[The effects of mechanical ventilation with different tidal volumes on the expression of caveolin-1 in lung tissue and its related downstream signaling in rats].

Objective: To investigate the expression of caveolin-1 (cav-1) and its downstream signal under mechanical ventilation with different tidal volumes (VT) in lung tissue of rats.

Methods: Forty healthy male Sprague-Dawley (SD) rats were randomly assigned into five groups (each n=8). The rats in control group (group A) remained to have spontaneous breathing but underwent tracheostomy only.