Publications by authors named "Chen-Ying Jiang"
Background: Multidrug resistance (MDR) to chemotherapy drugs remains a major challenge in clinical cancer treatment. Here we investigated whether and how ginsenoside Rg5 overcomes the MDR mediated by ABCB1 transporter and .
Methods: Cytotoxicity and colon formation as well as the intracellular accumulation of ABCB1 substrates were carried out in MDR cancer cells A2780/T and A549/T for evaluating the reversal effects of Rg5.
Genetic and biochemical characterization of a 4-hydroxybenzoate hydroxylase from Corynebacterium glutamicum.
Appl Microbiol Biotechnol
February 2008
Article Synopsis
- Corynebacterium glutamicum can grow using 4-hydroxybenzoic acid (4HBA) as its only carbon source, with previous research revealing that it takes up 4HBA through the PcaK protein and breaks it down using protocatechuate 3,4-dioxygenase.* -
- The study identified the gene pobA (Cg) (ncgl1032), which encodes a 4HBA 3-hydroxylase that converts 4HBA into protocatechuate, and found that its protein product, PobA (Cg), is a homodimer that operates closely with PcaK in a potential operon setup.* - *