Publications by authors named "Chen Zhi-bin"

Background: Acute type A aortic dissection (TAAD) is a life-threatening cardiovascular emergency with a high mortality rate. The peri-operative factors influencing in-hospital mortality among surgically treated TAAD patients remain unclear. This study aimed to identify key peri-operative risk factors associated with in-hospital mortality.

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Chronic tinnitus is a central nervous system disorder. Currently, the effects of gut microbiota on tinnitus remain unexplored. To explore the connection between gut microbiota and tinnitus, we conducted 16S rRNA sequencing of fecal microbiota and serum metabolomic analysis in a cohort of 70 patients with tinnitus and 30 healthy volunteers.

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  • Computed tomographic perfusion (CTP) can enhance the diagnosis of asymptomatic intracranial arterial stenosis by improving accuracy and reducing interpretation time when used alongside computed tomographic angiography (CTA).
  • A study reviewed 39 patients who underwent CTP, CTA, and digital subtraction angiography (DSA), finding that adding CTP images significantly increased diagnostic accuracy for various arteries.
  • Results indicated that the mean interpretation time decreased notably when combining CTP with CTA images, suggesting CTP is beneficial for evaluating patients with asymptomatic intracranial arterial stenosis.
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Objective: Gastric cancer (GC) ranks fifth in incidence and fourth for mortality worldwide. The response to immune checkpoint blockade (ICB) therapy in GC is heterogeneous due to tumour-intrinsic and acquired immunotherapy resistance. We developed an immunophenotype-based subtyping of human GC based on immune cells infiltration to develop a novel treatment option.

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Background: IgG4-related disease (IgG4-RD) is a newly discovered systemic disease that can affect any organ or tissue in the body. IgG4-related kidney disease (IgG4-RKD) is relatively rare but essential to IgG4-RD. However, there are few reports of IgG4-RD mimicking malignant ureteral tumors leading to hydronephrosis.

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Chronic obstructive pulmonary disease (COPD) is a common chronic pulmonary disease with multiple etiologies and pathological changes. PYK2 expression is significantly increased in lipopolysaccharide-induced lung injury, but it mediates chronic lung inflammation. The mechanism of its occurrence remains unclear.

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  • * The study involved 36 male rats split into six groups, with different treatments including castration and testosterone injections. Key measurements included intracavernous pressure, testosterone and nitric oxide levels, and markers associated with pyroptosis and collagen production.
  • * Results showed decreased erectile function and significant increases in pyroptotic markers in the castration groups, suggesting low androgen levels lead to ED by triggering pyroptosis in the smooth muscle and endothelial cells of the
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Objective: To investigate the biomechanical effects of different insertion angles of absorbable screws for the fixation of radial head fractures.

Methods: The finite element models used to simulate the fractures were created based on CT scans. Two absorbable screws were used to fix and maintain the stability of the fracture, and the angles between the screws were set to 0°, 15°, 30°, 45°, 60°, 75°, and 90°.

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Objectives: To investigate whether the levels of serum C-reactive protein (CRP), salivary interleukin (IL)-6 and IL-lβ in metabolic syndrome (MS) patients can be potential monitors for inflammation in MS patients with severe periodontitis.

Methods: A total of 114 MS patients and 49 systemically healthy subjects were enrolled. CRP in serum and IL-1β and IL-6 in non-stimulated whole saliva were collected from these patients and subjects and analysed by enzyme-linked immunosorbent assay (ELISA).

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We have explored the method of extraction and purification of cyclic-peptide extract (CPE) from (Miq.) Pax. (Taizishen, TZS), characterized the structure about cyclic-peptide compounds and investigated the biological activity of CPE attenuating chronic obstructive pulmonary disease (COPD) in rats.

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  • The study investigated how the placement depth of dental implants affects microbial colonization in inflamed sites using dogs as subjects.
  • Four types of implants were tested based on their placement: two screwed-in (SI) and two tapped-in (TI), with varying depths (crestally vs. subcrestally).
  • Results showed an increase in periodontal pathogens, particularly T. forsythia, at deeper placements, suggesting that subcrestal implants might lead to higher levels of infection during early peri-implantitis stages.*
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Atrial myxoma is the most common type of primary cardiac tumor and it is closely associated with stroke in adults. Early diagnosis and treatment of atrial myxomas is essential for the prevention of embolic events. The aim of the present study was to assess neurological complications associated with atrial myxoma.

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Objectives: To investigate the application of the microsurgical treatment in nasal skull-base tumors resection.

Methods: In a retrospective study, totally 15 cases with tumors in the nasal skull-base received microsurgical-assisted treatment in our department from February 2012 to June 2017 were analysed. Lateral rhinotomy approach was carried out in 11 patients and posterior wall of the maxillary sinus approach in 4 patients.

