Publications by authors named "Chen-Jie Feng"
Article Synopsis
- Knowledge-based statistical potentials are effective for evaluating and predicting protein structures, but there is a lack of comprehensive research on reference states specifically for RNA structure evaluation.
- This study created six statistical potentials using different reference states from protein analysis and tested them on three RNA datasets, finding that the finite-ideal-gas and random-walk-chain methods performed best overall.
- The results indicate that the effectiveness of these potentials is influenced by both the quality of the training sets used and the specific origins of the RNA test sets, with generally poor performance observed for realistic RNA test subsets.
Article Synopsis
- Double-stranded RNAs (dsRNAs) are crucial for cell metabolism, and understanding their 3D structure, stability, and flexibility in salt solutions helps clarify their biological roles.* -
- This study expands a coarse-grained model to accurately predict the 3D structures and thermal stability of dsRNAs in different ion conditions, improving predictions by including electrostatic potential.* -
- The model shows that the thermal stability of dsRNAs varies based on their length and sequence, and it effectively correlates predictions of dsRNA flexibility in salt solutions with experimental data.*
RNA pseudoknots are a kind of minimal RNA tertiary structural motifs, and their three-dimensional (3D) structures and stability play essential roles in a variety of biological functions. Therefore, to predict 3D structures and stability of RNA pseudoknots is essential for understanding their functions. In the work, we employed our previously developed coarse-grained model with implicit salt to make extensive predictions and comprehensive analyses on the 3D structures and stability for RNA pseudoknots in monovalent/divalent ion solutions.
View Article and Find Full Text PDF(the Chinese name is DiYu, DY) exerts significant anti-proliferative activities against colorectal cancer (CRC) cells. Since most of CRC result from the aberrant activation of the Wnt/β-catenin signaling pathway, inhibitors of the Wnt pathway are considered as promising anti-CRC agents. This study aimed to investigate whether DY could be a potential herbal Wnt inhibitor, and the bioactive constituents and underlying molecular mechanisms for DY's inhibiting activities would be studied as well.
View Article and Find Full Text PDFSanguisorba officinalis L. radix is a widely used herb called DiYu (DY) in China and has an extensive range of bioactivities, including anti-cancer, anti-inflammatory, and anti-oxidative activities. However, there is little evidence to support its anti-cancer effects against colorectal cancer (CRC).
View Article and Find Full Text PDF[Correlation between typing of peripheral neuroblastic tumors and prognosis: a clinicopathologic study of 135 cases].
Zhonghua Bing Li Xue Za Zhi
March 2011
Objective: To study the clinicopathologic characteristics of peripheral neuroblastic tumors and to investigate the prognostic significance of International Neuroblastoma Pathology Classification (INPC).
Methods: One hundred and thirty-five cases of peripheral neuroblastic tumors encountered in Shanghai Children's Medical Center were enrolled into the study. All the cases were classified according to INPC and International Neuroblastoma Staging System (INSS).