Publications by authors named "ChenGuang Wang"

The method of power prior has long been used as a tool for leveraging external data to augment a traditional clinical study. More recently, it has been found that integrating propensity scoring into its application has the potential for improved operating characteristics. In this paper, we introduce a new propensity score-integrated power prior strategy which uses propensity score weighting and is distinctive from other such proposals in the literature.

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The research examines the challenges city street sweepers face, which struggles to adapt cleaning settings based on varying road garbage volume, resulting in inefficient cleaning and high energy consumption. The study proposes a fuzzy control algorithm for adjusting the cleaning parameters of street sweepers based on road garbage volume grading. It starts by utilizing the YOLO (You Only Look Once) v5 deep learning model for target detection and garbage classification on road surfaces.

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The accurate assessment of platelet activity is crucial in clinical practice and scientific research owing to the pivotal role of platelets in the progression of cardiovascular conditions, such as arterial thrombotic diseases. However, conventional platelet activity assessment methods are currently limited by their requirement of substantial blood samples and inadequate high-throughput capabilities, and therapeutic resistance induced by antiplatelet agents impedes treatment efficacy. In this study, we developed a microdroplet-based platelet function detection method, referred to as NebulaPlate, to achieve miniaturized and robust platelet activity assessment, thereby overcoming current challenges.

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Rapeseed and sorghum, important economic crops in China, generate abundant straw resources. However, studies examining the effects of straw return combined with reduced nitrogen fertilization on soil quality are still insufficient to meet the precise fertilization needs, necessitating further research. This study employed two treatments: rapeseed straw plus sorghum straw (LT) and rapeseed green manure plus sorghum straw (YGT) returned to the soil.

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Fusarium head blight (FHB), caused by Fusarium graminearum, severely affects wheat yield and quality. Fludioxonil, a phenylpyrrole fungicide, is commonly used in the control of FHB. In this study, strains with histidine kinase amino acid substitutions (M402V, M541I, L915M), conferring resistance to fludioxonil, were identified in Hangzhou, Zhejiang Province, China.

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In oncology clinical trials, tumor burden (TB) stands as a crucial longitudinal biomarker, reflecting the toll a tumor takes on a patient's prognosis. With certain treatments, the disease's natural progression shows the tumor burden initially receding before rising once more. Biologically, the point of change may be different between individuals and must have occurred between the baseline measurement and progression time of the patient, implying a random effects model obeying a bound constraint.

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Advanced microwave technologies constitute the foundation of a wide range of modern sciences, including microwave integrated circuits, quantum computing, microwave photonics, spintronics, etc. To facilitate the design of chip-based microwave devices, there is an increasing demand for state-of-the-art microscopic techniques that are capable of characterizing near-field microwave distribution and performance. In this work, we integrate Josephson junctions onto a nanosized quartz tip, forming a highly sensitive microwave mixer on-tip.

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Tabletability is a key property that determines a powder's ability to form tablets under applied stresses, typically represented by a plot of tablet tensile strength versus pressure. Tablet tensile strength reflects the contributions of interparticulate bonding area (BA) and bonding strength (BS) between adjacent particles in a tablet. BA is influenced by mechanical properties, particle characteristics, and tableting conditions, while BS is governed by molecular packing and intermolecular interactions.

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Purpose: To evaluate the efficacy and complications of simplified graded inferior oblique anterior transposition (IOAT) in treating at least 10 PD vertical deviation in the primary position and inferior oblique muscle overaction (IOOA).

Methods: This retrospective study reviewed the medical records of 65 patients treated with simplified graded IOAT procedures for both vertical deviation and IOOA. Patients were grouped according to vertical deviation in the primary position.

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Salt formation has been extensively used to modulate and improve the properties of active pharmaceutical ingredients (API), such as solubility, stability and mechanical properties. Tablets of the anti-angina drug, trimetazidine (TMZ) are currently manufactured using the wet granulation process, rather than the more cost-effective direct compression method. In an effort to address the two main challenges associated with the commercial dihydrochloride salt (TMZ-2HCl), i.

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With the rising prevalence of lithium-ion batteries, efficient recovery of metal ions, particularly those potentially released from LiFePO anodes, has become critical. Given that both Fe and Li ions can form electrostatic adsorptive interactions, achieving effective separation of conventional adsorbent materials becomes challenging. This study presents an amino acid-functionalized nanocellulose hydrogel (ANH) synthesized by incorporating L-threonine, which significantly enhances the selective adsorption of Fe in a mixed-ion environment by leveraging coordination differences between Li and Fe.

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White adipose tissue (WAT) beiging holds significant therapeutic potential for combating obesity. Here, we present a protocol for inducing beige WAT in mice using both cold exposure and CL316,243 treatment. We describe steps for intraperitoneal injection, and subcutaneous WAT (sWAT) isolation, dissection, and fixation.

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Pancreatic cancer (PC) is one of the most lethal digestive system tumors. Claudin18.2 is highly expressed in PC tissue and could serve as a suitable target for CAR-T therapy.

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One of the most significant advances in stimulated emission depletion (STED) super-resolution microscopy is its capacity for dynamic super-resolution imaging of living cells, including the long-term tracking of interactions between various cells or organelles. Consequently, the multicolor STED plays a pivotal role in biological research. Despite the emergence of numerous fluorescent probes characterized by low toxicity, high stability, high brightness, and exceptional specificity, enabling dynamic imaging of living cells with multicolor STED, practical implementation of multicolor STED for live-cell imaging is influenced by several factors.

