Nucleic acid drugs: recent progress and future perspectives.

High efficacy, selectivity and cellular targeting of therapeutic agents has been an active area of investigation for decades. Currently, most clinically approved therapeutics are small molecules or protein/antibody biologics. Targeted action of small molecule drugs remains a challenge in medicine.

Organoplatinum Complex Exhibiting Aggregation-Enhanced Emission (AEE) and Dual-Channel Ion-Sensing Properties by Terminating the Molecular Configuration Transformation (MCT) and Excited-State Intramolecular Proton Transfer (ESIPT).

Emitters produce weak emissions when they undergo structural changes such as molecular configuration transformation (MCT) or excited-state intramolecular proton transfer (ESIPT) but give out strong emissions after terminating these distortions. Herein, an organoplatinum complex, , carrying a salicylaldehyde-based Schiff base unit is synthesized. It exhibits weak emission in dilute solutions but shows bright emission at the aggregated state or after interacting with F and Zn.

B-cell lymphoma with cytokine storm in serosal effusion: A case report and literature review.

Rationale: Cytokine storm is now considered to be a systemic inflammatory response, but local cytokine storm may exist in systemic diseases of the blood system. Monitoring of regional cytokine storm is an important clue for the diagnosis of systemic diseases.

Patient Concerns: A 72-years-old male presented to our hospital with multiple serosal effusion without solid mass or enlarged lymph nodes.

Exploration of effective biomarkers and infiltrating Immune cells in Osteoarthritis based on bioinformatics analysis.

Osteoarthritis (OA) is a multi-factorial chronic joint disease mainly identified by synovial inflammation, cartilage damage, and degeneration. Our study applied bioinformatics analysis to uncover the immunity in OA and tried to explore the underlying immune-related molecular mechanism. First, OA-related gene-expression profiling data were retrieved from GEO database.

Family capital, social stratification, and access to higher education: An empirical study in mainland China.

This paper employs Bourdieu's theory of capital-focusing on family cultural, social, and economic capital-to research the early-stage mechanism through which access to higher education is formed. While all three types of capital play a significant role in acquiring higher education, most studies tend to focus on just one type of capital. In recent years, domestic scholars have also analyzed in detail the family factors affecting children's access to higher education (CAHE); however, they have not yet explained the mechanism by which these factors influence CAHE, and authentic tests are rare.

Identification and antibiotic resistance of Cronobacter spp. isolated from dried edible mushrooms.

Cronobacter spp. is an important foodborne pathogen that can cause life-threatening diseases in infants and immunocompromised adults. The present study was carried out to understand the prevalence and characterization of Cronobacter spp.

Significantly Increased Public Interest in Major Depressive Disorder During the COVID-19 Pandemic: Insights From a Google Trends Analysis.

Background As early as before the coronavirus disease 2019 (COVID-19) pandemic, nearly one billion people worldwide suffered from mental health problems. Of all the mental health conditions, major depressive disorder (MDD) is the leading cause of global health-related burden. During the COVID-19 pandemic, many uncertain factors affecting mental health accumulated, such as virus transmission, blockade and ban, public transport restrictions, closure of schools and enterprises, and reduction of social interaction, which led to an increase in the potential risk of MDD, further increasing the global health-related burden.

Micropeptide MIAC Inhibits HNSCC Progression by Interacting with Aquaporin 2.

Several important micropeptides encoded by noncoding RNAs have been identified in recent years; however, there have never been any reports of micropeptides in head and neck squamous cell carcinoma (HNSCC). Here we report the discovery and characterization of a human endogenous peptide named micropeptide inhibiting actin cytoskeleton (MIAC). Comprehensive analysis of the TCGA (The Cancer Genome Atlas) database ( = 500), clinical fresh samples ( = 94), and tissue microarrays ( = 60) revealed that lower MIAC expression is correlated with poor overall survival of HNSCC patients.

A novel arthritis model induced by wind, damp, cold and heat in female rats.

Animal models are in constant development to benefit scientific research. Rheumatoid arthritis (RA) is considered a very complex disease due to its complicated pathogenesis, and patients with rheumatic disease around the world are still unable to obtain effective, simple and curable treatment. In order to obtain a clear insight into the pathogenesis of RA, a rat model was established based on the concept of syndrome in Traditional Chinese Medicine by simulating the conditions of RA as much as possible via the change in the physical conditions wind, damp, cold and heat (WDCH).

Differentially Private Distributed Online Learning.

In the big data era, the generation of data presents some new characteristics, including wide distribution, high velocity, high dimensionality, and privacy concern. To address these challenges for big data analytics, we develop a privacy-preserving distributed online learning framework on the data collected from distributed data sources. Specifically, each node (i.

Peptide PD29 treats bleomycin-induced pulmonary fibrosis by inhibiting the TGF-β/smad signaling pathway.

Pulmonary fibrosis (PF) is an end-stage change in lung disease characterized by fibroblast proliferation, massive extracellular matrix (ECM) aggregation with inflammatory damage, and severe structural deterioration. PD29 is a 29-amino acid peptide which has the potential to alleviate PF pathogenesis via three mechanisms: anti-angiogenesis, inhibition of matrix metalloproteinase activities, and inhibition of integrins. In this study, fibrotic lung injuries were induced in SD rats by a single intratracheal instillation of 5 mg/kg bleomycin (BLM).

Facile Synthesis and Cytotoxicity of Phenazine-Chromene Hybrid Molecules Derived from Phenazine Natural Product.

Aim And Objective: Small molecule targeted drugs can effectively reduce the toxicity and side effects of drugs, and improve the efficacy of drugs by their specific antitumor activity. Hence, the development of small molecular targeted drugs for cancer has important significance. This study was undertaken to design and synthesize novel phenazine-chromene hybrid molecules in order to optimize the structure and improve the efficacy of this kind of hybrids.

Clinical impact of circulating miR-26a, miR-191, and miR-208b in plasma of patients with acute myocardial infarction.

Background: Aberrant expression of several types of miRNAs has been reported in acute myocardial infarction (AMI). The objective of our study was to compare miRNA expression in AMI patients and normal healthy people and determine whether miR-26a, miR-191, and miR-208b could be measured in plasma as indicators for AMI.

Methods: Detection of AMI patients and normal persons by using miRNA microarray chip analysis and miR-26a, miR-191, and miR-208b was screened out.