sp Carbon Disrupting Axial Symmetry of Local Electric Field for Biomimetic Construction of Three-Dimensional Geometric and Electronic Structure in Nanozyme.

The catalytic efficiency of natural enzymes depends on the precise electronic interactions between active centers and cofactors within a three-dimensional (3D) structure. Single-atom nanozymes (SAzymes) attempt to mimic this structure by modifying metal active sites with molecular ligands. However, SAzymes struggle to match the catalytic efficiency of natural enzymes due to constraints in active site proximity, quantity, and the inability to simulate electron transfer processes driven by internal electronic structures of natural enzymes.

Impact of solid content on the bulk properties of lyophilized powders.

Interest in oral delivery of biological drug products, commonly prepared through lyophilization, is surging. Typically, low solid content solutions are employed for lyophilization to enhance mass transfer and minimize drying time. Yet, this approach often results in lyophilized powders with low bulk density and poor flowability, challenging downstream processing steps that are required for oral product development.

Study on identification of diagnostic biomarkers in serum for papillary thyroid cancer in different iodine nutrition regions.

Background: At present, there is a lack of efficient biomarkers for the diagnosis of thyroid cancer, and the influence of natural factors such as high iodine exposure on the expression of biomarkers remains unclear.

Methods: Serum samples from papillary thyroid cancer (PTC) and non-cancer controls matched 1:1 in different iodine nutritional regions were analyzed metabolomically using an ultra-high performance liquid chromatography-Orbitrap Exploris mass spectrometry (UHPLC-OE-MS) platform. Then the data were randomly divided into training and test sets in a 1:1 ratio according to the different iodine nutritional regions and different PTC status.

Engineered virus-mimicking nanovaccine with lymph node-tumor dual-targeting and STING-activating capacity for robust cancer immunotherapy.

Cancer vaccines have garnered considerable interest for cancer immunotherapy. However, their effectiveness is limited by inadequate proliferation, activation, and tumor infiltration of cytotoxic T lymphocytes (CTLs). Inspired by the potent immunostimulatory properties of viral components and the exposure of calreticulin during immunogenic cell death (ICD) triggered by viral infections; in this study, we describe cGAMP@vEVs, a virus-mimicking nanovaccine strategy by engineering tumor cell-derived extracellular vesicles through virus infection, which co-load both personalized and broad antigen repertoire as well as multiple immune adjuvants to potently elicit antitumor immunity.

Characteristics of open globe injury in children under six.

Introduction: This study aimed to analyse the clinical characteristics of open globe injury (OGI) in children under six.

Methods: A retrospective analysis was conducted on the medical data of children with OGI admitted to the Eye Center of the Second Hospital of Jilin University, China, between 1 January 2012 and 31 December 2020.

Results: The study included 106 children, with 61 males (57.

The GATA-3-dependent transcriptome and tumor microenvironment are regulated by eIF4E and XPO1 in T-cell lymphomas.

The transcription factor GATA-3 and the transcriptional program it regulates have emerged as oncogenic drivers across diverse T-cell lymphomas (TCL), many of which are resistant to conventional chemotherapeutic agents and characterized by recurrent losses of key tumor suppressor genes, including TP53 and PTEN, both of which are clients of the nuclear export protein XPO1. Here we demonstrated that XPO1 is highly expressed by malignant T cells expressing GATA-3 and by lymphoma-associated macrophages (LAM) within their tumor microenvironment (TME). Using complementary genetically engineered mouse (GEM) models, we demonstrated that TP53 and/or PTEN deficient TCL, and LAM within their TME, are sensitive to the selective XPO1 antagonist selinexor.

Purification of harvested rainwater using gravity-driven ceramic membrane: A visualization study combining Micro-CT and COMSOL simulations.

Rainwater harvesting is a viable solution for providing clean water in regions where conventional water sources are scarce or contaminated. However, the harvested rainwater often contains microorganisms, suspended particles, and other impurities that must be removed before consumption. Gravity-driven ceramic membranes (GDCMs) are an efficient choice for purifying harvested rainwater due to their energy-saving properties.

