Tungsten Carbide Embedded in a Porous Carbon Nanofiber Sandwich Structure Electrode: A Strategy to Improve the Performance of Lithium-Sulfur Batteries.

Lithium-sulfur (Li-S) batteries hold significant promise due to high energy density, cost-effectiveness, and ecological sustainability, but their practical applications are constrained by suboptimal electrochemical performance and the detrimental shuttle effect. Herein, a porous, sandwich-structured composite was developed to function as a freestanding cathode designed for Li-S batteries without aluminum foil. Porous carbon nanofibers (PCNF) were employed as the conductive matrix for sulfur, with tungsten carbide (WC) being incorporated to furnish abundant active sites for polysulfide adsorption.

A gated hydrophobic funnel within BAX binds long-chain alkenals to potentiate pro-apoptotic function.

Mitochondria maintain a biochemical environment that cooperates with BH3-only proteins (e.g., BIM) to potentiate BAX activation, the key event to initiate physiological and pharmacological forms of apoptosis.

Relationship between social support and depressive symptoms among internal migrant workers and the mediating role of healthy lifestyle: a cross-sectional study in China.

Objectives: To investigate the association between social support and depressive symptoms among internal migrant workers with a focus on the mediating role of a healthy lifestyle.

Design: Cross-sectional study.

Setting: The research was conducted among internal migrant workers in Henan Province, China, in August 2023.

From PD-1/PD-L1 to tertiary lymphoid structures: Paving the way for precision immunotherapy in cholangiocarcinoma treatment.

Cholangiocarcinoma (CCA) is a highly malignant hepatobiliary tumor characterized by limited treatment options and poor prognosis. The recent rise of immunotherapy has significantly influenced research in this field. This study presents a bibliometric analysis of 416 articles retrieved from the WOSCC, Wan fang Data, CNKI and VIP databases, spanning contributions from 32 countries, 589 institutions and 3,200 authors.

Insight on the optimized electronic structure of carbon nitride on ultrafast water treatment via photocatalytic activation of ferrate.

Ferrate (Fe(VI)) is a widely used water purifier and is easily affected by external factors. Given that the actual water environment conditions are complicated, this study designed an oxygen-doped carbon nitride (CNO) with rich electron sites to explore whether direct electron transfer promotes the degradation efficiency of Fe(VI) for pollutants under visible light. For comparison, we also prepared phosphorus-doped carbon nitride (CNP), which has electron-deficient sites and indirect electron transfer.

Harnessing the TAF1 Acetyltransferase for Targeted Acetylation of the Tumor Suppressor p53.

Pharmacological reactivation of the tumor suppressor p53 remains a key challenge for the treatment of cancer. Acetylation Targeting Chimera (AceTAC), a novel technology is previously reported that hijacks lysine acetyltransferases p300/CBP to acetylate the p53Y220C mutant. However, p300/CBP are the only acetyltransferases harnessed for AceTAC development to date.

Metabolic Adaptations To Acute Glucose Uptake Inhibition Converge Upon Mitochondrial Respiration For Leukemia Cell Survival.

One hallmark of cancer is the upregulation and dependency on glucose metabolism to fuel macromolecule biosynthesis and rapid proliferation. Despite significant pre-clinical effort to exploit this pathway, additional mechanistic insights are necessary to prioritize the diversity of metabolic adaptations upon acute loss of glucose metabolism. Here, we investigated a potent small molecule inhibitor to Class I glucose transporters, KL-11743, using glycolytic leukemia cell lines and patient-based model systems.

A Critical Perspective on Photothermal De-Icing.

To tackle the formidable challenges posed by extreme cold weather events, significant advancements have been made in developing functional surfaces capable of efficiently removing accreted ice. Nevertheless, many of these surfaces still require external energy input, such as electrical power, which raises concerns regarding their alignment with global sustainability goals. Over the past decade, increasing attention has been directed toward photothermal surface designs that harness solar energy-a resource available on Earth in quantities exceeding the total reserves of coal and oil combined.

Coinfection of avian hepatitis E virus and different serotypes of fowl adenovirus in chicken flocks in Shaanxi, China.

