Publications by authors named "Chenchen Zang"
Article Synopsis
- Hua-Shi-Bai-Du decoction (HSBD) shows promise in treating COVID-19 by impacting the NLRP3 inflammasome activation, which is crucial in the disease's pathology.
- The study aims to investigate HSBD's effects on NLRP3 activation using both in vitro and in vivo models, assessing various molecular and cellular responses.
- Results indicate that HSBD effectively reduces inflammatory cytokines like IL-1β by inhibiting ASC oligomerization, preserving intracellular cAMP levels, and blocking phosphodiesterase 4B (PDE4B) activity, showcasing its potential as a therapeutic option for COVID-19.
Objective: Inulicin is a sesquiterpene lactone in Inulae Flos which is clinically used for the treatment of inflammatory diseases, such as cough, sputum production, and vomiting. This study aimed to demonstrate the anti-inflammatory activity and the underlying mechanism of inulicin by using lipopolysaccharide (LPS)-induced and models.
Methods: LPS-stimulated RAW264.
Article Synopsis
- Scutellarein, found in certain plants, exhibits anti-inflammatory and anti-oxidative properties and has the potential to alleviate lung inflammation, particularly in acute lung injury (ALI).
- The study demonstrated that scutellarein reduces harmful reactive oxygen species (ROS) in human bronchial cells and lowers levels of pro-inflammatory cytokines, effectively inhibiting key pathways responsible for inflammation.
- In mouse models of ALI, scutellarein significantly decreased inflammatory markers in lung fluid and reduced damage, suggesting its potential use in treating conditions like infectious pneumonia.
Ethnopharmacological Relevance: The meridian (GuiJing) theory is a unique theory of traditional Chinese medicine (TCM) which has been guiding the clinical practice of TCM for thousands of years, but physiological foundation of TCM's meridian remains to be clarified. Recent investigations have marked gut microbiota as a key mediator for the pharmacological effects of various TCMs. However, most studies focus on the response of gut microbes to a single drug or formula, the interactive effects of different drugs on gut microbiota are scarcely investigated.
View Article and Find Full Text PDFThe property theory is a unique principle instructing traditional Chinese doctors to prescribe proper medicines against diseases. As an essential part of it, the five-flavor theory catalogs various Chinese materia medicas (CMMs) into five flavors (sweet, bitter, sour, salty, and pungent) based on their taste and medical functions. Although CMM has been successfully applied in China for thousands of years, it is still a big challenge to interpret CMM flavor via modern biomarkers, further deepening its elusiveness.
View Article and Find Full Text PDFCoptidis Rhizoma exhibits potent effects on ameliorating metabolic disease through modulation of gut bacteria. Gut fungi play a significant role on the homeostasis of the intestinal microecosystem and several types of metabolic disorders. Previous studies have mainly concentrated on the function of bacteria on the beneficial effects of Coptidis Rhizoma and its main component berberine, but whether gut fungi are linked to the improvement of glycolipid metabolism disorder of Coptidis Rhizoma is not clear.
View Article and Find Full Text PDFBackground: It is necessary to systematically evaluate the efficacy and adverse reactions of pirfenidone in the treatment of patients with idiopathic pulmonary fibrosis (IPF).
Methods: Pubmed et al. databases were searched up to March 15, 2021 for randomized controlled trials (RCT) of pirfenidone in the treatment of IPF.