Publications by authors named "Chen Yi-Chun"

This study evaluated the effectiveness of intraovarian platelet-rich plasma (PRP) injection in improving ovarian response and embryo quality in IVF patients with poor embryo quality in previous controlled ovarian hyperstimulation (COH) cycles. 74 patients participated, with 30 in the control group and 44 in the PRP group. PRP was injected during the follicular phase for the PRP group.

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Objectives: This study aimed to investigate the correlation of ovarian sensitivity index (OSI) and clinical parameters in IVF treatments.

Methods: IVF data files between January 2011 and December 2020 in a single unit were included. The primary outcome measure was the correlation between the OSI and clinical pregnancy and live birth rates.

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Purpose: To investigate the relationship between the characteristics of optic disc rotation and visual field (VF) progression in patients with myopic open-angle glaucoma (OAG).

Methods: We included 53 eyes from 53 myopic OAG patients who were followed-up over a 3-year period. The characteristics of optic disc rotation including the degree of optic disc rotation, direction of optic disc rotation, and optic disc rotation-VF defect correspondence were investigated.

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Purpose: Vitamin D supplementation positively impacts anemia, but the relationship between a ferritin-related dietary pattern, iron parameters, and vitamin D in anemia is unclear.

Methods: This cross-sectional study analyzed data from the 2017-2019 National Nutrition and Health Survey, including 1423 pregnant women over 15 years old. Dietary intake was assessed using a semi-quantitative food frequency questionnaire and a 24-hour dietary recall.

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In semiconducting monolayer transition metal dichalcogenides (ML-TMDs), broken inversion symmetry and strong spin-orbit coupling result in spin-valley lock-in effects so that the valley degeneracy may be lifted by external magnetic fields, potentially leading to real-space structural transformation. Here, magnetic field (B)-induced giant electric hysteretic responses to back-gate voltages are reported in ML-MoS field-effect transistors (FETs) on SiO/Si at temperatures < 20 K. The observed hysteresis increases with |B| up to 12 T and is tunable by varying the temperature.

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  • Carbon quantum dots (CQDs) are being studied for their biomedical applications, and this research assesses their safety and health risks based on different surface modifications.
  • The study examines three types of CQDs, highlighting variations in their physicochemical properties and biological impacts, particularly cytotoxicity, oxidative stress, and inflammation response.
  • Findings suggest that while some CQDs can induce cytotoxic effects and oxidative stress, they don't significantly harm renal integrity or cause organ damage in vivo, indicating their potential for safe use in biomedicine.
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  • This study investigates how the expression of prohormone convertase 1/3 (PC1/3), an enzyme crucial for processing peptide hormones, is affected in islet cells during the progression of type 1 and type 2 diabetes.
  • Researchers analyzed pancreatic samples from a diverse group of 54 donors, using immunostaining for detailed examination of PC1/3 in various islet cells at different diabetes stages.
  • The results revealed significant changes in islet cell morphology and reduced co-localization of PC1/3 with insulin in type 1 diabetes, while an increase in glucagon and somatostatin in these islets was also noted.
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Background: A causal connection between oxidative stress and inflammation in diabetes, along with its associated renal and cardiovascular complications, has been established. Sixteen prescribed potentially renoprotective Chinese herbal medicines for diabetic kidney disease (PRCHMDKD), which are scientific Chinese medicine (botanical drug) and categorized into five classes (clearing heat, nourishing yin, dampness dispelling, tonifying qi, and harmonizing formulas), exhibit shared antioxidative properties and target multiple oxidative stress pathways. However, the time-response, cumulative effects, and safety (hyperkalemia risk) of these sixteen PRCHMDKD on cardiorenal and survival outcomes in patients with overall and advanced DKD remain unresolved.

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  • This study examined how photoaging affects a nanoscale material called nZIF-8, focusing on its roles in oxidative stress and inflammation related to lung diseases.
  • Researchers found that prolonged exposure to sunlight caused significant changes in nZIF-8, reducing its size and altering its structure, which in turn decreased its toxic effects on lung cells.
  • The results suggest that aged nZIF-8 shows lower inflammatory responses and may reduce the risk of chronic obstructive pulmonary disease (COPD), emphasizing the importance of assessing the long-term safety of such materials.
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  • CD19-targeted CAR T cell therapies have transformed treatment for B-cell malignancies, but over half of patients face treatment failure due to antigen escape and low cell persistence.
  • The effectiveness of these therapies is impacted by cell functionality and potential toxicities from systemic cytokines.
  • A new virus-free engineering system, Quantum pBac™ (qPB), has been developed to produce dual-targeted CAR-T cells that are efficient, robust, and safe, potentially improving treatment effectiveness and accessibility.
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  • This study investigates how ferroelectric catalysts can change their catalytic activities by switching electric polarizations, using layered bismuth oxyselenide (L-BiOSe) microreactors.
  • It introduces a new method called selective-area ionic liquid gating to control the direction of dipole orientation in L-BiOSe, leading to variations in catalytic reactions, with upward polarization favoring oxygen evolution and downward polarization favoring hydrogen evolution.
  • The research demonstrates that by integrating L-BiOSe microreactors with different polarizations, it is possible to achieve overall water splitting, highlighting the potential for designing catalysts that can switch surface polarizations.
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Introduction: Sharing mental models is essential for high-performance teams, and speaking up is key for exchanging critical insights, especially during medical errors. Understanding how health providers and trainees voice their concerns is crucial for improving speaking-up behavior. This study aims to fill a gap in the literature by examining how medical students speak up when they encounter medical errors and assessing the impact of training on their speaking-up patterns.