The transcription factor FgCreA modulates ergosterol biosynthesis and sensitivity to DMI fungicides by regulating transcription of FgCyp51A and FgErg6A in Fusarium graminearum.

Fusarium head blight (FHB), caused by Fusarium graminearum, is a devastating disease that severely affects crop yield and quality worldwide. The catabolite responsive elements A (CreA) plays a critical role in numerous cellular processes in eukaryotes. In this study, we performed a functional characterization of CreA in F.

A Novel Point Mutation M460I in Histidine Kinase FgOs1 Confers High Resistance to Fludioxonil in .

Fusarium head blight (FHB), caused by , severely impacts global wheat production, reducing both the yield and quality. In China, fludioxonil, a phenylpyrrole fungicide, is used for managing FHB. This study assessed fludioxonil activity against 120 strains collected from Hubei, Zhejiang, and Jiangsu in 2024, revealing an average EC value of 0.

Effect and mechanism of Magnolia officinalis in colorectal cancer: Multi-component-multi-target approach.

Ethnopharmacological Relevance: Colorectal cancer (CRC) is a prevalent malignant tumor of the digestive tract. Traditional Chinese medicine (TCM) has a long history of treating CRC, with advantages such as effectiveness, multi-target, multi-pathway, and minimal side effects. TCM Magnolia officinalis (M.

Monitoring the Cascade of Monocyte-Derived Macrophages to Influenza Virus Infection in Human Alveolus Chips.

Respiratory viruses ravage the world and seriously threaten people's health. Despite intense research efforts, the immune mechanism underlying respiratory virus-induced acute lung injury (ALI) and pulmonary fibrosis (PF) has not been fully elucidated. Here, the cascade of monocyte-derived macrophages to influenza A virus infection is monitored on an optimized human alveolus chip to reveal the role of macrophages in the development of ALI and PF.

Efficient Aerial Water Harvesting with Self-Sensing Dynamic Janus Crystals.

Water scarcity is one of the most pressing issues of contemporary societal development that requires innovative technologies where the material not only harvests water but also plays an active role in the process. Here, we demonstrate a highly efficient optical self-sensing approach to humidity capture from the air, where both humidity-harvesting and water-transduction functionalities are imparted on slender organic crystals by partial silanization via layer-by-layer hybridization. We report that due to the integration of the harvesting of aerial moisture and the collection of the condensed water, the ensuing Janus-type crystals capture humidity with the highest-to-date water collection efficiency of 15.

Intelligent Bionic Polarization Orientation Method Using Biological Neuron Model for Harsh Conditions.

We developed an intelligent innovative orientation method to improve the accuracy of polarization compasses in harsh conditions: weak skylight polarization patterns resulting from unfavorable weather conditions (e.g., haze, sandstorms) or locally destroyed skylight polarization conditions caused by occlusions (e.

A cross domain access control model for medical consortium based on DBSCAN and penalty function.

Graded diagnosis and treatment, referral, and expert consultations between medical institutions all require cross domain access to patient medical information to support doctors' treatment decisions, leading to an increase in cross domain access among various medical institutions within the medical consortium. However, patient medical information is sensitive and private, and it is essential to control doctors' cross domain access to reduce the risk of leakage. Access control is a continuous and long-term process, and it first requires verification of the legitimacy of user identities, while utilizing control policies for selection and management.

A Randomized, Double-Blind, Parallel-Group Phase I Study Comparing the Pharmacokinetics, Safety, and Immunogenicity of CMAB015, a Candidate Secukinumab Biosimilar, with Its Reference Product Cosentyx in Healthy Chinese Male Subjects.

