Efficacy of ticagrelor and clopidogrel in treating unstable angina and their effects on serum inflammatory factors.

To evaluate the comparative efficacy of Ticagrelor and Clopidogrel in treating patients with coronary heart disease and unstable angina, as well as their effects on serum inflammatory factors, thereby providing a solid foundation for future clinical diagnosis and treatment. The frequency of angina attacks in the Ticagrelor group was lower than in the Clopidogrel group (P<0.05).

Genome-wide identification and analysis of phosphate utilization related genes (PURs) reveal their roles involved in low phosphate responses in Brassica napus L.

Background: Phosphorus (P) is an essential macronutrient for Brassica napus L. growth and development, and is mainly acquired from the soil as phosphate (Pi). However, there is no research on the system analysis of Pi utilization related genes (PURs) in B.

Supplementation of DHA enhances the cryopreservation of yak semen via alleviating oxidative stress and inhibiting apoptosis.

Introduction: Semen cryopreservation is a crucial method for preserving genetic resources and accelerating the breeding process in domestic animals. However, the frozen-thawed process often leads to physical and chemical damage in semen, resulting in oxidative stress that diminishes sperm vitality and fertilization potential. This study aimed to explore the effects of docosahexaenoic acid (DHA) on the quality of frozen-thawed yak semen.

Palmitic acid alters enhancers/super-enhancers near inflammatory and efferocytosis-associated genes in human monocytes.

Free fatty acids like palmitic acid (PA) are elevated in obesity and diabetes and dysregulate monocyte and macrophage functions, contributing to enhanced inflammation in these cardiometabolic diseases. Epigenetic mechanisms regulating enhancer functions play key roles in inflammatory gene expression, but their role in PA-induced monocyte/macrophage dysfunction is unknown. We found that PA treatment altered the epigenetic landscape of enhancers and super-enhancers (SEs) in human monocytes.

Iron-Cobalt Alloy@Graphene-Engineered Milk Extracellular Vesicles for Gastric Retentive Drug Delivery.

Oral drug delivery is widely used for treating gastric diseases as it allows drugs to act directly on gastric lesions, thereby improving therapeutic outcomes. However, its efficacy is hindered by the specific gastric environment, such as the gastric mucosal barrier, which limits drug penetration, and the short gastric emptying time, which results in transient residence time. Raw milk-derived extracellular vesicles (M-EVs) offer promise as a gastric drug delivery platform.

Biomechanical assessment of unilateral/bilateral lumbar spondylolysis with and without muscle weakness using finite element analysis.

Background: Spondylolysis is commonly linked to low back pain in athletes, and the connection between muscle weakness and spondylolysis is unclear. Therefore, this study examined the biomechanics of spondylolysis and influence of muscle weakness by finite element (FE) analysis.

Methods: A patient's L1-S1 lumbosacral unit was scanned by computed tomography, and generated a three-dimensional pathology-free FE model.

Ammonium bicarbonate buffer system for DNA hybridization and quantification by LC-ESI-MS/MS.

High salt buffer may be used for the UV/VIS or radiometric based detection of trihybrid DNA but would contaminate the electrospray mass spectrometer. Colorimetric DNA hybridization assays with the substrate BCIP/NBT reacted with the alkaline phosphatase-streptavidin (APSA) enzyme conjugate that showed a linear range for HIV DNA from 1 pM to 100 pM DNA in presence of high salt concentrations. Ammonia bicarbonate (AMBIC) or ethanolamine resulted in strong DNA hybridization similar to NaCl but was compatible with specific and sensitive mass spectrometry.

Polarity and fluorescent fractions of manure dissolved organic matter could affect differently the adsorption and desorption of antibiotics in soils.

The impacts of manure dissolved organic matter (DOM) on the adsorption and desorption of veterinary antibiotics in soils have not been fully explored. In this study, the effects of pig manure (PM) DOM and its hydrophilic and hydrophobic fractions on antibiotic adsorption and subsequent desorption in three topsoils of bamboo stands under different fertilization conditions (control, with heavy manure application, and with heavy manure application suspended) were examined by batch experiments, with the aid of excitation-emission matrix fluorescence spectroscopy, Fourier transformed infrared spectroscopy, and X-ray photoelectron spectroscopy. The addition of 100 mg-C L PM DOM was found to increase the adsorption (in terms of the Freundlich affinity coefficient (K)) of florfenicol by 71.

