Publications by authors named "Chen-Hui Zhao"
Article Synopsis
- The study focuses on the single-nucleotide polymorphism (SNP) rs1333040 and its connection to coronary heart disease (CHD) in a Chinese population.
- Involving 500 CHD patients and 500 control subjects, the research employed case-control methods to analyze genotype differences and their statistical significance related to CHD risk.
- Findings suggest that the T allele of rs1333040 increases CHD risk, particularly in individuals with multiple risk factors, indicating a complex interplay between genetics and cholesterol levels in the disease's development.
Article Synopsis
- Birds infected with Reticuloendotheliosis virus (REV) experience immunosuppression, affecting their immune organs like the thymus, bursa of Fabricius, and spleen.
- The study investigates how the TLR-3/IFN-β pathway is disrupted in chickens by analyzing changes in immune response at various time points after infection.
- Results indicate that TLR-3, IRF-7, and NF-κB p65 levels change significantly during early REV infection, with a later decrease in NF-κB p65 correlating with reduced IFN-β levels, highlighting a complex interaction in the immune response.
Article Synopsis
- * The researchers used data from The Cancer Genome Atlas to identify eRNAs linked to disease-free survival and developed a risk score model to predict patient prognosis.
- * Key findings include a validated gene signature associated with eRNAs, insights into their influence on the tumor microenvironment, and variations in drug sensitivity based on patient risk levels.
Introduction: S100 calcium-binding protein A8 (S100A8) is also known as macrophage-related protein 8, which is involved in various pathological processes in the central nervous system post-traumatic brain injury (TBI), and plays a critical role in inducing inflammatory cytokines. Accumulating evidences have indicated that toll-like receptor 4 (TLR4) is considered to be involved in inflammatory responses post TBI. The present study was designed to analyze the hypothesis that S100A8 is the key molecule that induces inflammation TLR4 in TBI.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the role of BTBD7_hsa_circ_0000563, a circular RNA located on chromosome 14, in relation to atherosclerosis and identifies proteins regulated by its expression in coronary artery segments.
- Using RT-qPCR to measure expression levels and proteomic analysis to examine protein differences, the research found lower BTBD7_hsa_circ_0000563 levels in severely narrowed arteries and identified 49 proteins with significant expression changes correlated with its levels.
- The findings suggest that BTBD7_hsa_circ_0000563 may play a critical role in atherosclerotic changes, prompting the need for further studies to clarify its mechanisms and functions.
Article Synopsis
- The study investigates the connection between two SNPs (rs4977574 and rs1333045) on chromosome 9p21.3 and coronary artery disease (CHD) in a Chinese population.
- A total of 855 blood samples were analyzed using case-control methodology, revealing significant differences in allele frequencies between CHD patients and controls.
- Results suggest that the G allele of rs4977574 increases CHD risk, while the T allele of rs1333045 may lower it, with variations in serum apolipoprotein A levels linked to specific genotypes.
Article Synopsis
- Circular RNAs (circRNAs) are stable molecules that could serve as biomarkers and treatment targets for coronary artery disease due to their role in gene regulation.
- The study involved analyzing circRNAs from the coronary arteries of an 81-year-old man who died from a heart attack, revealing a total of 1,259 known and 381 new circRNAs through RNA sequencing.
- The research identified 66 circRNAs that were significantly regulated based on the presence of atherosclerosis, suggesting their potential involvement in the disease and their applicability in diagnostics or treatment.
To explore the association between methylation of antisense non-coding RNA in the INK4 locus (ANRIL) and coronary artery disease (CAD) development. Methylation levels of ANRIL in 100 subjects with CAD and 100 controls were quantitatively analyzed using Sequenom MassARRAY. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis was used to identify novel pathways.
View Article and Find Full Text PDFArticle Synopsis
- * Advances in synthetic biology offer innovative solutions for breaking down lignin and converting it into useful products like aromatic chemicals and bio-active substances.
- * Strategies include optimizing lignin-degrading enzymes, creating new conversion pathways, and enhancing the microorganisms used in the degradation process.
Article Synopsis
- Interleukin 17 (IL-17) is a cytokine that is elevated in glioma patients, but its specific effects on glioma cell growth and movement were not well understood before this study.
- The study found that IL-17 boosts both the growth and movement of glioma cells in laboratory settings and enhances tumor formation in mouse models.
- Mechanistically, IL-17 activates signaling pathways involving PI3K, Akt1, and NF-κB-p65, and inhibiting these pathways can reduce the stimulating effects of IL-17 on glioma cells.
: The aim of the present study is to investigate the association between the single nucleotide polymorphism (SNP) sites of peroxisome proliferator-activated receptor Δ (PPARD) and the risk of coronary artery disease (CAD). To this end, a prospective observational single-center study of the clinical data from 880 subjects in a Chinese population was conducted. : A total of 880 subjects, including 609 CAD patients and 271 control subjects, were selected for the present study.
View Article and Find Full Text PDFArticle Synopsis
- - Alzheimer’s disease (AD) is a slowly progressive neurodegenerative condition, and this study focuses on the potential of microRNA (miR-98) as a therapeutic approach to combat the disease by targeting certain proteins.
- - Researchers used 70 Kunming mice to examine how miR-98 influences amyloid β production, oxidative stress, and mitochondrial function through the Notch signaling pathway, specifically targeting a protein called HEY2.
- - The findings indicated that AD mice had low levels of miR-98 and high levels of HEY2, which were linked to poor cognitive abilities, increased oxidative stress, and neuronal damage, while miR-98 helped improve neuron survival and function.
Article Synopsis
- KLF16, a member of the Krüppel-like factor family, has been under-researched in gastric cancer (GC) despite its potential significance.
- The study found that KLF16 is highly expressed in GC tissues compared to normal tissues, correlating with aggressive tumor characteristics and poor patient prognosis.
- Knocking down KLF16 in GC cell lines reduced cell proliferation by altering key proteins, suggesting KLF16 could be a valuable target for new cancer therapies.
Article Synopsis
- The study compared gene expression in bladder tissues of cystitis glandularis (CG) patients to healthy controls, revealing 4,263 differentially expressed genes.* -
- Notably, specific genes like CCND1 and EGFR were found to be significantly upregulated in CG and bladder cancer (BC) patients, while TP53 showed decreased levels.* -
- The findings suggest a complex gene expression profile in CG patients that may aid in understanding CG and bladder cancer progression through identified signaling pathways and gene mechanisms.*
Article Synopsis
- - PACS (Picture Archiving and Communication System) is effectively used at Huzhou Central Hospital and works seamlessly with the hospital's HIS system through WEBSERVICE middleware.
- - The system complies with the DICOM 3.0 Standard, which is essential for medical imaging.
- - DICOM gateways are set up for non-DICOM devices, enabling the hospital to digitize all its imaging departments.
[The design and implementation of DICOM Server Mediate Layer].
Zhongguo Yi Liao Qi Xie Za Zhi
July 2002
Article Synopsis
- - A DICOM Server Mediate Layer is proposed in the paper to enhance communication with medical imaging devices following the DICOM3.0 standard.
- - It simplifies the interface between the DICOM server and other applications, making integration easier.
- - This solution facilitates the implementation of DICOM services, streamlining the process for developers working with medical applications.