Publications by authors named "Chen-Shin Chin"
Article Synopsis
- The study utilized deep single-molecule, real-time (SMRT) sequencing to analyze two haploid human genomes, uncovering over 461,500 genetic variants, most of which were overlooked in the 1000 Genomes Project.
- These long-read sequencing techniques revealed that more than 89% of previously missed variants differ significantly from the human reference genome and are better detected compared to short-read methods.
- When constructing a pseudodiploid genome by merging the haploids, about 59% of heterozygous structural variants became undetectable, highlighting the enhanced sensitivity of haploid genome analysis for structural variant detection.
Background: Simultaneous pancreas and kidney transplantation is the treatment of choice for diabetes mellitus patients with associated end-stage renal disease. Limited vascular access could be encountered in patients with severe atherosclerosis, and/or severe obesity and in re-transplant patients. We describe a modified technique that facilitates simultaneous pancreas and kidney (SPK) composite graft transplantation with retroperitoneal systemic-enteric drainage for patients with limited vascular access.
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