Publications by authors named "Chen-Yu Li"

Objective: To evaluate the prognostic impact of primary surgery on patients with HPV-independent, advanced or metastatic endocervical adenocarcinoma (EAC) who typically exhibit poor survival outcomes and resistance to conventional therapies such as chemoradiotherapy.

Methods: A bi-institutional retrospective study was conducted at Samsung Medical Center and Taiwan National University Hospital. Between 2001 and 2023, 92 patients with HPV-independent advanced or metastatic EAC were included.

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Purpose: As understanding of the molecular pathogenesis of endometrial carcinoma (EC) advanced, the International Federation of Gynecology and Obstetrics (FIGO) staging system was revised in 2023. This study compared EC survival outcomes using the 2009 and 2023 FIGO staging systems.

Materials And Methods: We retrospectively analyzed 3,029 patients diagnosed with 2009 FIGO stage I-III EC between 1985 and 2022 in South Korea, and between 2020 and 2022 in Taiwan.

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Developing hydrogels with high conductivity and toughness a facile strategy is important yet challenging. Herein, we proposed a new strategy to develop conductive hydrogels by growing metal dendrites. Water-soluble Sn ions were soaked into the gel and then converted to Sn dendrites an electrochemical reaction; the excessive Sn ions were finally removed by water dialysis, accompanied by dramatic shrinkage of the gel.

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Skin cancers continue to present unresolved challenges, particularly regarding the association with sex hormones, which remains a topic of controversy. A systematic review is currently warranted to address these issues. To analyze if sex hormones result in a higher incidence of skin cancers (cutaneous melanoma, basal cell carcinoma, squamous cell carcinoma).

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Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease which afflicts about nearly 1% of global population. RA results in synovitis and cartilage/bone damage, even disability which aggravates the health burden. Many drugs are used to relieve RA, such as glucocorticoids (GCs), non-steroidal anti-inflammatory drugs (NSAIDs), and disease-modifying anti-rheumatic drugs (DMARDs) in the clinical treatment.

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Article Synopsis
  • Touch displays are common but current protective methods for flexible screens are bulky and limit design potential.
  • Researchers have developed a new organic-inorganic hybrid coating that combines various protective functions into a single layer.
  • This innovative coating is not only multifunctional—offering optical clarity, flexibility, and scratch resistance—but is also eco-friendly due to its recyclability, making it ideal for future technology.
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Recent research has indicated that formononetin demonstrates a potent anti-inflammatory effect in various diseases. However, its impact on sterile inflammation kidney injury, specifically acute kidney injury (AKI), remains unclear. In this study, we utilized an ischemia/reperfusion-induced AKI (IRI-AKI) mouse model and bone marrow-derived macrophages (BMDMs) to investigate the effects of formononetin on sterile inflammation of AKI and to explore the underlying mechanism.

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Background: To examine the application of quantitative 2-dimensional phase-contrast MRI (2D PC-MRI) for treating patients with pelvic congestion syndrome (PCS).

Materials And Methods: The authors conducted a retrospective cross-sectional analysis by using quantitative 2D PC-MRI data enrolled between April 2017 and September 2023. In addition, 32 healthy female controls (HCs) were included.

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  • This study looked at women with a health issue called atypical endometrial hyperplasia (AEH) who didn't get better after 3 months of treatment with a hormone called progestin.
  • Most of the women who continued the treatment improved after about a year, especially if they took higher doses of progestin.
  • However, some women had the problem come back later, and being overweight was linked to a higher chance of this happening. Overall, the study suggests that continuing treatment can still help these patients.
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  • Researchers created a heart-on-a-chip model to study how SARS-CoV-2 affects heart function, especially in patients with existing heart conditions, using human stem cell-derived heart cells.
  • The study found that COVID-19 caused significant heart damage, worsening when combined with angiotensin II, leading to reduced heart contractions and increased inflammation.
  • Extracellular vesicles from stem cells showed potential to protect heart function by reducing damage and enhancing certain gene activities, with specific microRNAs identified as key factors in this protective effect.
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The substantial economic impact of non-healing wounds, scarring, and burns stemming from skin injuries is evident, resulting in a financial burden on both patients and the healthcare system. This review paper provides an overview of the skin's vital role in guarding against various environmental challenges as the body's largest protective organ and associated developments in biomaterials for wound healing. We first introduce the composition of skin tissue and the intricate processes of wound healing, with special attention to the crucial role of immunomodulation in both acute and chronic wounds.

