6-Gingerol microneedle promotes diabetic wound healing by regulating macrophage polarization.

Diabetic wound-healing difficulties are common for patients with diabetes. Compared to normal wound healing processes, the hyperglycaemic environment in diabetic wounds increases the proportion of M1 macrophages significantly, thereby prolonging the inflammatory phase of wound healing. Consequently, treatment approaches targeting macrophages are gaining increasing attention in both research and clinical practice.