Purpose: Secukinumab, a monoclonal antibody targeting interleukin (IL)-17A, is approved for the treatment of psoriasis, psoriatic arthritis, ankylosing spondylitis, non-radiographic axial spondyloarthritis, enthesitis-related arthritis, and hidradenitis suppurativa. This study compared the pharmacokinetics (PK), safety, and immunogenicity of CMAB015, a candidate secukinumab biosimilar, with the reference product secukinumab (Cosentyx) in healthy Chinese male subjects.

Patients And Methods: This double-blind, parallel-group study randomized healthy Chinese male subjects (N=130) to receive either a single dose of 150 mg CMAB015 or secukinumab subcutaneously.

An innovative deformation coordination method for analyzing distortion effects on box girders.

A deformation coordination method is proposed in this study to account for the distortion effects on a box girder. The differential equation for distortion in vertical web box girders is derived based on the deformation coordination condition of the distortion angle, considering both external loads and internal forces. Subsequently, a comparative analysis is conducted to explore the similarities and differences between the differential equations derived from the proposed deformation coordination method, the plate element analysis method and the total potential energy variation method.

Labeling selectivity of lipid droplets fluorescent probes: Twisted intramolecular charge transfer (TICT) vs intramolecular charge transfer (ICT).

Fluorescence imaging technology is a versatile and essential tool in the field of biomedical research. To obtain excellent imaging results, the precise labeling of fluorescent probes is an important prerequisite. Nevertheless, the labeling selectivity of most fluorescent probes is not satisfactory, new design concepts are desperately needed.

Stanniocalcin 2 governs cancer cell adaptation to nutrient insufficiency through alleviation of oxidative stress.

Solid tumours often endure nutrient insufficiency during progression. How tumour cells adapt to temporal and spatial nutrient insufficiency remains unclear. We previously identified STC2 as one of the most upregulated genes in cells exposed to nutrient insufficiency by transcriptome screening, indicating the potential of STC2 in cellular adaptation to nutrient insufficiency.

Overexpression of from Affects the Photosynthetic Physiology and Endogenous Hormones of Tobacco.

Kunitz trypsin inhibitor genes play important roles in stress resistance. In this study, we investigated cloned from and its effect on tobacco. was introduced into the tobacco cultivar NC89 using -mediated transformation.

Diverse functions and pathogenetic role of Crumbs in retinopathy.

The Crumbs protein (CRB) family plays a crucial role in maintaining the apical-basal polarity and integrity of embryonic epithelia. The family comprises different isoforms in different animals and possesses diverse structural, localization, and functional characteristics. Mutations in the human CRB1 or CRB2 gene may lead to a broad spectrum of retinal dystrophies.

Enhancing Global Estimation of Fine Particulate Matter Concentrations by Including Geophysical Information in Deep Learning.

Global fine particulate matter (PM) assessment is impeded by a paucity of monitors. We improve estimation of the global distribution of PM concentrations by developing, optimizing, and applying a convolutional neural network with information from satellite-, simulation-, and monitor-based sources to predict the local bias in monthly geophysical PM concentrations over 1998-2019. We develop a loss function that incorporates geophysical estimates and apply it in model training to address the unrealistic results produced by mean-square-error loss functions in regions with few monitors.

Integrated and DC-powered superconducting microcomb.

Frequency combs, specialized laser sources emitting multiple equidistant frequency lines, have revolutionized science and technology with unprecedented precision and versatility. Recently, integrated frequency combs are emerging as scalable solutions for on-chip photonics. Here, we demonstrate a fully integrated superconducting microcomb that is easy to manufacture, simple to operate, and consumes ultra-low power.

Macrophage membrane-coated nanoparticles for the treatment of infectious diseases.

Infectious diseases severely threaten human health, and traditional treatment techniques face multiple limitations. As an important component of immune cells, macrophages display unique biological properties, such as biocompatibility, immunocompatibility, targeting specificity, and immunoregulatory activity, and play a critical role in protecting the body against infections. The macrophage membrane-coated nanoparticles not only maintain the functions of the inner nanoparticles but also inherit the characteristics of macrophages, making them excellent tools for improving drug delivery and therapeutic implications in infectious diseases (IDs).