Clinical characteristics and treatment of pyrrolizidine alkaloid-related hepatic vein occlusive disease.

Background And Aims: Hematopoietic stem cell transplantation related hepatic vein occlusive disease (HSCT-HVOD) has been researched extensively; however, little is known about the clinical features and treatment of pyrrolizidine alkaloid-induced HVOD (PA-HVOD). This retrospective single centre study examined the clinical and laboratory characteristics of 108 patients with acute PA-HVOD and explored the efficacy of anticoagulation and TIPS therapy.

Methods: The study included 108 consecutive patients with PA-HVOD between July 2008 and June 2016.