NSvc4 Encoded by Rice Stripe Virus Targets Host Chloroplasts to Suppress Chloroplast-Mediated Defense.

Our previous research found that NSvc4, the movement protein of rice stripe virus (RSV), could localize to the actin filaments, endoplasmic reticulum, plasmodesmata, and chloroplast, but the roles of NSvc4 played in the chloroplast were opaque. Here, we confirm the accumulation of NSvc4 in the chloroplasts and the N-terminal 1-73 amino acids of NSvc4 are sufficient to localize to chloroplasts. We provide evidence to show that chloroplast-localized NSvc4 can impair the chloroplast-mediated immunity.

The Impact of Symptom Severity on Health-Related Quality of Life in People with Narcolepsy Type 1.

Objective: To assess the impact of symptom severity on health-related quality of life (HRQoL) in people with narcolepsy type 1 (NT1).

Methods: A total of 174 people with NT1 were enrolled. They completed the Narcolepsy Severity Scale (NSS) and EQ-5D-3L consisting of five dimensions (EQ-5D utility values) and a visual analog scale (EQ-5D VAS).

Transcriptome analysis of grass carp (Ctenopharyngodon idella) and Holland's spinibarbel (Spinibarbus hollandi) infected with Ichthyophthirius multifiliis.

Ichthyophthirius multifiliis is a protozoan ciliate that causes white spot disease (also known as ichthyophthiriasis) in freshwater fish. Holland's spinibarbel (Spinibarbus hollandi) was less susceptible to white spot disease than grass carp (Ctenopharyngodon Idella). In this study, grass carp and Holland's spinibarbel are infected by I.

Unveiling radial breathing mode in a particle-on-mirror plasmonic nanocavity.

Plasmonic radial breathing mode (RBM), featured with radially oscillating charge density, arises from the surface plasmon waves confined in the flat nanoparticles. The zero net dipole moment endows the RBM with an extremely low radiation yet a remarkable intense local field. On the other hand, owing to the dark mode nature, the RBMs routinely escape from the optical measurements, severely preventing their applications in optoelectronics and nanophotonics.

Corrigendum to "miR-486 Promotes the Invasion and Cell Cycle Progression of Ovarian Cancer Cells by Targeting CADM1".

[This corrects the article DOI: 10.1155/2021/7407086.].

Theoretical Calculation of Core-Excited States along Dissociative Pathways beyond Second-Order Perturbation Theory.

We extend the multireference driven similarity renormalization (MR-DSRG) method to compute core-excited states by combining it with a GASSCF treatment of orbital relaxation and static electron correlation effects. We consider MR-DSRG treatments of dynamical correlation truncated at the level of perturbation theory (DSRG-MRPT2/3) and iterative linearized approximations with one- and two-body operators [MR-LDSRG(2)] in combination with a spin-free exact-two-component (X2C) one-electron treatment of scalar relativistic effects. This approach is calibrated and tested on a series of 16 core-excited states of five closed- and open-shell diatomic molecules containing first-row elements (C, N, and O).

Rice stripe virus activates the bZIP17/28 branch of the unfolded protein response signalling pathway to promote viral infection.

The unfolded protein response (UPR) plays important roles in plant virus infection. Our previous study has proved that rice stripe virus (RSV) infection elicits host UPR. However, the mechanism on how the UPR is triggered upon RSV infection remains obscure.

Analytic Energy Gradients for the Driven Similarity Renormalization Group Multireference Second-Order Perturbation Theory.

We derive analytic energy gradients of the driven similarity renormalization group (DSRG) multireference second-order perturbation theory (MRPT2) using the method of Lagrange multipliers. In the Lagrangian, we impose constraints for a complete-active-space self-consistent-field reference wave function and the semicanonical orthonormal molecular orbitals. Solving for the associated Lagrange multipliers is found to share the same asymptotic scaling of a single DSRG-MRPT2 energy computation.

A Novel Rice Curl Dwarf-Associated Picornavirus Encodes a 3C Serine Protease Recognizing Uncommon EPT/S Cleavage Sites.

Picornaviruses cause diseases in a wide range of vertebrates, invertebrates and plants. Here, a novel picornavirus was identified by RNA-seq technology from rice plants showing dwarfing and curling symptoms, and the name rice curl dwarf-associated virus (RCDaV) is tentatively proposed. The RCDaV genome consists of an 8,987 nt positive-stranded RNA molecule, excluding a poly(A) tail, that encodes two large polyproteins.

Parity and risk of developing breast cancer according to tumor subtype: A systematic review and meta-analysis.

Background: Clinical breast cancer subtypes are categorized basing on the expression of hormone receptors and overexpression of the human epidermal growth factor receptor 2 (HER2). It is still unclear whether parity impact the risk of different breast cancer subtypes.

Methods: We searched eight mainstream databases for published epidemiologic studies that assessed the relationship between parity and risk of breast cancer subtypes up to January 12, 2021.

Influence of Dietary Behaviors on Dyslipidemia in Pregnant Women and Its Effects on Physical Development of Fetuses and Infants: A Bidirectional Cohort Study.

Background: Gestational diabetes can alter the trajectory of fetal development, but there are few studies on the effects of abnormal lipid metabolism on physical development of infants. We aimed to explore the prevalence of maternal dyslipidemia, its influencing factors and effects on the physical development of fetuses and infants, as well as the role of leptin in this process.

Methods: Questionnaire surveys and main outcome measures were administered among 338 pairs of pregnant women and newborns.