Unlabelled: In poultry, fowl adenovirus (FAdV) and co-infected viruses (such as avian hepatitis E virus, aHEV) are likely to cause decreased egg production, inclusion body hepatitis, and pericardial effusion syndrome. From July to September 2023, eight poultry farms of commercial broilers and commercial layers suffered from increased mortality, decreased egg production, and the presence of hydropericardium-hepatitis syndrome-like gross lesions in Shaanxi province, China. To determine the source of the infection, the viruses of aHEV, FAdV, avian leukosis virus (ALV), Marek's disease virus (MDV), Newcastle disease virus (NDV), and H9N2 avian influenza virus (AIV) were detected.

Interface Engineering of MOF Nanosheets for Accelerated Redox Kinetics in Lithium-Sulfur Batteries.

Modifying the separator is considered as an effective strategy for achieving high performance lithium-sulfur (Li-S) batteries. However, most modification layers are excessively thick, with catalytic active sites primarily located within the material's interior. This configuration severely impacts Li transport and the efficient catalytic conversion of polysulfides.

[Distribution, Accumulation Characteristics, and Risk Assessment of Heavy Metals in Vegetable Soils of Different Planting Years].

To ascertain the influence of prolonged planting on the distribution and accumulation of heavy metals in protected vegetable soil, samples from typical vegetable planting areas in Shenyang were gathered to evaluate the distribution features of Cr, Ni, Cu, Zn, Cd, and Pb in such soil. The Hakanson index, heavy metal risk assessment standard, and secondary phase to primary ratio methods were employed to evaluate the ecological hazard of soil in the research area, while the human health risk model was utilized to evaluate the health of inhabitants. The findings indicated that：① The amount of heavy metals Zn, Cr, Cu, Ni, Pb, and Cd in the topsoil （0~20 cm） of protected vegetable land in the study region decreased successively, and the content of heavy metals in the topsoil increased with the extension of planting years, of which Cd, Zn, and Cu increased most obviously, with maximum increases of 219%, 189%, and 134%, respectively.

Research Progress on Cyclic-Peptide Functionalized Nanoparticles for Tumor-Penetrating Delivery.

A key challenge in cancer treatment is the effective delivery of drugs into deep regions of tumor tissues, which are impermeable due to abnormal vascular network, increased interstitial fluid pressure (IFP), abundant extra cellular matrix (ECM), and heterogeneity of tumor cells. Cyclic peptides have been used for the surface engineering of nanoparticles to enhance the tumor-penetrating efficacy of drugs. Compared with other surface ligands, cyclic peptides are more easily produced by automated chemical synthesis, and they are featured by their higher binding affinity with their targets, tumor selectivity, stability against degradation, and low toxicity.

Compensatory eating disorder and full threshold DSM eating disorders: A comparison of eating-disorder-related psychiatric impairment and symptomatology.

Introduction: Compensatory eating disorder (CED) is a newly proposed 'other specified feeding and eating disorder' characterized by recurrent non-purging compensatory behaviors (e.g., compulsive exercise and/or food restriction), overvaluation of weight/shape, the absence of objective binge-eating episodes, and the absence of low weight or recent significant weight loss.

An immune-related gene pair signature predicts the prognosis and immunotherapeutic response in glioblastoma.

Background: Glioblastoma (GBM) has the feature of aggressive growth and high rates of recurrence. Immunotherapy was not included in standard therapy for GBM due to lacking the predictive biomarkers. In the present study, we performed an immune-related gene pair (IRGP) signature to predict the prognosis and immunotherapy response of GBM.

Integrating "Lumpers" versus "Splitters" Perspectives: Toward a Hierarchical Dimensional Taxonomy of Eating Disorders from Clinician Ratings.

This study describes a hierarchical dimensional model of eating-disorder (ED) classification based on the Hierarchical Taxonomy of Psychopathology (HiTOP). Participants were community-recruited adults with an ED (=252; 81.9% female).

Comparative Study on Morphological Features and Chemical Components of Wild and Cultivated Based on Bionic Technologies and Chemometrics.

As a traditional Chinese medicine, is primarily sourced from cultivated plants due to the significant decline in wild resources. This shift raises concerns about potential differences in efficacy resulting from variations in morphological features and chemical composition between wild (WA) and cultivated (CA) . In this study, a suite of advanced analytical techniques including electronic nose, electronic tongue, and electronic eye, alongside headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry and high-performance liquid chromatography, was applied to compare the morphological features and chemical components of WA and CA.

