Alkynyl Ligands Templated Assemblies of Silver Nanoclusters with Exceptional Electrochemiluminescence Activity for Pancreatic Cancer Specific tsRNAs Measurement.

Proper manipulation of the ligand complex on the motifs of metal nanoclusters (MNCs) to form an ordered self-assembly is an effective approach to enhance the electrochemiluminescence (ECL) emission of MNCs. We report a facile approach for the preparation of self-assembled AgNCs (AgNCs) induced by alkynyl ligands with enhanced ECL and stability. The formation of these AgNCs was simultaneously driven by the diverse coordination modes of alkynyl ligands with Ag and intercluster interactions, for which it was found that the para-substituted alkynyl ligands exhibited apparently irregular nanoparticles, while the monosubstituted counterparts were present in the form of ribbons.

The static and dynamic adsorptive performance of a nitrogen and sulfur functionalized 3D chitosan sponge for mercury and its machine learning evaluation.

The use of chitosan-based sponge materials for Hg(II) removal has gained attention recently due to their effectiveness. However, the complex preparation, limited performance, and poor acid resistance remained major drawbacks. Herein, a nitrogen‑sulfur functionalized macroporous chitosan sponge was successfully synthesized via two mild amidation reactions and exhibited abundant interconnected mesopores.

The MoS/rGO embed in macro-porous PAN gel as a novel DGT binding phase for the rapid and accurate detection of trace Hg(II).

The development of binding gels with a fast uptake rate, high capacity, and good selectivity could be beneficial for trace Hg(II) detection based on the DGT technology. In this study, a novel PAN@MoS/rGO-DGT was assembled by using the nanocomposite embedded in polyacrylonitrile membrane (PAN@MoS/rGO) as the binding phase. The interior regular finger-like macropore of the gel provided a convenient channel for the rapid mass diffusion of Hg(II), and the abundant sulfur offered the paramount driving force for trapping Hg(II).

An Efficient Bifunctional Core-Shell ZIF-90@ZIF-67 Composite as a Stable Pickering Interfacial Catalyst for the Deacetalization-Knoevenagel Tandem Reaction.

Exploiting advanced solid particles is crucial to the construction of Pickering emulsions catalysis. Recently, metal-organic frameworks (MOFs) have been used as ideal emulsifiers stabilizing Pickering emulsions for interfacial catalysis. Although Pickering emulsions stabilized by core-shell MOFs have significant importance in practical studies, to date there have been very limited reports on this topic.

Label-Free Raman Probing of the Intrinsic Electric Field for High-Efficiency Screening of Electricity-Producing Bacteria at the Single-Cell Level.

The fabrication of high-performance microbial fuel cells requires the evaluation of the activity of electrochemically active bacteria. However, this is challenging because of the time-consuming nature of biofilm formation and the invasive nature of labeling. To address this issue, we developed a fast, label-free, single-cell Raman spectroscopic method.

Chemical Pressure-Driven Band Convergence and Discordant Atoms Intensify Phonon Scattering Leading to High Thermoelectric Performance in SnTe.

SnTe is an intriguing alternative to PbTe for midtemperature thermoelectric applications. Despite steady progress, its performance is lagging, in part because of the large energy difference(Δ) between the light (L-band) and heavy (Σ-band) valence bands and higher lattice thermal conductivity (κ). Previous studies have shown that applying pressure can enhance the Seebeck coefficient () and power factor () of SnTe.

Experimental Study on Interfacial Shear Behavior of 3D Printed Recycled Mortar.

A novel shear test method on shear bond behavior of 3D printed interlayer interfaces and interstrip interfaces was proposed in this study. Thereafter, the effect of different replacement ratios of recycled sand, printing intervals, and surface treatments were investigated. The test results showed that under the same printing condition, the interfacial shear strengths of interlayer interface and interstrip interface were similar to each other.

TRIB3 knockdown increases the sensitivity of clear cell renal cell carcinoma to sunitinib by inducing ferroptosis.

Sunitinib resistance presents a significant challenge in the treatment of clear cell renal cell carcinoma (ccRCC). The role of TRIB3, a newly identified oncogene, in tumor drug resistance has been widely studied. However, the mechanism by which TRIB3 contributes to sunitinib resistance in ccRCC has not been previously explored.

Causal relationship between systemic circulatory inflammatory regulators and intervertebral disc degeneration: A bidirectional 2-sample Mendelian randomization study.

In the context of the development of intervertebral disc degeneration (IDD), inflammatory mediators play a pivotal role. Nevertheless, due to the influence of the inflammatory microenvironment, the causal relationship between specific inflammatory mediators and the development of IDD remains uncertain. The understanding of the causal relationship between inflammatory mediators and IDD is of great importance in preventing and delaying disc degeneration in the future.

Single-shot intensity diffraction tomography via polarization-multiplexed LED illumination.

We present a single-shot intensity diffraction tomography method via polarization-multiplexed LED illumination. Three LED elements covered with 0°, 45°, and 135° linear polarizers, respectively, are lit up simultaneously to illuminate the sample with illumination angles matching the numerical aperture of the objective. The scattering field of the sample is recorded on a single intensity image with a polarization sensor, and three intensity images corresponding to the three LED elements are decoupled from the intensity image by using a pre-calibrated intensity transform matrix.

Revealing the Mechanism of Esculin in Treating Renal Cell Carcinoma Based on Network Pharmacology and Experimental Validation.

Purpose: This study aims to explore the potential mechanisms of esculin in the treatment of renal cell carcinoma (RCC).

Methods: We employed network pharmacology to predict the potential mechanisms and targets of esculin in RCC. Molecular docking techniques were then employed to validate the predicted targets.