Discovery of a novel 2,4-thiazolidinedione derivative as dual inhibitor of β-catenin/TCF4 interaction and tubulin polymerization in colon cancer cells.

Hyperactivation of the Wnt/β-catenin signaling pathway has been widely recognized as a pathogenic mechanism for colorectal cancer (CRC). Based on a previously reported lead compound, iCRT14, a series of 2,4-thiazolidinedione derivatives were designed, synthesized, and evaluated in vitro for their antiproliferative activity against colon cancer cells. Compound 15k exhibited the most potent activity against the HCT116 and SW480 cell lines.

Highly Reusable Enzyme-Driven DNA Logic Circuits.

In recent years, DNA has emerged as a promising molecule for the construction of molecular computing systems. In the research field of DNA logic circuits, enzyme-driven DNA logic circuits, which offer faster reactions and lower complexity, have become the key focus in the field. However, it remains a significant drawback that it lacks the capability of being reused.

gma-miR828a Negatively Regulates Resistance to Tea Leaf Spot Caused by Lasiodiplodia theobromae Through Targeting the CsMYB28-CsRPP13 Module.

Leaf spot caused by the fungus Lasiodiplodia theobromae severely affects the quality and production of tea (Camellia sinensis) in plantations across southwestern China. Currently, no effective control measures are available, and the damage to tea leaves is also exacerbated by a lack of understanding regarding the epidemiology of the disease. Previous studies have suggested that gma-miR828a is differentially expressed during L.

Impact of pilot public hospital reform on efficiencies: a DEA analysis of county hospitals in East China, 2009-2015.

Background: China started a pilot public hospital reform in 2012 to improve governance and efficiency in healthcare services delivery among county-level hospitals. This study aims to investigate the impact of the pilot reform on hospital efficiency and productivity by using a unique dataset of county hospitals in East China during 2009-2015.

Methods: A three-stage approach is used.

DARCS: Memory-Efficient Deep Compressed Sensing Reconstruction for Acceleration of 3D Whole-Heart Coronary MR Angiography.

Three-dimensional coronary magnetic resonance angiography (CMRA) requires reconstruction algorithms that can significantly suppress the artifacts encountered in heavily undersampled acquisitions. While unrolling-based deep reconstruction methods have achieved state-of-the-art performance on 2D image reconstruction, their application in 3D reconstruction is hindered by the large amount of memory required to train an unrolled network. In this study, we propose a memoryefficient deep compressed sensing method that employs a sparsifying transform based on a pre-trained artifact estimation network.

EvaSurf: Efficient View-Aware Implicit Textured Surface Reconstruction.

Reconstructing real-world 3D objects has numerous applications in computer vision, such as virtual reality, video games, and animations. Ideally, 3D reconstruction methods should generate high-fidelity results with 3D consistency in real-time. Traditional methods match pixels between images using photo-consistency constraints or learned features, while differentiable rendering methods like Neural Radiance Fields (NeRF) use differentiable volume rendering or surface-based representation to generate high-fidelity scenes.

RSB-Pose: Robust Short-Baseline Binocular 3D Human Pose Estimation with Occlusion Handling.

In the domain of 3D Human Pose Estimation, which finds widespread daily applications, the requirement for convenient acquisition equipment continues to grow. To satisfy this demand, we focus on a short-baseline binocular setup that offers both portability and a geometric measurement capability that significantly reduces depth ambiguity. However, as the binocular baseline shortens, two serious challenges emerge: first, the robustness of 3D reconstruction against 2D errors deteriorates; second, occlusion reoccurs frequently due to the limited visual differences between two views.

Cephalometric analyses of the correlation between nasal and maxilla morphology among adult patients with cleft.

Objective: To explore if the nasal profile is influenced by maxillary hypoplasia among patients with congenital cleft lip and palate.

Methods: Young adult patients with cleft and noncleft controls were enrolled. Nasal and maxillary profiles were measured on lateral cephalometric radiographs.

Design, synthesis and optimization of Apcin analogues as Cdc20 inhibitors for triple-negative breast cancer therapy.

