Designing of a wide-area power system stabilizer using an exponential distribution optimizer and fuzzy controller considering time delays.

In this paper, explore the effectiveness of a new Wide Area Fuzzy Power System Stabilizer (WAFPSS), optimized using the Exponential Distribution Optimization (EDO) algorithm, and applied to an IEEE three-area, six-machine power system model. This research primarily focuses on assessing the stabilizer's capability to dampen inter-area oscillations, a critical challenge in power grid operations. Through extensive simulations, the study demonstrates how the WAFPSS enhances stability and reliability under a variety of operational conditions characterized by different communication delay patterns.

Microplastics in the surface waters of the northern South China Sea: Interannual variation and potential ecological risks.

Microplastic pollution in marine environments has become a global concern due to its potential ecological risks. However, long-term data on microplastic distribution are scare, hindering the assessment of the ecological threats. This study monitored microplastics pollution in the surface water of the northern South China Sea from 2019 to 2023.

Application value of CT three-dimensional reconstruction technology in the identification of benign and malignant lung nodules and the characteristics of nodule distribution.

Objective: The study aimed to evaluate the application value of computed tomography (CT) three-dimensional (3D) reconstruction technology in identifying benign and malignant lung nodules and characterizing the distribution of the nodules.

Methods: CT 3D reconstruction was performed for lung nodules. Pathological results were used as the gold standard to compare the detection rates of various lung nodule signs between conventional chest CT scanning and CT 3D reconstruction techniques.

Genetic prediction of blood metabolites mediating the relationship between gut microbiota and postpartum depression: A mendelian randomization study.

Background: Observational studies have suggested an association between gut microbiota(GM) and postpartum depression (PPD). However, the causal relationship remains unclear, and the role of blood metabolites in this association remains elusive.

Methods: This study firstly elucidated the causal relationship among 196 GM taxa, 224 blood metabolites, and PPD from a genetic perspective, employing two-sample Mendelian randomization (MR).

Comparison of using animal manure and sludge compost as biofilter filling material for off-gas control in aerobic composting.

Biofiltration is an important method for composting off-gas treatment. Compost-based materials are widely used as the filling media for biofilter. To expand the application of compost from different composting materials in off-gas control for organic waste aerobic composting, the NH removal efficiency, NO generation, and microbial communities of ammonia monooxygenase (amoA functional gene was selected) and nitrite reductase (nirS functional gene was selected) were investigated using the animal manure compost (AMC) and sludge compost (SC) as filling materials.

Off-pump coronary artery bypass grafting versus percutaneous coronary intervention with second-generation drug-eluting stents for coronary artery revascularization.

Objective: This study compared the clinical efficacy of off-pump coronary artery bypass grafting (OPCAB) with percutaneous coronary intervention (PCI) in the treatment of left main coronary artery and/or triple-vessel disease (LM and/or TVD).

Methods: We retrospectively enrolled 1484 consecutive patients with LM and/or TVD in Shanxi Cardiovascular Hospital from January 2015 to December 2022 and divided them into the OPCAB group (n = 583) and the PCI group (with second-generation drug-eluting stents) (n = 901). Propensity score matching was used for 316 equally matched pairs of patients in the groups.

Multibranch semantic image segmentation model based on edge optimization and category perception.

In semantic image segmentation tasks, most methods fail to fully use the characteristics of different scales and levels but rather directly perform upsampling. This may cause some effective information to be mistaken for redundant information and discarded, which in turn causes object segmentation confusion. As a convolutional layer deepens, the loss of spatial detail information makes the segmentation effect achieved at the object boundary insufficiently accurate.

Clinical characteristics and prediction model of re-positive nucleic acid tests among Omicron infections by machine learning: a real-world study of 35,488 cases.

Background: During the Omicron BA.2 variant outbreak in Shanghai, China, from April to May 2022, PCR nucleic acid test re-positivity (TR) occurred frequently, yet the risk factors and predictive models for TR remain unclear. This study aims to identify the factors influencing Omicron TR and to develop machine learning models to predict TR risk.

