Design of Double Strains in Triboelectric Nanogenerators toward Improving Human Behavior Monitoring.

Triboelectric nanogenerators (TENGs) offer a convenient means to convert mechanical energy from human movement into electricity, exhibiting the application prospects in human behavior monitoring. Nevertheless, the present methods to improve the device monitoring effect are limited to the design of a triboelectric material level (control of electron gain and loss ability). As compared with reported work, we improve the monitoring effect of TENG-based tactile sensors by optimizing the structure of the electrode/triboelectric material interface by means of a multiple strains mechanism.

Identification of disulfidptosis-related subtypes in gastric cancer and GAMT is a key gene during disulfidptosis.

Recent studies have found that disulfidptosis occurs in cells under glucose starvation. The role of this programmed death method in gastric cancer remains to be explored. Cluster analysis based on disulfidptosis related genes to analyze the differential characteristics of disulfidptosis subtypes.

A novel approach for agricultural carbon emission reduction by integrating fermatean neutrosophic set with WINGS and AHP-EWM.

Agriculture is a major contributor to global greenhouse gas emissions, highlighting the urgent need for effective carbon reduction strategies. This study presents an innovative integrated model that employs Fermatean Neutrosophic Set in conjunction with the Weighted Influence Nonlinear Gauge System and the Analytic Hierarchy Process combined with the Entropy Weight Method to assess key factors influencing agricultural carbon reduction. Our study delineates the hierarchical importance of factors influencing carbon emissions, with carbon emission reduction policy (τ4) emerging as the paramount factor, attributed a value of 0.

ALKBH5 acts a tumor-suppressive biomarker and is associated with immunotherapy response in hepatocellular carcinoma.

As immune-checkpoint inhibitors (ICIs) therapy has made great strides in hepatocellular carcinoma (HCC) treatment, improving patient response to this strategy has become the main focus of research. Accumulating evidence has shown that mA methylation plays a crucial role in the tumorigenesis and progression of HCC, while the precise impact of the mA demethylase ALKBH5 on the tumor immune microenvironment (TIME) of HCC remains poorly defined. The clinical significance of ALKBH5 and TIM3 were evaluated in human HCC tissues.

Endowing single-crystal polymers with circularly polarized luminescence.

The preparation of single-crystal polymers with circularly polarized luminesce (CPL) remains a challenging task in chemistry and materials science. Herein, we present the single-crystal-to-single-crystal topochemical photopolymerization of a chiral organic salt to achieve this goal. The in-situ reaction of 1,4-bis((E)-2-(pyridin-4-yl)vinyl)benzene (1) with chiral (+)- or (-)-camphorsulfonic acid (CSA) gives the monomer crystal 1[( + )/( - )-CSA] showing yellow CPL with a high luminescent dissymmetry factor |g| of 0.

HDAC6 deacetylates TRIM56 to negatively regulate cGAS-STING-mediated type I interferon responses.

Histone deacetylase HDAC6 has been implicated in regulating antiviral innate immunity. However, its precise function in response to DNA virus infection remains elusive. Herein, we find that HDAC6 deficiency promotes the activation of cGAS-STING signaling and type I interferon (IFN) production, both in vitro and in vivo, resulting in a decrease in HSV-1 infection.

Subtilisin-like protease 4 regulates cold tolerance through cell wall modification in rice.

Rice is susceptible to cold temperatures, especially during the seedling stage. Despite extensive research into the cold tolerance mechanisms of rice, the number of cloned genes remains limited. Plant subtilisin-like proteases (SUBs or SBTs) are protein-hydrolyzing enzymes which play important roles in various aspects of plant growth as well as the plant response to biotic and abiotic stress.

A bi-level optimization strategy of electricity-hydrogen-carbon integrated energy system considering photovoltaic and wind power uncertainty and demand response.

To address the power supply-demand imbalance caused by the uncertainty in wind turbine and photovoltaic power generation in the regional integrated energy system, this study proposes a bi-level optimization strategy that considers the uncertainties in photovoltaic and wind turbine power generation as well as demand response. The upper-level model analyzes these uncertainties by modeling short-term and long-term output errors using robust optimization theory, applies an improved stepwise carbon trading model to control carbon emissions, and finally constructs an electricity-hydrogen-carbon cooperative scheduling optimization model to reduce wind and carbon emissions. The lower-level model incentivizes users to participate in integrated demand response through dynamic energy pricing, thereby reducing the annual consumption cost of load aggregator.

Exosomes derived from hUC-MSCs exhibit ameliorative efficacy upon previous cesarean scar defect via orchestrating β-TrCP/CHK1 axis.

Previous cesarean scar defect (PCSD), also acknowledged as the myometrium of uterus defects, which commonly results in myometrial discontinuity between the uterine and cervical cavity. Current literatures have indicated the efficacy of MSCs and MSC-derived exosomes (MSC-Exos) for diverse refractory disease administration, yet the feasibility of MSC-Exos for PCSD treatment is largely obscure. In this study, we took advantage of the in vivo myofibrotic model for mimicking the typical manifestation of PCSD and the assessment of fertility.

Inhalable nanovesicles loaded with a STING agonist enhance CAR-T cell activity against solid tumors in the lung.

Suppression of chimeric antigen receptor-modified T (CAR-T) cells by the immunosuppressive tumor microenvironment remains a major barrier to their efficacy against solid tumors. To address this, we develop an anti-PD-L1-expressing nanovesicle loaded with the STING agonist cGAMP (aPD-L1 NVs@cGAMP) to remodel the tumor microenvironment and thereby enhance CAR-T cell activity. Following pulmonary delivery, the nanovesicles rapidly accumulate in the lung and selectively deliver STING agonists to PD-L1-overexpressing cells via the PD-1/PD-L1 interaction.

