Hesperidin inhibits colon cancer progression by downregulating SLC5A1 to suppress EGFR phosphorylation.

Hesperidin, an active constituent of traditional Chinese medicine, Chenpi, exhibits anticancer properties across different cancers. This study aimed to clarify the efficacy of Hesperidin against tumors and its mechanisms of action in colon cancer. : We assessed the efficacy of Hesperidin on human colon cancer cells (HCT-116 and DLD-1) and normal colonic epithelial cells (NCM460).

A novel efficient liquefaction process for corn starch through ternary deep eutectic solvent: Products characterization and liquefaction mechanism.

A novel approach for the solvothermal liquefaction of corn starch (CS) was investigated, using ternary deep eutectic solvent (TDES) as both an acidic catalyst and a source of liquefaction reagent. Synergistic effects from multi-component TDES were observed, leading to milder reaction conditions (110 °C, 35 min) and improved product selectivity (relative content of polyhydroxy compounds up to 97.83 %).

Association between dietary carotenoids intake and fecal incontinence in American adults: evidence from NAHNES 2005-2010.

Object: Carotenoids represent a class of bioactive compounds with potential implications for gut health. However, the relationship between dietary carotenoid intake (DCI) and fecal incontinence (FI) remains unclear. This study aims to elucidate the association between DCI and the risk of FI.

Multi-habitat utilization and diverse life history of the endangered Sea Carp (Cyprinus acutidorsalis) in the Wanquan Estuary, Hainan island, China: Evidence from otolith microchemistry.

The Sea Carp Cyprinus acutidorsalis (Wang) is an endemic species limited to a few estuaries in China, uniquely adapted to long-term residence in brackish water environments. This species is endangered due to anthropogenic disturbances, and its life history and habitat use remain poorly understood. This study is the first to investigate the life history and habitat utilization of Sea Carp in the Wanquan Estuary, Hainan Province, China, using otolith microchemistry.

Evidence from In Situ Bioassays and Suspect Analysis Revealed the Region-Specific Aquatic Risk across Socioeconomic Gradients in China.

Various contaminants are present in aquatic environment and pose potential threats to pelagic and benthic organisms, calling for effective risk assessment. Traditional risk assessments based on target analysis are useful when the principal contaminants responsible for ecological risk are known; however, these approaches become challenging when dealing with chemical mixtures. In addition, the compositions of chemical mixtures often differ in regions with different levels of socioeconomic development, requiring risk assessment methods that are applicable under different pollution scenarios.

Common laboratory results-based artificial intelligence analysis achieves accurate classification of plasma cell dyscrasias.

Background: Plasma cell dyscrasias encompass a diverse set of disorders, where early and precise diagnosis is essential for optimizing patient outcomes. Despite advancements, current diagnostic methodologies remain underutilized in applying artificial intelligence (AI) to routine laboratory data. This study seeks to construct an AI-driven model leveraging standard laboratory parameters to enhance diagnostic accuracy and classification efficiency in plasma cell dyscrasias.

fusion gene in hematological neoplasms: clinical features, current practices, and prognoses.

Introduction: -, formerly , is a rarely reported fusion gene in hematological malignancies, especially in Asian people.

Case Presentations: Six patients with fusion gene were identified at the First Affiliated Hospital, Zhejiang University School of Medicine, China between October 2019 and October 2023, with a median age of 25 years. Clinical diagnoses included acute myeloid leukemia (AML) in 2 patients, acute lymphoblastic leukemia (ALL) in 3, and mixed phenotype acute leukemia (MPAL) in 1.

Exploration and identification of diabetes targets in nursing: CDH1 and DVL1.

Diabetes is a chronic disease caused by absolute or relative insufficiency of insulin secretion and impaired insulin utilization. CDH1 and DVL1 role in diabetes and its nursing care is unclear. The diabetes dataset GSE21321 and GSE19790 profiles were downloaded from the gene expression omnibus (GEO) database.

EnNet: Enhanced Interactive Information Network with Zero-Order Optimization.

Interactive image segmentation extremely accelerates the generation of high-quality annotation image datasets, which are the pillars of the applications of deep learning. However, these methods suffer from the insignificance of interaction information and excessively high optimization costs, resulting in unexpected segmentation outcomes and increased computational burden. To address these issues, this paper focuses on interactive information mining from the network architecture and optimization procedure.

Luteolin-Loaded Hyaluronidase Nanoparticles with Deep Tissue Penetration Capability for Idiopathic Pulmonary Fibrosis Treatment.