Sex modifies association between dietary sodium intake and cardiovascular disease mortality among US adult with hypertension: a national population-based cohort.

Objectives: The objective of this study was to examine the relationship between dietary sodium intake and cardiovascular disease (CVD) mortality in hypertensive American adults.

Methods: A prospective cohort study was conducted to examine the association between dietary sodium intake, as estimated by a single 24-h dietary recall from the National Health and Nutrition Examination Survey (2003-2012), and mortality data obtained from the National Death Index.

Results: This study included 12,236 adults with hypertension, with 837 CVD-related deaths identified over a median follow-up period of 10.

ROS Responsive Cerium Oxide Biomimetic Nanoparticles Alleviates Calcium Oxalate Crystals Induced Kidney Injury via Suppressing Oxidative Stress and M1 Macrophage Polarization.

Emerging studies have demonstrated that M1 macrophage polarization and oxidative stress play important roles in calcium oxalate (CaOx) induced kidney injury, which leads to increased crystals deposition. ROS scavenging nanozymes and kidney-targeted nanoparticles for antioxidant drugs delivery have emerged as an arisen methodology for kidney injury therapy. However, cell membrane biomimetic-modified nanozymes as anti-inflammatory drug delivery systems for the treatment of kidney injury is rarely reported.

Glycogen-accumulating organisms promote phosphate recovery from wastewater by pilot-scale biofilm sequencing batch reactor: Performance and mechanism.

A high phosphate (P) recovery concentration was achieved in pilot-scale biofilm sequencing batch reactor (BSBR) with a low carbon source (C) cost. Especially, a high-abundance glycogen-accumulating organisms (GAOs) (13.93-31.

Real-time diagnosis of sampled lesions in targeted biopsy of prostate Cancer using a novel tracer [Cu] Cu-DOTA-PSMA-3Q: a pilot preclinical study.

Purpose: Prostate-specific membrane antigen positron emission tomography (PSMA-PET) guided targeted biopsy has shown potential for detecting more prostate cancer (PCa) cases. However, relying exclusively on imaging may risk missing lesions, an issue that could be addressed by incorporating radiation-guided technology. Accordingly, we aimed to develop a novel PSMA radiotracer with a long half-life, [Cu]Cu-DOTA-PSMA-3Q, and evaluate its targeting accuracy.

N6-methyladenosine RNA modification promotes Severe Fever with Thrombocytopenia Syndrome Virus infection.

Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV), a novel bunyavirus primarily transmitted by Haemaphysalis longicornis, induces severe disease with a high mortality rate. N6-methyladenosine (m6A) is a prevalent internal chemical modification in eukaryotic mRNA that has been reported to regulate viral infection. However, the role of m6A modification during SFTSV infection remains elusive.

Construction of a 2.5D Deep Learning Model for Predicting Early Postoperative Recurrence of Hepatocellular Carcinoma Using Multi-View and Multi-Phase CT Images.

Purpose: To construct a 2.5-dimensional (2.5D) CT radiomics-based deep learning (DL) model to predict early postoperative recurrence of hepatocellular carcinoma (HCC).

Intrauterine inoculation of pseudorabies virus impairs mouse embryo implantation via inducing inflammation and apoptosis in endometrium.

Pseudorabies virus (PRV) is the pathogenic agent of pseudorabies, causing serious reproductive failure in swine. However, it is still unknown whether PRV uterine inoculation impairs blastocyst implantation. In the present study, a PRV infection mouse model was developed.

Association between hemoglobin-to-red blood cell distribution width ratio and chronic kidney disease: A cross sectional study.