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Different eukaryotic cell organelles (e.g., mitochondria, endoplasmic reticulum, lysosome) are involved in various cancer processes, by dominating specific cellular activities.

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Gu-Sui-Bu, the dried rhizome of , is a traditional Chinese herbal remedy with a significant history of treating osteoporosis and inflammatory conditions. However, its potential as an anti-influenza agent and its underlying mechanisms of action remain unexplored. To obtain a more potent extract from and gain insights into its mechanism of action against influenza A virus (IAV), we utilized a partitioning process involving organic solvents and water, resulting in the isolation of butanolic subfractions of the extract (DMBE).

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Background: Fertility-sparing surgery (FSS) is an alternative choice of young patients who have not completed their family planning and still have fertility needs. The aims of this study were to compare the outcomes of early-stage epithelial ovarian cancer (EOC) patients undergoing FSS and radical comprehensive staging surgery (RCS), and the suitability of FSS.

Methods: A total of 1297 patients aged between 20 and 44 years with newly diagnosed early-stage EOC were recruited from the Taiwan Cancer Registry database between 2009 and 2017.

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  • Researchers studied how a medicine called ribociclib, usually used for cancer, might help with a serious lung condition called ARDS that is caused by too many active immune cells.
  • They tested ribociclib on human immune cells and in mice to see how it works to reduce harmful inflammation and stress in the lungs.
  • The results showed that ribociclib helped lower inflammation and lung damage, suggesting it could be a new way to treat ARDS and similar problems.
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Viral RNA-dependent RNA polymerase (RdRp), a highly conserved molecule in RNA viruses, has recently emerged as a promising drug target for broad-acting inhibitors. Through a Vero E6-based anti-cytopathic effect assay, we found that BPR3P0128, which incorporates a quinoline core similar to hydroxychloroquine, outperformed the adenosine analog remdesivir in inhibiting RdRp activity (EC = 0.66 µM and 3 µM, respectively).

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Keloids, pathological scars resulting from skin trauma, have traditionally posed significant clinical management challenges due to their persistence and high recurrence rates. Our research elucidates the pivotal roles of lipids and their derivatives in keloid development, driven by underlying mechanisms of abnormal cell proliferation, apoptosis, and extracellular matrix deposition. Key findings suggest that abnormalities in arachidonic acid (AA) synthesis and non-essential fatty acid synthesis are integral to keloid formation.

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  • The study investigates the effectiveness of different adjuvant treatments in patients with early-stage endometrial cancer, specifically those classified as 2023 FIGO stage IIC, where aggressive tumor types pose greater risks.
  • Researchers analyzed outcomes from 272 patients, noting that adjuvant treatment did not generally improve recurrence-free survival (RFS) or overall survival (OS), but it showed benefits for specific groups, including those with lymphovascular space invasion (LVSI) and grade 3 endometrioid types.
  • The findings suggest that while adjuvant treatment may not be universally beneficial, it could improve OS for certain high-risk patients, leading to considerations for personalized treatment strategies.
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The Eucalyptus tree, belonging to the myrtle family, grows all over the world for its pharmaceutical and industrial benefits. In this article, we present a comparative analysis of the chemical composition of the hydrodistilled oils obtained from three different Eucalyptus species growing in Egypt viz. , , and .

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  • - A new fluorescent probe called 4-AHBI was created, which is based on a modified benzimidazole structure.
  • - This probe showed very high sensitivity in detecting triphosgene, with a detection limit as low as 0.08 nM, and it was able to specifically identify triphosgene among other similar chemicals.
  • - Researchers also developed test strips containing 4-AHBI, allowing for practical and easy sensing of triphosgene in real-world applications.
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Homologous recombination (HR)-mediated DNA repair is a prerequisite for maintaining genome stability. Cancer cells displaying HR deficiency (HRD) are selectively eliminated by poly(ADP-ribose) polymerase inhibitors (PARPis). To date, sequencing of HR-associated genes and analyzing genome instability have been used as clinical predictions for PARPi therapy.

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Background: Hydrogen sulfide (HS) is a recently discovered gaseous neurotransmitter in the nervous and gastrointestinal systems. It exerts its effects through multiple signaling pathways, impacting various physiological activities. The nucleus tractus solitarius (NTS), a vital nucleus involved in visceral sensation, was investigated in this study to understand the role of HS in regulating gastric function in rats.

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