Publications by authors named "Chen-Hong Tang"
Eight-stranded β-barrel outer membrane proteins can confer bacterial virulence via resistance to host innate defenses. This resistance function of OmpW, which was recently identified as an eight-stranded β-barrel protein, was investigated in this study. Our results demonstrated that upregulation of OmpW correlated with increased bacterial survival during phagocytosis.
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- Increasing evidence suggests that alternative splicing of glucocorticoid receptor (GR) transcripts contributes to glucocorticoid resistance, but the mechanisms behind it are unclear.
- The study investigates the roles of specific proteins (SR proteins and hnRNP A1) in the splicing of GR pre-mRNA using transfection assays in HeLa and 293T cells.
- Findings indicate that SRp40 can promote a shift from GRalpha to GRbeta splice variants in HeLa cells, but not in 293T cells, suggesting that SRp40's influence on GR splicing is cell-specific.