Publications by authors named "Cheng Hong Yap"
Staphylococcus aureus is a highly adaptable opportunistic pathogen that can form biofilms and generate persister cells, leading to life-threatening infections that are difficult to treat with antibiotics alone. Therefore, there is a need for an effective S. aureus biofilm inhibitor to combat this public health threat.
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- - Staphylococcal surgical site infections are common in hospitals, prompting the need for better infection prevention methods, such as using antiseptic-coated sutures; however, concerns over antibiotic resistance have led to seeking alternative antimicrobial solutions.
- - This study investigated menadione (Vitamin K) as a potential antimicrobial coating for sutures and found it effectively inhibits staphylococcal biofilm growth, particularly against both methicillin-susceptible and resistant strains.
- - Menadione-coated sutures demonstrated significant antimicrobial activity without compromising their integrity or strength, suggesting it could be a promising option for reducing surgical site infections in light of rising antibiotic resistance.