Per- and polyfluoroalkyl substances (PFAS) have raised significant concerns; however, their accurate detection in aqueous environments remains a major challenge. In this study, a host-guest molecularly imprinted polymer-based electrochemical sensor with enhanced antifouling properties were developed using β-cyclodextrin embedded with methylene blue (βCD-MB MIP). This sensor demonstrated sensitive and selective quantification of perfluorooctanoic acid (PFOA) in real water samples.
View Article and Find Full Text PDFBackground: Managing postoperative pain following median sternotomy has long been a notable challenge for anesthesiologists. The administration of postoperative analgesia traditionally relies on intravenous pumps for the delivery of opioids. With the development of regional block techniques and postoperative multimodal analgesia, pecto-intercostal fascial block (PIFB) has gained widespread utilization due to its distinctive advantages.
View Article and Find Full Text PDFEncapsulin nanocompartments loaded with dedicated cargo proteins via unique targeting peptides, play a key role in stress resistance, iron storage and natural product biosynthesis. Mmp1 and cysteine desulfurase (Enc-CD) have been identified as the most abundant representatives of family 2 encapsulin systems. However, the molecular assembly, catalytic mechanism, and physiological functions of the Mmp1 encapsulin system have not been studied in detail.
View Article and Find Full Text PDFA single Raman spectrum reflects limited molecular information. Effective fusion of the Raman spectra of serum and urine source domains helps to obtain richer feature information. However, most of the current studies on immunoglobulin A nephropathy (IgAN) based on Raman spectroscopy are based on small sample data and low signal-to-noise ratio.
View Article and Find Full Text PDFAim: To study functional brain abnormalities in patients with eye trauma (ET) and to discuss the pathophysiological mechanisms of ET.
Methods: Totally 31 ET patients and 31 healthy controls (HCs) were recruited. The age, gender, and educational background characteristics of the two groups were similar.
Aim: To establish a meaningful standard for diagnosing ocular metastasis (OM) in menopausal breast cancer (BC) women, and explore the relationship between CA-153, CA-125, apolipoprotein A, and OM.
Methods: A total of 1362 menopausal female BC patients with OM volunteered to take part in this study between July 2012 and July 2022. Women with BC who are menopausal were found to have an OM incidence of 1.
Introduction: We aimed to identify additional predictors of severe fever with thrombocytopenia syndrome (SFTS), which has a significantly increasing global incidence.
Methods: This retrospective study included 95 patients with SFTS and 30 healthy individuals. Complete blood count with differential was performed using Sysmex XN 9000 and Mindray BC-6800 Plus analyzers.
Crit Rev Food Sci Nutr
December 2024
N-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) are essential for physiological requirements and disease prevention throughout life but are not adequately consumed worldwide. Dietary supplementation with plant-derived α-linolenic acid (ALA) has the potential to rebalance the fatty acid profile and enhance health benefits but faces challenges such as high β-oxidation consumption, low hepatic conversion efficiency, and high oxidative susceptibility under stress. This review focuses on the metabolic fate and potential regulatory targets of ALA-containing lipids , specifically the pathway from the gastrointestinal tract to the lymph, blood circulation, and liver.
View Article and Find Full Text PDFLand surface temperature (LST) is a critical parameter for understanding climate change and maintaining hydrological balance across local and global scales. However, existing satellite LST products face trade-offs between spatial and temporal resolutions, making it challenging to provide all-weather LST with high spatiotemporal resolution. In this study, focusing on Chengdu city, a framework combining a spatiotemporal fusion model and machine learning algorithm was proposed and applied to retrieve hourly high spatial resolution LST data from Chinese geostationary weather satellite data and multi-scale polar-orbiting satellite observations.
View Article and Find Full Text PDFThe generation of vector beams using metasurfaces is crucial for the manipulation of light fields and has significant application potential, ranging from classical physics to quantum science. This paper introduces a novel dielectric metasurface composed of quarter-wave plate (QWP) meta-atoms, known as a QWP metasurface, designed to generate focused vector beams (VBs) of Bell-like states under right circularly polarized illumination. The propagation phase imparted on both the co- and cross-polarized components of the output field constructs hyperbolic and helical phase profiles with topological charge , whereas the Pancharatnam-Berry (PB) phase acts only on the cross-polarized component to construct another helical phase profile with topological charge .
View Article and Find Full Text PDF: Congenital hypothyroidism (CH) is a common metabolic disorder in children that can impact growth and neurodevelopment, particularly during infancy and early childhood. DUOXA2, a DUOX maturation factor, plays a crucial role in the maturation and activation of dual oxidase DUOX2 (a member of the NADPH oxidase family). DUOX2 can correctly migrate to the plasma membrane from the endoplasmic reticulum (ER) with the help of DUOXA2, and the two proteins together form a stable complex that promotes hydrogen peroxide (H2O2) generation in the synthesis of thyroid hormones.