Cell division cycle 20 homologue (Cdc20) is an essential mitotic regulator whose overexpression is closely associated with tumorigenesis and poor prognosis in triple-negative breast cancer (TNBC). Targeting Cdc20 has therefore emerged as a promising therapeutic avenue for this aggressive malignancy. In the present study, a receptor-based drug design approach was employed to optimize Apcin analogues as Cdc20 inhibitors.

International REACH forgiveness intervention: a multisite randomised controlled trial.

Objectives: To determine whether a brief self-directed forgiveness workbook intervention could alter forgiveness, depression symptoms, and anxiety symptoms.

Design: A multisite randomised waitlist-controlled trial was conducted among 4598 participants. Recruitment occurred from 11 February 2020 to 30 September 2021.

Portrait of municipal wastewater of China: Inspirations for wastewater collection, treatment and management.

Over the past decades, significant importance has been attached to municipal wastewater treatment in China. But wastewater treatment plants (WWTPs) still grapple with operation inefficiencies due to low influent concentrations. This study comprehensively provides a portrait of Chinese municipal wastewater from the national and province levels, drawing on official data available.

Micro-Vibration Control of Deployable Space Optical Imaging System Using Distributed Active Vibration Absorbers.

This paper presents a distributed vibration control method using attachable absorbers for micro-vibration control of large space payload structures. The distributed vibration control system is modeled at three levels. The simplification of the attachable absorber model is discussed, and the single-channel ANC controller is extended to a multi-channel configuration.

Plants' Overexpression of the MYB Transcription Factor in the Face of Stress Hazards Enhances Salt and Cold Tolerance.

'Beta' ( × ) is a vine fruit tree of the genus Vitis which is a cross between American and riparian grapes. In the current situation of grape production in northern regions, cold, drought, and salinity are important bottlenecks restricting its development, while some grape rootstocks with excellent traits show the disadvantage of poor resilience. 'Beta' ( × ), one of the most extensively utilized rootstocks in viticulture, has demonstrated remarkable resilience to adverse conditions.

Implications of tissue specific STING protein flux and abundance on inflammation and the development of targeted therapeutics.

Drugs targeting the ER-resident innate immune receptor Stimulator of Interferon Genes (STING) are in development for treatments of cancer and inflammatory diseases. Accurate determination of STING receptor levels in normal and disease tissue is an essential component of modeling pharmacology and drug-target disposition. Using metabolic labeling with deuterium oxide paired with high resolution mass spectrometry, we report the protein fractional synthesis rates and turnover of STING in wild-type (C57BL/6) and inflamed mice carrying the Trex1 D18N mutation (Trex1D18N) as a STING-dependent model of human Acardi-Goutiéres syndrome.

Biological functions of 5-methylcytosine RNA-binding proteins and their potential mechanisms in human cancers.

The 5-methylcytosine (m5C) modification is a crucial epigenetic RNA modification, which is involved in the post-transcriptional regulation of genes. It plays an important role in various biological processes, including cell metabolism, growth, apoptosis, and tumorigenesis. By affecting the proliferation, migration, invasion, and drug sensitivity of tumor cells, m5C methylation modification plays a vital part in the initiation and progression of tumors and is closely associated with the poor tumor prognosis.

Practical ppb-Level Room Temperature Chemiresistive Nitric Oxide Sensing Assembly Based on Ultrathin Thick Porphyrin MOF Nanosheets.

Nitric oxide is an endogenous biological signaling molecule, and the corresponding fractional exhaled NO serves as an important indicator in clinical diagnostics and therapeutic applications. However, achieving accurate and rapid monitoring of ppb-level fractional exhaled nitric oxide (FeNO) at room temperature remains a significant challenge. Herein, ultrathin porphyrin metal-organic framework (MOF) sheets are selected to assemble with supramolecularly functionalized graphene sheets through hydrogen bonding and electrostatic interaction with 6 nm thickness.

Ruditapes philippinarum Polysaccharide Alleviates Hyperglycemia by Modulating Gut Microbiota in a Mouse Model of Type 2 Diabetes Mellitus.

Type 2 diabetes mellitus (T2DM), a widespread chronic metabolic disorder, presents a global challenge. Metformin hydrochloride, although widely prescribed, is associated with notable side effects. This study aims to explore safer, more effective alternatives by assessing the impact of Ruditapes philippinarum polysaccharides (RPPs) on glycemic control and modulation of microbiota in T2DM mice.