porous carbon nanospheres suffer from energy consumption, exorbitant cost and harsh condition, and lead to closed pore and polydisperse particles. The successful manipulation of adjustable graphitic skeleton, developed porosity, good monodispersity and dispersity of carbon nanospheres is essential to meet their structural varieties and practical applications. Herein, an outside-in catalytic graphitization method is reported to synthesize carbon nanospheres with abovementioned properties, which involves interfacial assembly between layered double hydroxides nanosheets and polymer nanospheres, in-situ generation of nickel nanoparticles, and outside-in catalytic graphitization.

Bioaccumulation of perfluoroalkyl substances in greenhouse vegetables with long-term groundwater irrigation near fluorochemical plants in Fuxin, China.

The levels of perfluoroalkyl substances (PFASs) have been growing progressively in the groundwater beneath a fluorochemical industrial park (FIP) in Fuxin of China recently, however, little information is available about whether long-term irrigation with local groundwater could have a potential effect on the bioaccumulation of PFASs in greenhouse vegetables near the FIP. In the present study, groundwater, soil, and vegetable samples were collected from Fuxin with five sampling campaigns during a period of 40 days, and ten target analytes of PFASs in all the samples were analyzed via high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). As the dominant PFAS contaminants, perfluorooctanoic acid (PFOA) and perfluorobutane sulfonate (PFBS) in groundwater samples were determined with the maximum levels of 2.