The hemoglobin-to-red blood cell distribution width ratio (HRR) is recognized as a novel prognostic biomarker; however, studies exploring its relationship with chronic kidney disease (CKD) are scarce. This study used data from the National Health and National Health and Nutrition Examination Survey database from 2005 to 2018. The analysis included individuals aged ≥ 20 years who had complete HRR and CKD data.

Yi-Fei-San-Jie Chinese medicine formula reverses immune escape by regulating deoxycholic acid metabolism to inhibit TGR5/STAT3/PD-L1 axis in lung cancer.

Background: Yi-Fei-San-Jie Formula (YFSJF), a proprietary medicine of the First Affiliated Hospital of Guangzhou University of Chinese Medicine, has been widely used in clinical practice for several years and is currently being tested in randomized controlled trials for early-stage lung cancer in China. However, the mechanisms by which YFSJF affects lung cancer biology, particularly the immune microenvironment and metabolic processes, remain poorly understood.

Purpose: This study aims to explore how YFSJF modulates the immune microenvironment and metabolism in lung cancer, specifically its unique role in inhibiting immune evasion by targeting the TGR5/STAT3/PD-L1 pathway, which has not previously been reported.

Development of imaged capillary isoelectric focusing as a platform mispairing byproduct testing method for asymmetric WuXiBody-based bispecific antibodies.

This study explores the application of imaged capillary isoelectric focusing (icIEF) to distinguish and quantify mispairing byproducts in asymmetric WuXiBody-based bispecific antibodies (AsWXbsAbs). Bispecific antibody (BsAb), developed using Knobs-into-Holes (KiH) technology, often result in byproducts such as knob-knob (KK) and hole-hole (HH) homodimers, which share similar sizes with the target BsAb, complicating their separation by traditional methods like size exclusion chromatography-high performance liquid chromatography (SEC-HPLC). Our approach leverages the unique pI differences introduced by substituting the CH1/CL domain with the T cell receptor (TCR) constant domain in AsWXbsAbs.

Transcriptome analysis uncovers the expression of genes associated with growth in the gills and muscles of white shrimp (Litopenaeus vannamei) with different growth rates.

Litopenaeus vannamei is a crucial species in aquaculture. The gene expression patterns associated with distinct growth rates are not well understood. To investigate this, we used RNA-seq to study the underlying growth mechanism of L.

SNAP25-induced MYC upregulation promotes high-grade neuroendocrine lung carcinoma progression.

Background: This study investigated the expression and role of Synaptosome associated protein 25 (SNAP25) in high-grade neuroendocrine carcinoma (HGNEC).

Methods: We used differentially expressed analysis and weighted gene co-expression network analysis (WGCNA) to identify key genes and modules in HGNEC. KEGG and GO analyses helped understand these genes' roles, and ROC curves assessed their diagnostic value.

Enhanced recovery after surgery in thulium laser prostatectomy: benefits and complication risk factors.

Objective: To investigate the application of Enhanced Recovery After Surgery (ERAS) in the nursing care of patients undergoing Thulium laser prostatectomy and analyze the factors affecting postoperative complications.

Methods: This retrospective study analyzed the clinical data of 108 patients who underwent Thulium Laser Prostatectomy in the Zhejiang University Sir Run Run Shaw Alaer Hospital from July 2022 to October 2023. Among them, 58 patients who received nursing care based on the concept of ERAS from January 2023 to October 2023 were assigned to the study group, while the other 50 patients who received conventional nursing care from July 2022 to December 2022 were assigned to the control group.

Increases in 4-Acetaminobutyric Acid Generated by Phosphomevalonate Kinase Suppress CD8 T Cell Activation and Allow Tumor Immune Escape.

Certain metabolites in the tumor microenvironment (TME) can alter innate immunity. Here, it is shown how phosphomevalonate kinase (PMVK) allows hepatocellular carcinoma (HCC) cells to overcome the anti-tumor immunity mediated by CD8 T cells. In HCCs, depletion of PMVK is required to facilitate CD8 T cell activation and their subsequent suppression of tumor growth.