Changing patterns of global nitrogen deposition driven by socio-economic development.

Advances in manufacturing and trade have reshaped global nitrogen deposition patterns, yet their dynamics and drivers remain unclear. Here, we compile a comprehensive global nitrogen deposition database spanning 1977-2021, aggregating 52,671 site-years of data from observation networks and published articles. This database show that global nitrogen deposition to land is 92.

The giant genome of lily provides insights into the hybridization of cultivated lilies.

Lilies are economically important monocots known for their ornamental flowers, bulbs, and large genomes. The absence of their genomic information has impeded evolutionary studies and genome-based breeding efforts. Here, we present reference genomes for Lilium sargentiae (lily, 35.

Spontaneous bifacial capping of perovskite film for efficient and mechanically stable flexible solar cell.

Flexible perovskite solar cells (F-PSCs) are appealing for their flexibility and high power-to-weight ratios. However, the fragile grain boundaries (GBs) in perovskite films can lead to stress and strain cracks under bending conditions, limiting the performance and stability of F-PSCs. Herein, we show that the perovskite film can facilely achieve in situ bifacial capping via introducing 4-(methoxy)benzylamine hydrobromide (MeOBABr) as the precursor additive.

Impact Assessment Through Interrupted Time Series: Divergent Influences of Stay-at-Home Order on Socioeconomically Disadvantaged Areas in NYC Shooting Incidents.

This study examines the impact of the COVID-19 pandemic and stay-at-home (SAH) orders on gun violence in New York City (NYC), with a focus on variations across neighborhood demographic and socioeconomic characteristics. Using a 4-year longitudinal and geospatial analysis, we investigate the relationship between socioeconomic factors (e.g.

Temporal and spatial variations of urinary phthalate metabolites for adults in China (2005-2020): A synthesis of biomonitoring data.

Chinese people are experiencing phthalate exposure risks. However, temporal and regional phthalate internal exposure variations amongst Chinese have not been established. To address this gap, we integrated our 69 adult participants' bio-monitored urinary phthalate metabolite (UPM) concentration data by high-performance liquid chromatography with mass spectrometry in Xi'an and Nanjing and the data from 35 literature (total sample size: 18768).

Cyclocurcumin potently inhibits human aromatase as a potential therapeutic agent.

Curcuminoids, including curcumin and its derivatives, show potent inhibition of aromatase (CYP19A1), crucial for estradiol synthesis and breast cancer metastasis. Our study evaluated the efficacy and mechanism of 10 curcuminoids and their metabolites against human and rat CYP19A1 using placental microsomes, revealing species-specific IC values. Cyclocurcumin (IC, 4.

Cold tolerance and prediction of northern distribution of Histia rhodope (Lepidoptera: Zygaenidae) in China.

Histia rhodope (Cramer) (Lepidoptera: Zygaenidae) is one of the most destructive defoliating pests of the landscape tree Bischofia polycarpa (Levl.) S in China and other Southeast Asian regions, posing a critical threat to urban landscapes and their ecological benefits. This pest has shown a trend of northward range shift in recent years in China, making it urgent to understand its potential distribution.

The Captopril Challenge Test Predicts Cardiac Structure and Dysfunction in Primary Aldosteronism.

Context: The captopril challenge test (CCT) is a commonly used confirmation test that identifies the magnitude of renin- and angiotensin II-independent aldosterone production, and thus the presence and severity of primary aldosteronism (PA).

Objective: This study investigated the association between the post-CCT plasma aldosterone concentration (PAC) and cardiovascular remodeling and diastolic dysfunction.

Methods: A total of 540 PA patients with complete CCT and echocardiographic data were retrospectively analyzed.

Adherence to positive airway pressure therapy in patients with Down syndrome: assessing cloud based monitoring data.

Study Objectives: Obstructive sleep apnea (OSA) is common in Down syndrome (DS) with many patients prescribed positive airway pressure (PAP) therapy. This study evaluates PAP adherence and identifies factors influencing adherence.

Methods: Retrospective analysis of electronic health records and cloud-based PAP therapy data from DS patients at Rady Children's Hospital, San Diego, CA.

Characteristics of viral ovarian tumor domain protease from two emerging orthonairoviruses and identification of Yezo virus human infections in northeastern China as early as 2012.

Emerging tick-borne orthonairovirus infections pose a growing global concern, with limited understanding of the viral ovarian tumor-like cysteine proteases (vOTUs) encoded by novel orthonairoviruses. These vOTUs, a group of deubiquinylases (DUBs), disrupt the innate immune response. Yezo virus (YEZV), a recently discovered pathogenic orthonairovirus, was first reported in Japan in 2021.

Supramolecular ionogels enable highly efficient electrochromism.

Ionogels are a promising solution to improve the functionality of electrochromic devices (ECDs) by solving issues related to traditional liquid electrolytes, such as volatility, toxicity, and leakage. However, manufacturing ionogels is complicated as it often involves cross-linking polymerization or chemical sol-gel processes, requiring large amounts of inorganic or polymeric gelators. This results in low ionic conductivity and poor ECD performance.

Preparation, structural characterisation, absorption and calcium transport studies of walnut peptide calcium chelate.

In this study, a walnut peptide (WP) with calcium-binding capacity was prepared using a combination of alkalase and neutrase. The conditions for the preparation of walnut peptide calcium chelate (WP-Ca) were optimised (a peptide/calcium chloride ratio of 1 : 4 for 70 min at 50 °C and pH 9.5).