Structural isomerism engineering regulates molecular AIE behavior and application in visualizing endogenous hydrogen sulfide.

Hydrogen sulfide (HS) is a critical bioregulator implicated in numerous physiological and pathological processes, including cancer and neurodegenerative diseases. Compared with traditional instrument analysis, fluorescence detection technology based on small molecules in real-time and sensing HS has attracted attention. In this investigation, we developed a system of coumarin-based fluorophores linked with aminopyridine a dipolar imino-double bond.