Publications by authors named "Cheng Hsien Hung"
New Insights into the Role of SGLT-2 Inhibitors in the Prevention of Dementia.
Neurol Int
December 2024
Diabetes mellitus (DM) is a chronic disease associated with numerous complications, including cardiovascular diseases, nephropathy, and neuropathy. Sodium-glucose cotransporter 2 (SGLT-2) inhibitors, a class of novel antidiabetic agents, have demonstrated promising therapeutic effects beyond glycemic control, with potential benefits extending to the cardiovascular and renal systems. Recently, research has increasingly focused on exploring the potential role of SGLT-2 inhibitors in preventing dementia.
View Article and Find Full Text PDFGabapentinoids for chemotherapy-induced peripheral neuropathy: systematic review and meta-analysis.
BMJ Support Palliat Care
August 2024
Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) affects patients' quality of life and treatment effectiveness. Gabapentinoids, like gabapentin and pregabalin, are often used for CIPN treatment, but their efficacy and safety remain uncertain. This study reviews and analyses randomised controlled trial data on this topic.
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- Early neurological deterioration (END) within 72 hours of a stroke is linked to worse patient outcomes, and this study explored whether better hydration can help mitigate that risk.
- The research involved 488 ischemic stroke patients who were randomly assigned to receive either enhanced hydration or standard hydration, assessing outcomes like major and minor END at 72 hours post-admission.
- Ultimately, the study found no significant difference in the rates of major END or early neurological improvement between the two hydration methods, indicating that enhanced hydration does not improve short-term results for stroke patients.
Within 6 months of the coronavirus pandemic, a new disease entity associated with a multisystem hyperinflammation syndrome as a result of a previous infection with the SARS-CoV-2 virus is increasingly being identified in children termed Multisystem Inflammatory Syndrome in Children (MIS-C) and more recently in adults(MIS-A). Due to its clinical similarity with Kawasaki Disease, some institutions have used intravenous immunoglobulins and steroids as first line agents in the management of the disease. We seek to find how effective intravenous immunoglobulin therapy is across these two disease entities.
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- Radiation dermatitis is a common issue in breast cancer patients undergoing radiation therapy, potentially impacting their treatment and outcomes.
- A study analyzed 45 research papers, narrowing it down to 19 studies involving 2,288 patients, but found that no topical prevention strategies were more effective than standard care.
- The conclusion suggests that current options for preventing severe radiation dermatitis are equally effective, highlighting the need for further research to find better solutions.
Capecitabine-induced hand-foot syndrome (HFS) is common in clinical practice. There are many regimens used to prevent HFS. However, the most effective preventive regimen has not yet been identified.
View Article and Find Full Text PDFBackground/aim: Head and neck cancer is a major malignancy worldwide. The treatment strategy for head and neck cancer usually involves radiotherapy. The main side effect of radiotherapy is radiation dermatitis.
View Article and Find Full Text PDFLetter: COVID-19 outcomes and anti-TNF treatments-comprehensive evidence matters.
Aliment Pharmacol Ther
May 2022
This article is linked to Kokkotis et al papers. To view these articles, visit https://doi.org/10.
View Article and Find Full Text PDFSepsis is a life-threatening condition, and serum lactate levels have been used to predict patient prognosis. Studies on serum lactate levels in patients undergoing regular hemodialysis who have sepsis are limited. This study aimed to determine the predictive value of serum lactate levels for sepsis-related mortality among patients who underwent last hemodialysis at three different times before admission to the emergency department (ED).
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- ESBL-positive bloodstream infections are increasing globally, and this study aims to assess how inappropriate initial antibiotic therapy (IIAT) affects in-hospital mortality in these patients.
- The study analyzed data from 3533 adult patients with bloodstream infections over a span of six years, revealing a 16% in-hospital mortality rate, with ESBL-positive cases showing the highest mortality.
- Findings indicated that a high qSOFA score (≥2) was the strongest predictor of mortality, while IIAT and the timing of antibiotic treatment did not significantly impact outcomes once disease severity was taken into account.
Liver cirrhosis affects serum lactate level measurement while assessing disease severity in patients with sepsis.
Eur J Gastroenterol Hepatol
September 2021
Background: Elevated serum lactate is associated with higher mortality in sepsis, whereas liver dysfunction is associated with higher serum lactate levels. We assessed the predictive ability of serum lactate in patients with liver cirrhosis and sepsis.
Methods: This retrospective study included 12 281 cases of suspected infection with initial serum blood lactate drawn during January 2007-December 2013.
Objective: This study assessed the effect of prior statin use on the 28-day mortality of patients with type 2 diabetes mellitus (DM) who develop bloodstream infections.
Methods: This retrospective cohort study included all adult type 2 DM patients with bacteremia and verified prior medication history who visited the emergency department of a single tertiary hospital between January 2007 and December 2013. All major adverse consequences including septic shock events, use of mechanical ventilation, intensive care unit admission, and 28-day mortality were assessed.
Article Synopsis
- The study investigates how metformin impacts lactate levels and their effectiveness in predicting 28-day mortality for patients with sepsis and bacteremia.
- Metformin users had higher mean serum lactate levels compared to nonusers, particularly in those with severe sepsis (qSOFA score ≥2).
- The optimal lactate cut-off for predicting mortality was 5.9 mmol/L for metformin users, indicating a need for higher lactate levels to enhance predictive accuracy in these patients.
Background: Several comorbidities contribute to an increased risk of infections in Parkinson's disease (PD) as the disease progresses. However, few studies have examined the correlation between sepsis and PD.
Aim: The aim of this study is to disclose the presentation and outcome of serious infection in patients with PD in the emergency department.