Magnetic resonance diffusion-derived vessel density (DDVD) as a valuable tissue perfusion biomarker for isocitrate dehydrogenase genotyping in diffuse gliomas.

Background: Determining isocitrate dehydrogenase (IDH) mutation is crucial for glioma clinical management. MR diffusion-derived 'vessel density' (DDVD) offers non-invasive tissue perfusion evaluation within the tumor microenvironment. The study attempts to distinguish IDH genotypes of diffuse gliomas using DDVD in whole tumor parenchyma and its habitats.