Narcolepsy Quality-of-Life Instrument with 21 Questions: A Translation and Validation Study in Chinese Pediatric Narcoleptics.

Objective: This study aimed to translate and validate the narcolepsy quality-of-life instrument with 21 questions (NARQoL-21) in Chinese pediatrics with narcolepsy.

Methods: NARQoL-21 was translated following the 10 steps of scale translation. The translated version was tested by exploratory factor analysis (EFA), confirmatory factor analysis (CFA), known-group validity, criterion validity, Cronbach's α and test-rest reliability.

A self-sacrifice template strategy to synthesize Co-LDH/MXene for lithium-ion batteries.

To overcome the limitations of both LDHs and MXenes, we develop a self-sacrifice template strategy using a zeolite imidazolate framework-67 (ZIF-67) to derive Co-LDH anchored on an MXene conductive substrate (Co-LDH/MXene). In this process, ZIF-67 grows on the MXene nanosheets, then spontaneously transforms into Co-LDH/MXene in aqueous solution at room temperature. As the LIB anode, it shows a reversible capacity of 854.

Antitumour effect of odoroside A and its derivative on human leukaemia cells through the ROS/JNK pathway.

Oleandrigenin-3-O-β-D-diginoside (a derivative of odoroside A), isolated and purified by our group, has seldom been explored for its pharmacological activity. This study aimed at clarifying the mechanisms towards the leukaemia-suppressive role of odoroside A (compound #1) and its derivative, oleandrigenin-3-O-β-D-diginoside (compound #2) isolated from Nerium oleander. Viability and nuclear morphology change were assessed by CCK-8 assay and fluorescence microscope, respectively.

Vitamin A alleviates heat stress-induced damage to hair follicle development in Rex rabbits.

Background: Rex rabbits are important fur rabbits. Heat stress severely reduces the fur quality of Rex rabbits. The aim of this study was to experimentally investigate the effect of dietary vitamin A (VA) addition on hair follicle development and related signal pathways in Rex rabbits under heat stress.

Saponins from Nigella glandulifera seeds attenuate collagen-induced rheumatoid arthritis in rats via the OPG/RANKL/NF-κB and Ang/Tie-2 pathways.

Ethnopharmacological Relevance: Nigella glandulifera Freyn et Sint. (N. glandulifera) seeds are widely used in traditional Uyghur medicine for a variety of immuno-inflammatory diseases.

Mechanism of Ulcerative Colitis-Aggravated Liver Fibrosis: The Activation of Hepatic Stellate Cells and TLR4 Signaling Through Gut-Liver Axis.

The progression of liver disorders is frequently associated with inflammatory bowel disease through the gut-liver axis. However, no direct evidence showed the mechanisms of ulcerative colitis (UC) in the development of liver fibrosis . Thus, this study aimed to evaluate the effects of UC on liver fibrosis and its potential mechanism in the experimental model.

Spin-free formulation of the multireference driven similarity renormalization group: A benchmark study of first-row diatomic molecules and spin-crossover energetics.

We report a spin-free formulation of the multireference (MR) driven similarity renormalization group (DSRG) based on the ensemble normal ordering of Mukherjee and Kutzelnigg [J. Chem. Phys.

The first record of the monospecific genus (Lepidoptera: Nymphalidae) from China.

Background: The family Nymphalidae is the largest group of butterflies with high species richeness. (Cramer, [1779]), a forest species, was discovered in the mid-stream of the Yuanjiang-Red River Valley of Yunnan Province for the first time, which represents the first record of the genus in China.

New Information: The species (Cramer, [1779]) is the first record of the genus from China.

Dietary lysine supplementation improves growth performance and skeletal muscle development in rabbits fed a low protein diet.

The purpose of this study was to investigate the effects on growth of Lysine (Lys) supplementation in a low protein diet. We also investigated the gene or protein expression related to skeletal muscle development and intestinal amino acid transporters, and determined the major signalling associated with Lys-regulating skeletal muscle development. 1000 healthy, weights averaging 938.

Efficacy and Safety of Janus Kinase Inhibitors for the Treatment of Atopic Dermatitis: A Systematic Review and Meta-Analysis.

Background: Current therapeutic options for atopic dermatitis (AD) are limited. Janus kinase (JAK) inhibitors may be viable alternatives.

Objectives: To assess the efficacy and safety of JAK inhibitors for AD treatment.

The month of birth has a seasonal effect in Chinese patients with narcolepsy and cataplexy.

Study Objectives: We assessed the yearly seasonal, environmental effects on birth pattern in Chinese patients later diagnosed with narcolepsy and cataplexy and explored if this effect persisted in patients with symptoms onset date before, following, and after the 2009 H1N1 pandemic.

Methods: A total of 1,942 patients with birth data information and diagnosed narcolepsy with cataplexy were included in this study. The birth month and seasonal effect of 1,064 patients born from 1970 to 2000 were compared to controls (n = 2,028,714) from the general population.

miR-486 Promotes the Invasion and Cell Cycle Progression of Ovarian Cancer Cells by Targeting CADM1.

Objective: To explore the role and possible underlying mechanism of miR-486 in ovarian cancer (OC) cells.

Methods: The expression of miR-486 and CADM1 was detected by qRT-PCR in OC tissues and adjacent nontumor tissues and OC cell lines. The dual-luciferase reporter gene system was used to determine the targeting relationship between miR-486 and CADM1.