Publications by authors named "Chencen Zhang"
In this study, we aimed to uncover novel biomarkers in acute myeloid leukemia (AML) that could serve as prognostic indicators or therapeutic targets. We analyzed AML microarray datasets from the Gene Expression Omnibus (GEO) repository, identifying key differentially expressed genes (DEGs) through the robust rank aggregation (RRA) approach. The functions of these DEGs were elucidated through Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses.
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- The study investigates how Weitiao No. 3 (WD-3) affects the efficacy of anti-PD-1 immunotherapy in gastric cancer by analyzing the gut microbiota of healthy individuals, gastric cancer patients, and those treated with WD-3.
- It found significant differences in gut bacteria compositions across the groups, highlighting a decrease in beneficial bacteria and an increase in those associated with treatment.
- Moreover, both WD-3 and anti-PD-1 treatments enhanced T-cell responses while reducing regulatory T cells, leading to inhibited tumor cell growth and increased apoptosis in gastric cancer models.