Publications by authors named "Cheng Cheng Shen"
Article Synopsis
- The Xishuangbanna (XIS) cucumber is a unique semiwild variety with distinct agronomic traits, and researchers used Nanopore sequencing technology to assemble a high-quality genome for the landrace XIS49.
- A comparison with the Chinese Long (CL) variety identified over 10,000 structural variations, confirming key traits related to spine, tubercle, and carpel number in XIS49.
- Two quantitative trait loci (QTLs) for hypocotyl elongation under low light were fine-mapped: SH3.1, linked to the Phytochrome B gene, and SH6.1, linked to a zinc finger protein, displaying how specific genetic elements influence cucumber growth in
Article Synopsis
- Long non-coding RNAs (lncRNAs) play important roles in cancer, with LOXL1-AS1 identified as a pro-oncogene in various tumors, particularly ovarian cancer.
- The study finds that LOXL1-AS1 is highly expressed in ovarian cancer tissue compared to adjacent non-cancerous tissue and interacts with miR-18b-5p and its target gene, VMA21.
- Results show that silencing LOXL1-AS1 or mimicking miR-18b-5p inhibits ovarian cancer cell growth and aggressiveness, indicating that LOXL1-AS1 promotes cancer cell proliferation and metastasis through a miR-18b-5p/VMA21 pathway.
AMD3100 treatment attenuates pulmonary angiogenesis by reducing the c-kit (+) cells and its pro-angiogenic activity in CBDL rat lungs.
Biochim Biophys Acta Mol Basis Dis
March 2018
Recent studies have shown that pulmonary angiogenesis is an important pathological process in the development of hepatopulmonary syndrome (HPS), and growing evidence has indicated that Stromal cell-derived factor 1/C-X-C chemokine receptor type 4 (SDF-1/CXCR4) axis is involved in pulmonary vascular disease by mediating the accumulation of c-kit+ cells. This study aimed to test the effect of AMD3100, an antagonist of CXCR4, in HPS pulmonary angiogenesis. Common bile duct ligation (CBDL) rats were used as experimental HPS model and were treated with AMD3100 (1.
View Article and Find Full Text PDFHepatopulmonary syndrome (HPS) is a complication of severe liver disease. It is characterized by an arterial oxygenation defect. Recent studies have demonstrated that pulmonary angiogenesis contributes to the abnormal gas exchange found in HPS.
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