Publications by authors named "Chen-Yang Mi"
Nucleic Acids Res
April 2020
Article Synopsis
- The hexametric T7 helicase (gp4) wraps around a DNA strand and works to unwind it, but its exact mechanism for doing this is still not fully understood.*
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- Researchers used advanced techniques to study how gp4 interacts with DNA, especially when there are abasic lesions (missing nucleotides), and found that these lesions slow down but don't completely stop the unwinding process.*
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- The study revealed that gp4 moves back and forth more when encountering lesions and steps forward by one to four nucleotides on normal DNA, suggesting that a specific intermediate state during unwinding might help gp4 navigate around these lesions.*