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease characterized by sustained fibrotic lesions. Orally administered drugs usually fail to efficiently penetrate the interstitial tissue and reach the lesions, resulting in low treatment efficiency. Luteolin (Lut) is a natural flavonoid, active metabolites of which possess antioxidant, anti-inflammatory, anti-fibrotic, and anti-apoptotic properties.

Vaccine Potency and Structure of Yeast-Produced Polio Type 2 Stabilized Virus-like Particles.

Poliovirus (PV) is on the brink of eradication due to global vaccination programs utilizing live-attenuated oral and inactivated polio vaccines. Recombinant PV virus-like particles (VLPs) are emerging as a safe next-generation vaccine candidate for the impending polio-free era. In this study, we investigate the production, antigenicity, thermostability, immunogenicity, and structures of VLPs derived from PV serotype 2 (PV2) wildtype strain and thermally stabilized mutant (wtVLP and sVLP, respectively).

Initial trajectory design of low-thrust spacecraft considering attitude constraints.

The fuel carried by deep space exploration spacecraft is crucial for the completion of their exploration missions, and the fuel for attitude control engines is even more precious. In order to reduce the control requirements for attitude control systems, this paper proposes a shape-based trajectory optimization algorithm that considers attitude constraints for low-thrust spacecraft. This method obtains a more accurate transfer trajectory by considering the change rate and change range constraints of the propulsion acceleration direction of spacecraft.

Imidacloprid affects human cells through mitochondrial dysfunction and oxidative stress.

Given their relatively low persistence and mammalian toxicity, neonicotinoid pesticides have been extensively used worldwide and are omnipresent in the environment. Recent studies have shown that neonicotinoids may pose adverse effects on non-target organisms other than the known neurotoxicity, raising emerging concerns that these insecticides might pose human health risk through additional toxicity pathways. In the present study, the mitochondria function, oxidative stress, DNA damages, and genes transcription levels were examined in the human neuroblastoma SH-SY5Y cells after 48-h exposure to imidacloprid at concentrations from 0.

Exploration of port environmental efficiency measurement and influential factors in the Yangtze River Delta Pilot Free Trade Zone.

This study focuses on the environmental efficiency of ports in China's Yangtze River Delta Pilot Free Trade Zone (YRD PFTZ), a critical factor in advancing the high-quality development of ports and facilitating Chinese-style modernization. Current research on port efficiency primarily focuses on the geographical level, with relatively few studies examining the economic regional framework. We selected the YRD PFTZ port for our study to address this gap.

Association between dietary inflammatory index and fecal incontinence in American adults: a cross-sectional study from NHANES 2005-2010.

Objective: Recent studies have demonstrated that the Dietary Inflammatory Index (DII) is relevant to abnormal gut health. However, there is a lack of studies that have explicitly explored the link between fecal incontinence (FI) and DII. The current study aims to explore the relationship between DII and FI.

Analysis of asthma incidence and mortality rates among children aged 0-14 in 204 countries from 1990 to 2019.

Objective: Asthma is a common chronic respiratory disease in children. Understanding incidence and mortality trends is crucial for prevention and intervention strategies.

Methods: Data from the Global Burden of Disease (GBD) study were used to analyze asthma incidence and mortality trends among children aged 0-14 in 204 countries from 1990 to 2019.

The Effects of Combined Treatments of Laser Engraving, Plasma Spraying and Resin Pre-Coating on Improving the Bonding Strength of Titanium Alloy and Carbon Fiber-Reinforced Polymer.

This study focused on effective methods of laser engraving treatment (LET), plasma spraying, and resin pre-coating (RPC) to manufacture the reinforced adhesive joints of titanium alloy and carbon fiber-reinforced polymer (TA-CFRP) composites. The combined treatments contributed to the creation of a better adhesive bonding condition and offer a vertical gap between circular protrusions to form epoxy pins and carbon nanotube (CNT)-reinforced epoxy pins. The bonding strength of the TA-CFRP composite was reinforced by 130.

Structure and Bioactivity of Intracellular and Extracellular Polysaccharides of Mycelium.

polysaccharides have a high medicinal value; however, we still know little about the structure and bioactivity of intracellular and extracellular polysaccharides in the mycelial liquid fermentation of . This study analyzed the structures of intracellular (IP-1, IP-2, and IP-3) and extracellular (EP-1 and EP-2) polysaccharide components isolated from liquid fermentation, as well as investigated their antioxidant, antibacterial, and immunomodulatory properties. The results showed that IP-3 was the only component with a triple-helix structure, while the other four components did not possess this structure.