Population dynamics and the role of protected areas in China's milu deer (Elaphurus davidianus) rewilding.

Protected areas are refugia for wildlife and play a crucial role in biodiversity conservation, especially in the restoration of rare and endangered species. However, little attention has been paid to the long-term contribution of protected areas to rare species population rejuvenation. To identify the population growth of milu deer (Elaphurus davidianus)in protected areas and unprotected areas, we fitted the population dynamics curve of reintroduced free-ranging and wild populations based on long-term monitoring data in four protected areas: Jiangsu Dafeng Milu National Nature Reserve, Hubei Shishou Milu National Nature Reserve, Hunan East Dongting Lake National Nature Reserve, and Jiangxi Poyang Lake area.

CD300E macrophages facilitate liver regeneration after splenectomy in decompensated cirrhotic patients.

Liver cirrhosis is prognostically associated with poor life expectancy owing to subsequent liver failure. Thus, understanding liver regeneration processes during cirrhotic injury is highly important. This study explored the role of macrophage heterogeneity in liver regeneration following splenectomy.

Development of a peptide-based tumor-activated checkpoint inhibitor for cancer immunotherapy.

Antibody-based checkpoint inhibitors have achieved great success in cancer immunotherapy, but their uncontrollable immune-related adverse events remain a major challenge. In this study, we developed a tumor-activated nanoparticle that is specifically active in tumors but not in normal tissues. We discovered a short anti-PD-L1 peptide that blocks the PD-1/PD-L1 interaction.

Exploring Multivalency in the Development of Anti-PD-L1 Peptides for Cancer Immunotherapy.

Purpose: The PD-1/PD-L1 pathway is one of the most effective immune checkpoint pathways utilized for cancer immunotherapy. Despite the success of anti-PD-1/PD-L1 mAbs, there is growing interest in developing low molecular weight anti-PD-1/PD-1 agents, such as peptides, because of their improved tumor penetration. We recently developed a small anti-PD-L1 peptide and demonstrated its promising anti-tumor activity.

Case report: Unveiling the silent threat in the ICU - a case of disseminated invasive aspergillosis in a patient with fulminant myocarditis.

Invasive aspergillosis (IA) significantly increases mortality in critically ill patients in the ICU and its occurrence is closely related to immunocompromise. Dissemination of IA is easily misdiagnosed and mistreated due to its ability to invade multiple systems throughout the body and lack of typical clinical manifestations. In this case, a 25-year-old previously healthy woman was hospitalized with fulminant myocarditis and treated with veno-arterial extracorporeal membrane pulmonary oxygenation (VA-ECMO) support and intravenous acyclovir, high-dose methylprednisolone, and immunoglobulin.

Directional anchoring of polymer-lysozyme nanohybrids for adhesive capture and enhanced removal of Alicyclobacillus acidoterrestris in fruit juices.

The acidophilic and heat-resistant traits of Alicyclobacillus acidoterrestris (A. acidoterrestris) present a formidable challenge to fruit juices production safety. To address the limitations of conventional thermal sterilization, a novel bacterial capture device MPDEL has been developed.

Age-Related Differences in the Association between Life's Essential 8 and Cognition in Cognitively Normal Adults: The CABLE Study.

Background: This study investigated the relationship between Life's Essential 8 (LE8), a recently updated lifestyle-related health factor, and cognition across multiple life stages.

Methods: We enrolled 1098 cognitively normal participants from the Chinese Alzheimer's Biomarker and Lifestyle (CABLE) study. We investigated the interactions between age and LE8 on cognition.

identification and verification of Tanshinone IIA-related prognostic genes in hepatocellular carcinoma.

Background: Currently, adequate treatment and prognostic prediction means for Hepatocellular Carcinoma (HCC) haven't entered into medical vision. Tanshinone IIA (TanIIA) is a natural product, which can be utilized as a potential treatment of HCC due to its high anti-tumor activity. However, the effect on HCC prognosis, as well as the potential targets and molecular mechanism of TanIIA still remain ambiguous.

Boost Electrocatalytic Activity of LaSrCoFeO Air Electrode Prepared by High-Temperature Shock for Solid Oxide Electrochemical Cells.

High-temperature shock (HTS) is an emerging material synthesis technology with advantages, such as rapid processing, low energy consumption, and high controllability. This technology can prepare ultrafine nanoparticles with uniform particle size distribution and introduce additional oxygen vacancies, offering significant potential for the preparation of key materials for solid oxide electrochemical cells (SOCs). In this study, the LaSrCoFeO (LSCF) air electrode was successfully prepared using HTS technology.

Influence of preoperative HbA1c levels on the occurrence of postoperative complications in patients undergoing coronary artery bypass grafting.

Objective: To explore the impact of preoperative HbA1c levels on postoperative complications in coronary heart disease patients undergoing coronary artery bypass grafting (CABG).

Methods: From September 2020 to November 2022, 98 patients with coronary heart disease who were preparing to receive CABG treatment in a cardiac surgery department of a certain hospital were included in the study using the retrospective analysis. According to the preoperative serum hemoglobin A1C (HbA1c) test results, patients were divided into a low-level group (HbA1c < 5.