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Objectives: To investigate the clinical and pathological features of patients with unilateral sinonasal disease (USD).

Methods: A retrospective analysis was completed on 376 adult patients with USD from January 2015 to December 2016. Their presenting symptoms, nasal endoscope, CT scanning, and pathology were analyzed respectively.

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  • Macrophage polarization can adapt based on various signaling pathways and transcription factors, with SOCS acting as a crucial inhibitor in immune responses.
  • Transfection of SOCS1 shRNA in mouse macrophages led to increased levels of JAK1 and STAT1, suggesting enhanced signaling through the JAK1/STAT1 pathway.
  • Fludarabine treatment affected the expression of pro-inflammatory cytokines, altering M1 and M2 macrophage polarization dynamics, indicating the complex interplay between SOCS1 and macrophage activation.
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Sepsis is one of the most challenging health problems worldwide. Our previous study showed that chronic schistosoma japonica (SJ) infection might increase serum anti-inflammatory factors to play a protective role, thus improving the survival rate of septic mice. Further research revealed that SJ infection promoted J774A.

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In the present study we investigated the effects of different durations of using high-heeled shoes on plantar pressure and gait. A questionnaire survey and dynamic plantar pressure measurements were performed in 20 control females and 117 females who had worn high-heeled shoes for a long time. According to the duration of using high-heeled shoes (as specified in the questionnaire), subjects were divided into a control group and five groups with different durations of use (i.

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  • The study aimed to examine how osteoprotegerin (OPG) impacts the activity of a specific type of bone cell, known as cementoblasts, using a mouse cell line in a lab setting.
  • Researchers used various techniques, including cell transfection and assays, to confirm that OPG was successfully introduced into the cells and to measure any changes in cell growth and gene expression.
  • Results showed that increasing OPG levels led to a greater proliferation rate of the cementoblasts and enhanced expression of key genes and proteins associated with bone formation, indicating that OPG boosts cementoblast activity.
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  • *The study found that a specific protein from Trichinella spiralis, called rTsP53, has anti-inflammatory effects that can protect mice from a model of sepsis induced by LPS.
  • *rTsP53 treatment lowered harmful inflammatory cytokines and promoted the activation of M2 macrophages, suggesting it helps modulate the immune response to prevent severe sepsis.
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Objective: To investigate the potential association between FADS1 rs174537 polymorphism and serum proteins in patients with aggressive periodontitis, which may provide benefits for diagnosis and treatment of aggressive periodontitis.

Methods: A total of 353 patients with aggressive periodontitis (group AgP) and 125 matched controls (group HP) were recruited in the study. Genotyping of FADS1 rs174537 and serum biochemical indexes were tested at the study's start.

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Objective: To analyze the serum IgG titers to Aggregatibacter actinomycetemcomitans(Aa) and associated factors in patients with aggressive periodontitis (AgP).

Methods: Venous blood samples were collected from 62 AgP patients and 45 periodontal healthy controls, unstimulated whole saliva and pooled subgingival plaque samples of AgP patients were also collected for the detection of Aa (PCR method). Serum IgG titers to Aa serotype c were measured by enzyme-linked immunosorbnent assay (ELISA).

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Porphyromonas gingivalis causes inflammation, and leads to the periodontitis in gingival tissue damage and bone resorption. Epigallocatechin-3-gallate (EGCG) is a major polyphenol extract from green tea with plenty of pharmacological functions. The aim of this study was to determine whether continuous oral intake of EGCG would alleviate P.

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  • Micrometam C is a new marine compound derived from the mangrove plant Micromelum falcatum, which was studied for its anti-inflammatory effects.
  • It showed a significant reduction in immune cell migration during inflammation in genetically modified zebrafish and decreased harmful reactive oxygen species (ROS) in both zebrafish and macrophage cells.
  • The compound also helped restore key antioxidant levels and inhibited specific inflammatory pathways, suggesting that its protective effects are largely due to its antioxidant properties.
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Objective: To investigate the relationship between vitamin D receptor (VDR) gene polymorphisms and chronic periodontitis(CP).

Methods: Buccal swabs from 105 patients with mild/mode-rate CP and 85 severe CP were collected, DNA was extracted from these buccal swabs using the TIANamp Swab DNA Kit [TIANGEN Biotech (Beijing) CO.Ltd].

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  • This study aimed to explore how simvastatin affects the expression of iNOS and BDNF in the substantia nigra of rats with Parkinson disease induced by LPS.
  • The research found that LPS exposure led to typical Parkinsonian symptoms, loss of dopamine neurons, increased inflammatory markers, and reduced BDNF levels, but simvastatin treatment countered these changes.
  • The conclusion suggests that simvastatin may protect dopaminergic neurons by enhancing repair processes and reducing oxidative stress, ultimately improving brain function in the context of Parkinson's disease.
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