A novel rabies vaccine based on infectious propagating particles derived from hybrid VEEV-Rabies replicon.

Background: Live attenuated vaccines (LAVs) can mimic natural infection and have advantages to stimulate a robust and sustained immune response as well as to confer long-term protection. However, safety concerns is one of the major obstacles for LAVs development. In an effort to achieve the optimal balance between immunogenicity and safety, researchers currently have taken different strategies for the development of LAVs.

PALB2 mutations in breast cancer patients from a multi-ethnic region in northwest China.

Background: Germline mutations in PALB2 gene make a small contribution to heritable breast cancer susceptibility. A recent report has revealed that women with mutations in the PALB2 gene were more than nine times as likely to develop breast cancer compared to those without. The aim of this study is to understand the status of PALB2 mutations among Chinese high-risk breast cancer patients in a multi-ethnic region in China.

[Comparison of ultrasound-guided transrectal and transperineal prostate biopsies in clinical application].

Objective: To compare the positive rates and complications of ultrasound-guided transrectal and transperineal prostate biopsies.

Methods: We retrospectively analyzed 156 cases of ultrasound-guided transrectal (n = 97) and transperineal (n = 59) prostate biopsy, and compared the positive rate and post-biopsy complications between the two approaches.

Results: The positive rates in the transrectal and transperineal groups were 48.