Experimental study on high temperature gaseous hydrogen fluoride corrosion of boiler water-cooled wall pipes.

Hydrogen fluoride (HF) corrosion of boiler water-cooled wall pipes at high temperature hinders the co-disposal of fluorinated hazardous wastes and coal by combustion. In this paper, common water-cooled wall pipes (15CrMoG and 20G) were utilized to perform gaseous HF corrosion experiments at high temperature on a horizontal tube furnace. The effects of temperature on HF corrosion of different water-cooled wall pipes in 0.

Delivery of a STING Agonist Using Lipid Nanoparticles Inhibits Pancreatic Cancer Growth.

Introduction: The tumor microenvironment (TME) of pancreatic cancer is highly immunosuppressive and characterized by a large number of cancer-associated fibroblasts, myeloid-derived suppressor cells, and regulatory T cells. Stimulator of interferon genes (STING) is an endoplasmic reticulum receptor that plays a critical role in immunity. STING agonists have demonstrated the ability to inflame the TME, reduce tumor burden, and confer anti-tumor activity in mouse models.

Deep learning approach for unified recognition of driver speed and lateral intentions using naturalistic driving data.

Driver intention recognition is a critical component of advanced driver assistance systems, with significant implications for improving vehicle safety, intelligence, and fuel economy. However, previous research on driver intention recognition has not fully considered the influence of the driving environment on speed intentions and has not exploited the temporal dependency inherent in the lateral intentions to prevent erroneous changes in recognition. Furthermore, the coupling of speed and lateral intentions was overlooked; they were generally considered separately.

The Co-pathogenic Target Gene CNTN1 Involved in Coronary Artery Disease and Pulmonary Arterial Hypertension Has Potential for Diagnosis of Coronary Artery Disease.

We aimed to find a gene for coronary artery disease (CAD) early diagnosis by detecting co-pathogenic target gene involved in CAD and pulmonary arterial hypertension (PAH). Methods: Datasets were obtained from the Gene Expression Omnibus (GEO) database, including GSE113079, GSE113439, and GSE12288, to investigate gene expression patterns in cardiovascular diseases. Weighted Gene Co-expression Network Analysis (WGCNA) was performed to identify gene modules associated with clinical traits.

Geriatric nutrition risk index in the prediction of all-cause and cardiovascular mortality in older adults with hyperlipidemia: NHANES 1999-2018.

Background: Malnutrition is linked to a higher risk of unfavorable outcomes in various illnesses. The present investigation explored the correlation between inadequate nutritional condition and outcomes in older individuals diagnosed with hyperlipidemia.

Methods: The geriatric nutritional risk index (GNRI) was used to evaluate the nutritional status.

Applications of Biosensors in Bladder Cancer.

Bladder cancer (BC) is the tenth most common cancer globally, predominantly affecting men. Early detection and treatment are crucial due to high recurrence rates and poor prognosis for advanced stages. Traditional diagnostic methods like cystoscopy and imaging have limitations, leading to the exploration of noninvasive methods such as liquid biopsy.

Assessing perceptions of stigmatization by others for seeking help in China: psychometric characteristics and measurement invariance across gender and therapy experience.

The stigma of social networks may be more noticeable in collectivist societies like China, but research in this area has largely been overlooked due to a lack of reliable measurement. To address this gap, this study tested the psychometric properties of the Chinese version of the Perceptions of Stigmatization by Others for Seeking Help (PSOSH) scale in the Chinese general population, and tested its invariance across gender and prior therapy experience. In a national online survey, 640 adults completed the PSOSH and conceptually related scales: Self-stigma of Seeking Help (SSOSH), Stigma of Seeking Professional Psychological Help Scale (SSPPH, i.

Biochar boosted high oleic peanut production with enhanced root development and biological N fixation by diazotrophs in a sand-loamy Primisol.

Peanut yield and quality face significant threats due to climate change and soil degradation. The potential of biochar technology to address this challenge remains unanswered, though biochar is acknowledged for its capacity to enhance the soil microbial community and plant nitrogen (N) supply. A field study was conducted in 2021 on oil peanuts grown in a sand-loamy Primisol that received organic amendments at 20 Mg ha.

Nuclear matrix protein 22 in bladder cancer.

Bladder cancer (BC) is ranked as the ninth most common malignancy worldwide, with approximately 570,000 new cases reported annually and over 200,000 deaths. Cystoscopy remains the gold standard for the diagnosis of BC, however, its invasiveness, cost, and discomfort have driven the demand for the development of non-invasive, cost-effective alternatives. Nuclear matrix protein 22 (NMP22) is a promising non-invasive diagnostic tool, having received FDA approval.

Factors affecting the intention to wear helmets for e-bike riders: the case of Chinese college students.

As the popularity of electric bicycles (e-bikes) continues to surge, the number of accidents involving them has commensurately increased. A significant factor contributing to the high fatality rate in these accidents is the low usage of helmets among e-bike riders. Helmets have been proven to reduce the severity of injuries, yet their usage remains unexpectedly low.