Publications by authors named "Cheng Hyun Lee"
Muscle-invasive urothelial carcinoma (MIUC) of the bladder shows highly aggressive tumor behavior, which has prompted the quest for robust biomarkers predicting invasion. To discover such biomarkers, we first employed high-throughput proteomic method and analyzed tissue biopsy cohorts from patients with bladder urothelial carcinoma (BUC), stratifying them according to their pT stage. Candidate biomarkers were selected through bioinformatic analysis, followed by validation.
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- Metabolic dysregulation plays a key role in cancer, and Nicotinamide (NAM), a form of vitamin B3, is explored for its potential therapeutic effects in triple-negative breast cancer (TNBC).
- The study found that NAM alters mitochondrial function by decreasing membrane potential and ATP production while enhancing certain metabolic pathways, ultimately increasing reactive oxygen species (ROS).
- Elevated ROS levels lead to cancer cell apoptosis and hinder tumor growth and metastasis, suggesting that NAM could be repurposed as a promising anti-metabolic agent for treating TNBC.
Purpose: A relatively low response to chemotherapy has been reported for hormone receptor (HR)-positive breast cancer. In this study, we investigated the role of tryptophanyl-transfer RNA synthetase WARS) in the chemotherapeutic response of HR-positive breast cancer.
Methods: Pre-chemotherapeutic needle biopsy samples of 45 HR-positive breast cancer patients undergoing the same chemotherapeutic regimen were subjected to immunohistochemistry.