Publications by authors named "Chen Zhuxiu"
Article Synopsis
- * A study on mice exposed to GenX showed significant changes in placental and offspring development, including altered body and placental weights and impaired placental structure from longer exposure to GenX.
- * The research revealed that subchronic exposure to GenX affected placental blood vessel formation and resulted in increased birth weights and premature puberty in offspring, suggesting potential health risks associated with GenX usage.
Article Synopsis
- * High doses of APAP (150 mg/kg/d) in pregnant mice led to low birth weight and disrupted vascular structures in the placenta, indicating its negative impact on placental angiogenesis.
- * The study found that APAP affects the signaling pathways in endothelial cells, specifically by increasing Suppressor of Cytokine Signaling 3 (SOCS3) levels, which disrupts crucial cellular functions needed for proper vessel formation.
As a broad-spectrum and efficient insecticide, beta-Cypermethrin (β-CYP) poses a health risk to pregnancy. It matters the mechanisms of maternal exposure to β-CYP for impacting reproductive health. The placenta, a transient organ pivotal for maternal-fetal communication during pregnancy, plays a crucial role in embryonic development.
View Article and Find Full Text PDFAdverse environmental factors during maternal gestation pose a threat to pregnancy. Environmental factors, particularly nanoparticles, can impact pregnancy by causing damage to the placenta. Compared to early gestation, foetuses in late gestation are more robustly developed and at lower risk of adverse effects from environmental factors.
View Article and Find Full Text PDFBackground: The biological effects of cerium dioxide nanoparticles (CeONPs), a novel material in the biomedical field, have attracted widespread attention. Our previous study confirmed that exposure to CeONPs during pregnancy led to abnormal trophoblast invasion during early placental development, thereby impairing placental development. The potential mechanisms may be related to low-quality decidualization triggered by CeONPs exposure, such as an imbalance in trophoblast invasion regulators secreted by decidual cells.
View Article and Find Full Text PDFThe primordial follicle pool established in early life determines the ovarian reserve in the female reproductive lifespan. Premature exhaustion of primordial follicles contributes to primary ovarian insufficiency (POI), that is dependent by the initial size of the primordial follicle pool and by the rate of its activation and depletion. AAI, a powerful nephrotoxin with carcinogenic potential, is present in the Aristolochiaceae species, which can release AAI into soil as a persistent pollutant.
View Article and Find Full Text PDFBackground: The increasing use of cerium dioxide nanoparticles (CeONPs) in biomedical field has attracted substantial attention about their potential risks to human health. Recent studies have shown that nanoparticles can induce placental dysfunction and even fetal abortion, but a more detailed mechanism of nanoparticles affecting placental development remains elusive.
Results: Here, we constructed a mouse exposure model with different doses of CeONPs (2.