View Article and Find Full Text PDFA novel, to the best of our knowledge, frequency offset estimation (FOE) scheme is proposed and demonstrated for coherent digital subcarrier multiplexing (DSCM) systems, where frequency offset (FO) leads to severe filtering damage of subcarriers due to bandwidth limitations. The scheme exploits the symmetry of the signal spectrum, which naturally arises from the transmitter's frequency response and introduces frequency skewness as a cost function to search for FO. To achieve fast FOE, the false position (FP) method is employed to iteratively compute frequency shifts.
View Article and Find Full Text PDFCarbon dots are emerging luminescent nanomaterials that have drawn considerable attention due to their abundance, environmental friendliness, and customizable optical properties. However, their susceptibility to temperature-induced vibrational exciton changes and the tendency to thermal quenching of emission have hindered their practical applications. Here, a method is reported for achieving high-temperature photoluminescence carbonized polymer dots (CPDs) through a bi-confinement approach that involves a highly cross-linked polymer network and a rigid AlO matrix.
View Article and Find Full Text PDFAnionic redox has emerged as a transformative paradigm for high-energy layered transition-metal (TM) oxide cathodes, but it is usually accompanied by the formation of anionic redox-mediated oxygen vacancies (OVs) due to irreversible oxygen release. Additionally, external factor-induced OVs (defined as intrinsic OVs) also play a pivotal role in the physicochemical properties of layered TM oxides. However, an in-depth understanding of the interplay between intrinsic and anionic redox-mediated OVs and the corresponding regulation mechanism of the dynamic evolution of OVs is still missing.
View Article and Find Full Text PDFPurpose: As a globally popular physical activity, swimming also presents challenges due to its inherent aquatic risks. Therefore, the cultivation of swimming competence emerges as a crucial strategy in preventing drowning incidents. This study aimed to develop and validate the Swimming Competence Assessment Scale in College Students (SCAS) to address the gap in structured swimming proficiency evaluation, essential for drowning prevention and water safety education.
View Article and Find Full Text PDFThe unusual properties of superconductivity in magic-angle twisted bilayer graphene (MATBG) have sparked considerable research interest. However, despite the dedication of intensive experimental efforts and the proposal of several possible pairing mechanisms, the origin of its superconductivity remains elusive. Here, by utilizing angle-resolved photoemission spectroscopy with micrometre spatial resolution, we reveal flat-band replicas in superconducting MATBG, where MATBG is unaligned with its hexagonal boron nitride substrate.
View Article and Find Full Text PDFInvestigating ultraviolet (UV) birefringent crystals is a focal point of research in recent years. The development of superior birefringent materials faces substantial challenges, primarily due to the need to pinpoint optimal fundamental building blocks and to perfect their geometric arrangement within the crystal lattice. By selecting a planar π-conjugated [C(NH)] group and a staggered [SO] group, we have successfully synthesized an organic-inorganic hybrid crystal, [C(NH)]SO.
View Article and Find Full Text PDFDuring chronic infection or tumorigenesis, persistent antigen stimulation contributes to the exhaustion of CD8 T cells. Nevertheless, exhausted CD8 T (T) cells still preserve certain effector function, and maintaining a reservoir of exhausted cells is of vital importance for virus elimination and tumor eradiation. Despite considerable work interrogating the rejuvenation of T cells, mechanisms underpinning the clonal deletion of T cells remain largely unexplored over the past decade.
View Article and Find Full Text PDFMoS is a promising sulfur host material for lithium-sulfur (Li-S) batteries, but its low conductivity and limited active edge sites largely inhibit the catalytic activity toward the conversion of lithium polysulfides (LiPSs). Herein, we propose an electron bridge strategy by combining interlayer structure modification and electronic modulation to activate the basal-plane catalytic activity of MoS for the highly efficient catalytic conversion of LiPSs. As validated by experimental characterizations and theoretical calculations, the proposed strategy not only creates a conductive network but also induces delocalized electron redistribution within the MoS basal planes, leading to facilitated interfacial charge transfer kinetics and accelerated LiPSs redox kinetics.
View Article and Find Full Text PDFMelanoma is a common malignant skin tumor with highly invasive features and a high metastasis rate that can be difficult to treat clinically. Large-scale resection of primary cutaneous melanoma is often used to avoid postoperative recurrence. For advanced patients, radiotherapy, targeted therapy and immunotherapy are often needed.
View Article and Find Full Text PDFBackground: Avascular necrosis of femoral head and malunion are frequent post-operative complications of femoral neck fractures. To optimize surgical techniques, this study aims to provide a microstructural understanding of intraosseous microvasculature and the trabecular bone of the femoral head and neck.
Study Design: This anatomical study analyzed twenty-eight femora from fourteen cadaveric beagles.
Comput Methods Programs Biomed
November 2024
Background And Objectives: Cerebrovascular segmentation plays a crucial role in guiding the diagnosis and treatment of cerebrovascular diseases. With the rapid advancements in deep learning models, significant progress has been made in 3D cerebrovascular segmentation. However, they often rely on massive images and annotations, which is still challenging in cerebrovascular segmentation.
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