Publications by authors named "Chen-Jun Liu"

Article Synopsis
  • - Yoga is effective in treating binge eating disorder (BED), with significant improvements in binge eating scale scores and physical fitness metrics like maximal oxygen consumption from pre-to-post intervention.
  • - High-intensity interval training (HIIT), while successful in enhancing physical fitness and body composition, does not improve BED symptoms as seen in the yoga group.
  • - Both HIIT and yoga groups showed better fitness levels compared to a control group, but yoga led to significantly lower binge eating scores, highlighting its particular benefit for BED.
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Chemerin is an adipokine that contributes to metabolism regulation. Nucleus tractus solitarius (NTS) is the first relay station in the brain for accepting various visceral afferent activities for regulating cardiovascular activity. However, the roles of chemerin in the NTS in regulating sympathetic activity and blood pressure are almost unknown.

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Article Synopsis
  • Isoleucine-proline-proline (IPP) is a natural tripeptide that inhibits angiotensin-converting enzyme (ACE), playing a role in reducing hypertension and sympathetic activity in a rat study.
  • The study involved male Sprague-Dawley rats with induced hypertension, showing that IPP injections into the brain and bloodstream effectively lowered both sympathetic nerve activity and blood pressure by mitigating ACE activity and oxidative stress.
  • Long-term treatment with IPP also led to significant reductions in hypertension and vascular changes, highlighting its potential as a therapeutic approach for managing high blood pressure.
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Article Synopsis
  • The study investigates the role of asprosin, a newly identified adipokine, in causing vascular inflammation linked to hypertension by activating the NLRP3 inflammasome.
  • Researchers used vascular smooth muscle cells (VSMCs) from hypertensive rats and various mouse models to analyze asprosin expression and its effects on inflammation and cell behavior.
  • Findings suggest that elevated asprosin levels lead to inflammation and changes in VSMCs through the TLR4-NFκB signaling pathway, indicating a potential target for hypertension treatment.
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Glucagon-like peptide-1 (GLP-1) and its analogs are widely used for diabetes treatment. The paraventricular nucleus (PVN) is crucial for regulating cardiovascular activity. This study aims to determine the roles of GLP-1 and its receptors (GLP-1R) in the PVN in regulating sympathetic outflow and blood pressure.

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Background: To compare the clinical outcomes of compressive buttress screw (CBS) fixation, a novel screw fixation strategy, to off-axial screw fixation (off-axial partial threaded cannulated screw, OPTCS) for vertical femoral neck fractures (FNFs) in young adults.

Methods: A total of 146 adults younger than 55 years old with high-energy Pauwels type III FNFs were randomized to receive CBS fixation or OPTCS fixation. Primary outcomes were complication rates, including fixation failure, fracture nonunion, and avascular necrosis of the femoral head (ANFH) at 24 months after treatment.

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Background: Assessment of the risk of pesticide inhalation in populations around farmland is necessary because inhalation is one of the ways in which pesticides can risk human health. This study aimed to identify the inhalation risk of difenoconazole on humans by using dose-response and exposure assessments.

Results: In the field simulation application, respiratory exposure in populations around farmland ranged from 71 to 430 ng/m .

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Sympathetic overactivity contributes to the pathogenesis of sepsis. The selective α2-adrenergic receptor agonist dexmedetomidine (DEX) is widely used for perioperative sedation and analgesia. We aimed to determine the central roles and mechanisms of DEX in attenuating sympathetic activity and inflammation in sepsis.

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Asprosin is a newly discovered adipokine that is involved in regulating metabolism. Sympathetic overactivity contributes to the pathogenesis of several cardiovascular diseases. The paraventricular nucleus (PVN) of the hypothalamus plays a crucial role in the regulation of sympathetic outflow and blood pressure.

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Objective: To compare the biomechanical properties of compression buttress screw (CBS) fixation with three plate fixation methods for the treatment of vertical femoral neck fractures (FNFs).

Methods: A total of forty synthetic femoral models with simulated Pauwels type III fractures (angle of 70°) were equally assigned to one of four fixation groups: CBS fixation, anteromedial plate fixation (AMP), medial buttress plate fixation (MBP) and medial buttress plate fixation without proximal screw (MBPw). Within each group, half of the specimens were randomly assigned to two loading settings, an axial compression loading test and a hip-flexion torsion test.

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Stem-end rot (SER), caused by , is one of the most critical diseases of mango in China. The demethylation inhibitor fungicide prochloraz has been widely used in China to control mango diseases. Isolates ( = 139) of were collected in 2019 from six mango-producing regions in Hainan Province, China.

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Background: In consideration of characteristics and functions, extra-cellular signal-regulated protein kinase 5 (ERK5) signaling pathway could be a new target for spinal cord injury (SCI) treatment. Our study aimed to evaluate the roles of ERK5 signaling pathway in secondary damage of SCI.

Methods: We randomly divided 70 healthy Wistar rats into five groups: ten in the blank group, 15 in the sham surgery + BIX02188 (sham + B) group, 15 in the sham surgery + dimethyl sulfoxide (DMSO; sham + D) group, 15 in the SCI + BIX02188 (SCI + B) group, and 15 in the SCI + DMSO (SCI + D) group.

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This study aims to explore the influence of bone resorption of the spinous process after single-segment interspinous process device (IPD) implantation on the biomechanics of the lumbar spine.The 3D finite element model of the lumbar spine (L3-L5) was modified, and 2 models that simulated the presence and absence of bone resorption of the spinous process were developed using an IPD (Wallis). Its biomechanical effects, such as change in range of motion (ROM) and intervertebral disc and facet stress, were introduced at operative (L4/5) and adjacent (L3/4) levels.

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Objective: To assess the mid-long-term follow-up of the safety and efficacy of anterior cervical discectomy and fusion (ACDF), cervical artificial disc replacement (CADR) and hybrid surgery (HS) for bilevel cervical degenerative disc disease (cDDD).

Methods: 77 patients who underwent ACDF, HS, and CADR were retrospectively reviewed. Clinical effects were evaluated based on Neck Disability Index (NDI), Visual Analog Scale (VAS), and Japanese Orthopedic Association (JOA) scores and the Odom criteria.

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Background: Thoracolumbar junction (TLJ) is the transitional area between the lower thoracic spine and the upper lumbar spine. Vertebral compression fractures and proximal junctional kyphosis following spine surgery often occur in this area. Therefore, the study of development and mechanisms of thoracolumbar junctional degeneration is important for planning surgical management.

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