Publications by authors named "ChenYi Wu"
Background: Growing evidence has shown that cholesterol metabolism abnormalities involve carcinogenesis. Proprotein convertase subtilisin/kexin type-9 (PCSK9) inhibitors have been reported to inhibit tumor progression and prevent ultraviolet-related skin damage.
Objective: To investigate the association of PCSK9 inhibitors with the risk of nonmelanoma skin cancer (NMSC).
Background: The administration of the COVID-19 vaccine has been linked to the development of herpes zoster (HZ). However, studies examining the clinical outcomes in COVID-19 vaccination-associated and non-COVID-19 vaccination-associated HZ are lacking.
Objective: To investigate the risk of postherpetic neuralgia (PHN) in COVID-19 vaccination associated HZ.
Background: Tumor-associated neutrophils (TANs) constitute an abundant component among tumor-infiltrating immune cells and have recently emerged as a critical player in pancreatic ductal adenocarcinoma (PDAC) progression. This study aimed to elucidate the pro-tumor mechanisms of TAN and identify a novel target for effective immunotherapy against PDAC.
Methods: Microarray and cytokine array analyses were performed to identify the mechanisms underlying the function of TANs.
The periodontal tissue regeneration strategy based on guided tissue regeneration (GTR) membranes is an effective therapy for periodontal defects. Traditional GTR membranes, however, primarily serve as physical barriers and lack antimicrobial and osteogenic functions. Herein, we developed a multifunctional nanofiber membrane with zeolitic imidazolate framework-8 nanoparticles (ZIF-8 NPs) loaded in a hydrophilic gelatin layer.
View Article and Find Full Text PDFBackground: Air pollution is associated with several inflammatory skin disorders. However, the association between air quality and rosacea remains unclear.
Objectives: To investigate the association between the Air Quality Index (AQI) and incidence of rosacea.
Background: Although immune checkpoint blockade (ICB) therapy has proven to be extremely effective at managing certain cancers, its efficacy in treating pancreatic ductal adenocarcinoma (PDAC) has been limited. Therefore, enhancing the effect of ICB could improve the prognosis of PDAC. In this study, we focused on the histamine receptor H1 (HRH1) and investigated its impact on ICB therapy for PDAC.
View Article and Find Full Text PDFThe clinical implications of extrachromosomal DNA (ecDNA) in cancer therapy remain largely elusive. Here, we present a comprehensive analysis of ecDNA amplification spectra and their association with clinical and molecular features in multiple cohorts comprising over 13,000 pan-cancer patients. Using our developed computational framework, GCAP, and validating it with multifaceted approaches, we reveal a consistent pan-cancer pattern of mutual exclusivity between ecDNA amplification and microsatellite instability (MSI).
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- Air pollutants may worsen atopic dermatitis (AD), but the link between Air Quality Index (AQI) and AD incidence was unclear until this study.
- Researchers analyzed data from over 21 million people in Taiwan, finding that higher AQI levels correlated with an increased risk of developing AD.
- The study showed a clear dose-response relationship: as AQI worsened, the risk of AD rose significantly, suggesting that even small increments in AQI can elevate the chance of developing the condition.
Background: Vitiligo is reportedly associated with several ocular abnormalities. However, the relationship between vitiligo and retinal detachment (RD) remains unclear.
Objectives: To examine the risk of RD in patients with vitiligo.
Background: Tocilizumab has demonstrated optimal efficacy and safety in patients with rheumatoid arthritis (RA) from clinical trials. However, the risk of hepatitis B virus reactivation (HBVr) in these patients remains uncertain because patients with underlying HBV have been excluded in phase III studies.
Methods: Systematical reviews were conducted on PubMed, Embase, and the Cochrane Central Register of Controlled Trials up to 21 February 2023.
Background And Aim: Transcatheter liver-directed intra-arterial therapies are mainstream treatment options for intermediate-stage hepatocellular carcinoma (HCC). However, the effect of low skeletal muscle mass (LSMM) on overall survival (OS) in these patients remains uncertain. We aimed to ascertain the prevalence and prognostic effect of LSMM in this population.
View Article and Find Full Text PDFIntroduction: Atopic dermatitis (AD) is a disease frequently occurring in children. The immune response is characterized by T-helper (Th)-2-dependent inflammation. Type 1 diabetes mellitus (T1DM) is an autoimmune disease that destroys pancreatic islet beta cells.
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- - Studies indicate a link between chronic kidney disease (CKD) and an increased risk of bullous pemphigoid (BP), but this association is still not fully understood.
- - Research involving over a million participants in Taiwan revealed that CKD significantly raises the risk of developing BP, with dialysis-dependent patients facing the highest risk.
- - The findings suggest that individuals with CKD have a 1.3 times greater risk of BP, while those on dialysis have a 1.8 times greater risk compared to those without CKD.
We aimed to develop an accurate and efficient skin cancer classification system using deep-learning technology with a relatively small dataset of clinical images. We proposed a novel skin cancer classification method, SkinFLNet, which utilizes model fusion and lifelong learning technologies. The SkinFLNet's deep convolutional neural networks were trained using a dataset of 1215 clinical images of skin tumors diagnosed at Taichung and Taipei Veterans General Hospital between 2015 and 2020.
View Article and Find Full Text PDFIn virtue of the advantages, such as aesthetics, designability, convenient removal, and comfortable experience, invisible orthodontics (IO) have been widely recognized and accepted by the public. However, most of the membranes currently used for IO only meet the requirement of shape retention. Other vital functions, like antibacterial and antifouling activities, are neglected.
View Article and Find Full Text PDFUnlabelled: Gastric cancer is one of the most frequent cancers in the world. Emerging clinical data show that ubiquitination system disruptions are likely involved in carcinoma genesis and progression. However, the precise role of ubiquitin (Ub)-mediated control of oncogene products or tumor suppressors in gastric cancer is unknown.
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- * Researchers found that about 1.8% of patients experienced severe flares with hepatic decompensation within four years after discontinuing NUCs, with higher risks for those with cirrhosis, portal hypertension, older age, and male sex.
- * The findings suggest that stopping NUC therapy should be approached cautiously in clinical practice, as severe complications can occur in a small percentage of patients.
Article Synopsis
- Patients with bullous pemphigoid have a high risk of serious infections, which are the main cause of mortality in this group, with about 40.7% developing such infections within two years of diagnosis.
- The study identified strong associations between serious infections and factors like systemic corticosteroid use, advanced age, female sex, low income, and specific comorbidities, with patients being twice as likely to experience infections compared to controls.
- The findings emphasize the need for targeted interventions to manage risk factors and potentially reduce the serious health impacts associated with bullous pemphigoid.
Low skeletal muscle mass (LSMM) is associated with poor outcomes in hepatocellular carcinoma (HCC) patients. With the emergence of new systemic therapeutics, understanding the effect of LSMM on HCC treatment outcomes is critically important. This systematic review and meta-analysis investigates the prevalence and effect of LSMM among HCC patients undergoing systemic therapy as reported in studies identified in searches of the PubMed and Embase databases published through 5 April 2023.
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