[Characteristics of maxillary anterior teeth of 191 individuals living in Fujian Province].

Purpose: To investigate the anatomical characteristics of upper anterior teeth of residents in Fujian province using cone-beam CT (CBCT).

Methods: The length and width of 1146 maxillary anterior teeth (central incisors, lateral incisors, and canines) from 191 patients were measured. SPSS 19.

Design, synthesis, biological evaluation of benzoyl amide derivatives containing nitrogen heterocyclic ring as potential VEGFR-2 inhibitors.

For the purpose of synthesizing drug candidates with desirable bioactivity, a class of benzoyl amide containing nitrogen heterocyclic ring derivatives targeting VEGFR-2 was designed and screened out using Discovery Studio. Eighteen target compounds were synthesized and then selected by some biological trials sequentially including inhibition of VEGFR-2, anti-proliferation in vitro, flow cytometry. Among them, compound 8h showed the best inhibitory activity (IC = 0.

Design, synthesis, and biological evaluation of pyrazole derivatives containing acetamide bond as potential BRAF inhibitors.

With the increasingly acquired resistance, relapse and side effects of known marketed BRAF inhibitors, it's significant to design the more effective and novel drugs. In this study, a series of novel pyrazole derivatives containing acetamide bond had been designed and synthesized on the basis of analysis of the endogenous ligands extracted from the known B-Raf co-crystals in the PDB database. Then, the compounds were evaluated for biological activities as potential BRAF inhibitors.