Synopsis of recent research by authors named "Chenchang Liu"
Chenchang Liu's research primarily focuses on the molecular mechanisms regulating organic anion transporters (OATs) in the kidneys, which are critical for drug disposition and elimination, impacting pharmacology and toxicology.
Recent studies demonstrate the involvement of protein kinase C (PKC) and ubiquitin ligases such as Nedd4-2 in the internalization and stability of these transporters, particularly OAT1 and OAT3.
Liu's work highlights the significant role of drug-drug interactions mediated by OATs, emphasizing the clinical relevance of understanding these transport mechanisms for improving therapeutic outcomes.