Primary robot-assisted laparoscopic partial nephrectomy for hemorrhage secondary to angiomyolipoma: a retrospective study from a large tertiary hospital in China.

With the continuous development of robot-assisted technology, Robot-assisted Laparoscopic Partial Nephrectomy (RALPN) has gradually become an optional method for the treatment of Hemorrhage secondary to angiomyolipoma (HSA). However, there are rare clinical reports of the primary RALPN for HSA. Therefore, this research aims to evaluate the efficacy and safety of primary RALPN for HSA.

Exogenous Janus Kinase 617 Codon Influences Small Noncoding RNAs and Gene Expression in Ba/F3 Cells.

Myeloproliferative neoplasms (MPNs) are blood cancers caused by mutations that originate from hematopoietic stem cells. More than 50%-90% of MPN patients had a dominant negative valine (V) to phenylalanine (F) mutation at the Janus kinase 617 codon (JAK2V617F) within the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway; however, this mutation was also found in a high percentage of the general population, its penetrance varied, and its onset was shown to be polygenic. Consequently, it is still unknown what molecular mechanism underlies the MPN transformation produced by JAK2V617F.

Negative Affect as a Mediator Between Exposure to Fitspiration and Thinspiration and Disordered Eating Behaviors: An Ecological Momentary Assessment Study.

Objective: Although social media use, such as Instagram, has been associated with ED pathology, mechanisms connecting social media use to disordered eating behaviors (DEBs) remain largely unevaluated. Based on Dual Process, Tripartite, and Affect Regulation models of ED pathology, we proposed a moderated mediation model evaluating impacts of exposure to fitspiration/thinspiration on Instagram.

Method: We evaluated a hypothesized pathway from exposure to fitspiration/thinspiration (i.

Transcriptome analysis of Reticulitermes flaviceps exposed to Mentha spicata essential oil and carvone indicates a potential neurotoxic mechanism of action characterized by intracellular calcium influx mediated by dopamine receptors.

Reticulitermes flaviceps is an economically important pest in agriculture, forestry, and construction. Recent studies have shown an increase in research focusing on the anti-termite properties of plant essential oils, however, there remains a lack of information regarding the specific molecular mechanism involved. In this study, RNA-seq analysis was conducted on termites exposed to Mentha spicata essential oil (EO) and carvone, leading to the discovery of various genes that were expressed differentially under different treatment conditions.

New clinical insights into the treatment of benign uretero-ileal anastomotic stricture following radical cystectomy and urinary diversion.

Background: Benign uretero-ileal anastomotic stricture (UIAS) is a potentially serious complication that can arise after radical cystectomy (RC) and subsequent urinary diversion. To preserve residual renal function and improve prognosis, it is crucial to derive insights from experience and tailor individualized treatment strategies for different patients.

Patients And Methods: From October 2014 to June 2021, a total of 47 patients with benign UIAS underwent endoscopic management (n = 19) or reimplantation surgery (n = 28).

The causal relationship between CSF metabolites and GBM: a two-sample mendelian randomization analysis.

Background: Glioblastoma multiforme (GBM) is a highly aggressive primary malignant brain tumor characterized by rapid progression, poor prognosis, and high mortality rates. Understanding the relationship between cerebrospinal fluid (CSF) metabolites and GBM is crucial for identifying potential biomarkers and pathways involved in the pathogenesis of this devastating disease.

Methods: In this study, Mendelian randomization (MR) analysis was employed to investigate the causal relationship between 338 CSF metabolites and GBM.

Evaluation of novel synthetic peptides of avian hepatitis E virus ORF2 as vaccine candidate in chickens.

Avian hepatitis E virus (HEV) has resulted in significant economic losses in the poultry industry. There is currently no commercial vaccination available to prevent avian HEV infection. Previously, a novel epitope (TFPS) was discovered in the ORF2 protein of avian HEV.

Field evaluation of oil crop rotations for cadmium remediation and safe vegetable oil production across five sites with varying contamination levels.

Oil crops have the potential to remediate cadmium (Cd)-contaminated farmland while producing safe vegetable oil. However, it is currently unknown whether different oil crops can remediate varying levels of Cd contamination in farmland. This study assessed agricultural fields in southern China contaminated with Cd levels ranging from 0.