A multimedia patient simulation for teaching and assessing endodontic diagnosis.

Teaching and assessing diagnostic skills are difficult due to relatively small numbers of total clinical experiences and a shortage of clinical faculty. Patient simulations could help teach and assess diagnosis by displaying a well-defined diagnostic task, then providing informative feedback and opportunities for repetition and correction of errors. This report describes the development and initial evaluation of SimEndo I, a multimedia patient simulation program that could be used for teaching or assessing endodontic diagnosis.

Three-dimensional analysis of dual-arch impression trays.

Objective: The objective of this investigation was to measure and compare the dimensions of casts made using four types of impression trays and two impression materials to the dimensions of the original master model. This study differed from previous studies by using three-dimensional measurement.

Method And Materials: Vinyl polysiloxane and polyether impressions were made of two crown preparations of ivorine teeth cemented into an acrylic master model.

The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2.

Modification of the pyrimidone 5-substituent in clinical candidate SB-435495 has given a series of inhibitors of recombinant lipoprotein-associated phospholipase A(2) with sub-nanomolar potency. Cyclopentyl fused derivative 21, SB-480848, showed an enhanced in vitro and in vivo profile versus SB-435495 and has been selected for progression to man.