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The catalytic efficiency of natural enzymes depends on the precise electronic interactions between active centers and cofactors within a three-dimensional (3D) structure. Single-atom nanozymes (SAzymes) attempt to mimic this structure by modifying metal active sites with molecular ligands. However, SAzymes struggle to match the catalytic efficiency of natural enzymes due to constraints in active site proximity, quantity, and the inability to simulate electron transfer processes driven by internal electronic structures of natural enzymes.

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Interest in oral delivery of biological drug products, commonly prepared through lyophilization, is surging. Typically, low solid content solutions are employed for lyophilization to enhance mass transfer and minimize drying time. Yet, this approach often results in lyophilized powders with low bulk density and poor flowability, challenging downstream processing steps that are required for oral product development.

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Background: At present, there is a lack of efficient biomarkers for the diagnosis of thyroid cancer, and the influence of natural factors such as high iodine exposure on the expression of biomarkers remains unclear.

Methods: Serum samples from papillary thyroid cancer (PTC) and non-cancer controls matched 1:1 in different iodine nutritional regions were analyzed metabolomically using an ultra-high performance liquid chromatography-Orbitrap Exploris mass spectrometry (UHPLC-OE-MS) platform. Then the data were randomly divided into training and test sets in a 1:1 ratio according to the different iodine nutritional regions and different PTC status.

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Cancer vaccines have garnered considerable interest for cancer immunotherapy. However, their effectiveness is limited by inadequate proliferation, activation, and tumor infiltration of cytotoxic T lymphocytes (CTLs). Inspired by the potent immunostimulatory properties of viral components and the exposure of calreticulin during immunogenic cell death (ICD) triggered by viral infections; in this study, we describe cGAMP@vEVs, a virus-mimicking nanovaccine strategy by engineering tumor cell-derived extracellular vesicles through virus infection, which co-load both personalized and broad antigen repertoire as well as multiple immune adjuvants to potently elicit antitumor immunity.

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Article Synopsis
  • The study analyzed open globe injury (OGI) cases in children under six, involving 106 patients predominantly male (57.5%) with an average age of 4.14 years.
  • Sharp objects were the leading cause of OGI, primarily affecting the right eye and resulting in various complications, including traumatic cataracts and endophthalmitis.
  • Fast medical intervention post-injury can reduce the risk of complications like endophthalmitis, highlighting the need for better awareness and strategies to mitigate injury severity in young children.
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The transcription factor GATA-binding protein 3 (GATA-3) and the transcriptional program it regulates have emerged as oncogenic drivers across diverse T-cell lymphomas (TCLs), many of which are resistant to conventional chemotherapeutic agents and characterized by recurrent losses of key tumor suppressor genes, including TP53 and PTEN, both of which are clients of the nuclear export protein XPO1. Here, we demonstrated that XPO1 is highly expressed by malignant T cells expressing GATA-3 and by lymphoma-associated macrophages (LAMs) within their tumor microenvironment (TME). Using complementary genetically engineered mouse models, we demonstrated that TP53- and/or phosphate and tensin homolog (PTEN)-deficient TCLs, and LAMs within their TME, are sensitive to the selective exportin-1 (XPO1) antagonist selinexor.

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Rainwater harvesting is a viable solution for providing clean water in regions where conventional water sources are scarce or contaminated. However, the harvested rainwater often contains microorganisms, suspended particles, and other impurities that must be removed before consumption. Gravity-driven ceramic membranes (GDCMs) are an efficient choice for purifying harvested rainwater due to their energy-saving properties.

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Fusarium head blight (FHB), caused by Fusarium graminearum, is a devastating disease that severely affects crop yield and quality worldwide. The catabolite responsive elements A (CreA) plays a critical role in numerous cellular processes in eukaryotes. In this study, we performed a functional characterization of CreA in F.

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Fusarium head blight (FHB), caused by , severely impacts global wheat production, reducing both the yield and quality. In China, fludioxonil, a phenylpyrrole fungicide, is used for managing FHB. This study assessed fludioxonil activity against 120 strains collected from Hubei, Zhejiang, and Jiangsu in 2024, revealing an average EC value of 0.

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Ethnopharmacological Relevance: Colorectal cancer (CRC) is a prevalent malignant tumor of the digestive tract. Traditional Chinese medicine (TCM) has a long history of treating CRC, with advantages such as effectiveness, multi-target, multi-pathway, and minimal side effects. TCM Magnolia officinalis (M.

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Article Synopsis
  • Respiratory viruses pose significant health risks, but the exact immune mechanisms behind respiratory virus-induced lung injuries remain unclear.
  • Using a specialized human alveolus chip, researchers tracked how macrophages respond to influenza A virus infection, discovering that these immune cells transition through different phases that contribute to acute lung injury (ALI) and pulmonary fibrosis (PF).
  • The study reveals that the initial macrophage response to infection leads to inflammation and damage, followed by a transformation process that promotes healing but may also contribute to detrimental conditions like PF, providing essential insights for developing future treatments for respiratory virus infections.
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