Contrasting Metallic (Rh) and Carbidic (2D-MoC MXene) Surfaces in Olefin Hydrogenation Provides Insights on the Origin of the Pairwise Hydrogen Addition.

Kinetic studies are vital for gathering mechanistic insights into heterogeneously catalyzed hydrogenation of unsaturated organic compounds (olefins), where the Horiuti-Polanyi mechanism is ubiquitous on metal catalysts. While this mechanism envisions nonpairwise H addition due to the rapid scrambling of surface hydride (H*) species, a pairwise H addition is experimentally encountered, rationalized here based on density functional theory (DFT) simulations for the ethene (CH) hydrogenation catalyzed by two-dimensional (2D) MXene MoC(0001) surface and compared to Rh(111) surface. Results show that ethyl (CH*) hydrogenation is the rate-determining step (RDS) on MoC(0001), yet CH* formation is the RDS on Rh(111), which features a higher reaction rate and contribution from pairwise H addition compared to 2D-MoC(0001).

How local electric field regulates C-C coupling at a single nanocavity in electrocatalytic CO reduction.

C-C coupling is of utmost importance in the electrocatalytic reduction of CO, as it governs the selectivity of diverse product formation. Nevertheless, the difficulties to directly observe C-C coupling pathways at a specific nanocavity hinder the advances in catalysts and electrolyzer design for efficient high-value hydrocarbon production. Here we develop a nano-confined Raman technology to elucidate the influence of the local electric field on the evolution of C-C coupling intermediates.

AUY922 improves sensitivity to sunitinib in clear cell renal cell carcinoma based on network pharmacology and in vitro experiments.

Clear Cell Renal Cell Carcinoma (ccRCC), the most prevalent form of renal cell carcinoma (RCC), poses a significant threat to human health due to its rising morbidity and mortality rates. Sunitinib, a pivotal targeted drug for the treatment of ccRCC, presents a significant challenge due to the high susceptibility of ccRCC to resistance. HSP90 inhibitor AUY922 has demonstrated anti-tumor activity in a range of cancer types.

Identification and experimental verification of immune-related hub genes in intervertebral disc degeneration.

Background: Inflammation and immune factors are the core of intervertebral disc degeneration (IDD), but the immune environment and epigenetic regulation process of IDD remain unclear. This study aims to identify immune-related diagnostic candidate genes for IDD, and search for potential pathogenesis and therapeutic targets for IDD.

Methods: Gene expression datasets were obtained from the Gene Expression Omnibus (GEO).

Participation of preovulatory follicles in the activation of primordial follicles in mouse ovaries.

The mechanisms behind the selection and initial recruitment of primordial follicles (PmFs) from the non-growing PmF pool during each estrous cycle in females remain largely unknown. This study demonstrates that PmFs closest to the ovulatory follicle are preferentially activated in mouse ovaries under physiological conditions. PmFs located within 40 μm of the ovulatory follicles were more likely to be activated compared to those situated further away during the peri-ovulation period.

Autoimmune encephalitis followed by hemophagocytic lymph histiocytosis: a case report.

Objective: This study aims to report three cases of autoimmune encephalitis followed by hemophagocytic lymphohistiocytosis.

Methods: Data of relevant patients treated between 2019 and 2022 were retrospectively collected from the Department of Neurology at the Second Affiliated Hospital of Guangzhou Medical University.

Results: The age at onset of the three patients was 37, 63, and 36 years, respectively.

Childhood exposure to polycyclic aromatic hydrocarbons is associated with emotional and behavioral problems in adolescence: a longitudinal study in China.

Purpose: The aim of this study was to investigate the relationship between childhood polycyclic aromatic hydrocarbon (PAH) exposure and emotional and behavioral problems in adolescence.

Methods: Participants included 998 school-age children aged 7-12 years (514 girls and 484 boys). Metabolite concentrations of four PAHs (1-hydroxypyrene [1-OHPyr], 2-hydroxynaphthalene [2-OHNap], 2-hydroxyfluorine [2-OHFlu], and 9-hydroxyphenanthrene [9-OHPhe]) were measured in urine samples at baseline (Dec 2014-Dec 2015).

Effective alleviation of depressive and anxious symptoms and sleep disorders in benzodiazepine-dependent patients through repetitive transcranial magnetic stimulation.

Benzodiazepine (BZD) dependence poses a significant challenge in mental health, prompting the exploration of treatments like repetitive transcranial magnetic stimulation (rTMS). This research aims to assess the impact of rTMS on alleviating symptoms of BZD dependence. A randomized control trial was employed to study 40 BZD-dependent inpatients.

Ecliptasaponin A protects heart against acute ischemia-induced myocardial injury by inhibition of the HMGB1/TLR4/NF-κB pathway.

Ethnopharmacological Relevance: Eclipta prostrata (Linn.) is a traditional medicinal Chinese herb that displays multiple biological activities, such as encompassing immunomodulatory, anti-inflammatory, anti-tumor, liver-protective, antioxidant, and lipid-lowering effects. Ecliptasaponin A (ESA), a pentacyclic triterpenoid saponin isolated from Eclipta prostrata (Linn.

Interplay of miRNAs and molecular pathways in spaceflight-induced depression: Insights from a rat model using simulated complex space environment.

Depression is a significant concern among astronauts, yet the molecular mechanisms underlying spaceflight-induced depression remain poorly understood. MicroRNAs (miRNAs) have emerged as potential regulators of neuropsychiatric disorders, including depression, but their specific role in space-induced depression remains unexplored. This study aimed to elucidate the involvement of candidate miRNAs (miR-455-3p, miR-206-3p, miR-132-3p, miR-16-5p, miR-124-3p, and miR-145-3p) and their interaction with differentially expressed genes (DEGs) in the neurobiology of spaceflight-induced depressive behavior.