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Purpose: Anti-granulocyte-macrophage colony-stimulating factor autoantibodies (anti-GM-CSF Abs) are implicated in the pathogenesis of Cryptococcus gattii (C. gattii) infection and pulmonary alveolar proteinosis (PAP). Their presence has also been noted in nocardiosis cases, particularly those with disseminated disease.

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Background: In Taiwan, COVID-19 outbreaks caused by the Omicron variant occurred in 2022. We investigated the incidence of candidemia during COVID-19 pandemic and the mortality of candidemia patients with COVID-19 in Taiwan.

Methods: The incidence of candidemia and fluconazole susceptibility of Candida species before (2015-2019) and during COVID-19 pandemic (2020-2023) at Kaohsiung Chang Gung Memorial Hospital were investigated.

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  • Recent research highlights the use of electronic polarizations, like ferroelectric and spin polarizations, to improve the efficiency of photocatalytic reactions, specifically for reducing carbon dioxide (CO).
  • The study focuses on a 2D layered crystal called copper indium thiophosphate (CuInPS), showing that controlling ferroelectric polarization through phase transitions and electrical poling significantly enhances CO reduction efficiency.
  • The research also investigates the role of spin electrons by introducing sulfur vacancies and applying a magnetic field to further boost CO reduction performance, utilizing advanced characterization techniques to understand these enhancements.
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Context: Limited evidence exists regarding the cumulative dosing and duration impact of renin-angiotensin system inhibitors (RASis) on cardiorenal and mortality outcomes in patients with advanced stages (predominantly in stage 5 and a minority in stage 4) of diabetic kidney disease (DKD).

Objective: To retrospectively investigate whether there are dose- and time-dependent relationships between RASis and cardiorenal and mortality outcomes in this population.

Methods: Using Taiwan's national health insurance data in 2000-2017, we analyzed 2196 RASi users and 2196 propensity-matched nonusers among 8738 patients living with diabetes and newly diagnosed with advanced chronic kidney disease (23% stage 4, 77% stage 5).

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Histoplasmosis is a global infection caused by the thermally dimorphic fungus, complex. It is endemic in the United States, as well as in Central and South America. In Taiwan, histoplasmosis is rare, with the first reported case not occurring until 1977.

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Background: The inherent problems in the existence of electron equilibrium and steep dose fall-off pose difficulties for small- and narrow-field dosimetry.

Objective: To investigate the cutout factors for keloid electron radiotherapy using various dosimetry detectors for small and narrow fields.

Method: The measurements were performed in a solid water phantom with nine different cutout shapes.

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In situ spectral reflectance initially captured at high spatial resolution with underwater hyperspectral imaging (UHI) is effective for classification and quantification in oceanic biogeochemical studies; however, the measured spectral radiance is rarely used as an absolute quantity due to challenges in calibration of UHI instruments. In this paper, a commercial UHI instrument was calibrated for radiometric flat field response and pixelwise immersion effect to support in situ measurement of absolute spectral radiance. The radiometric and immersion factor calibrations of the UHI instrument were evaluated quantitatively through comparative experiments with a spectroradiometer and a spectrometer.

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: To evaluate the effect of intrauterine infusion and hysteroscopic injection of autologous platelet-rich plasma (PRP) in patients with a persistent thin endometrium (EM) undergoing euploid frozen embryo transfer (EFET) cycles. : This prospective case-control study enrolled 116 infertile women with thin EM (<7 mm) who underwent hormone replacement therapy (HRT) for EFET. These women had experienced at least one previous unsuccessful EFET cycle, which either resulted in the cancellation of the cycle or failure of pregnancy.

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The pursuit of high-performance electronic devices has driven the research focus toward 2D semiconductors with high electron mobility and suitable band gaps. Previous studies have demonstrated that quasi-2D BiOSe (BOSe) has remarkable physical properties and is a promising candidate for further exploration. Building upon this foundation, the present work introduces a novel concept for achieving nonvolatile and reversible control of BOSe's electronic properties.

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Spin-to-charge conversion at the interface between magnetic materials and transition metal dichalcogenides has drawn great interest in the research efforts to develop fast and ultralow power consumption devices for spintronic applications. Here, we report room temperature observations of spin-to-charge conversion arising from the interface of NiFe (Py) and molybdenum disulfide (MoS). This phenomenon can be characterized by the inverse Edelstein effect length (λ), which is enhanced with decreasing MoS thicknesses, demonstrating the dominant role of spin-orbital coupling (SOC) in MoS.

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Understanding the magnetic and ferroelectric ordering of magnetoelectric multiferroic materials at the nanoscale necessitates a versatile imaging method with high spatial resolution. Here, soft X-ray ptychography is employed to simultaneously image the ferroelectric and antiferromagnetic domains in an 80 nm thin freestanding film of the room-temperature multiferroic BiFeO (BFO). The antiferromagnetic spin cycloid of period 64 nm is resolved by reconstructing the corresponding resonant elastic X-ray scattering in real space and visualized together with mosaic-like ferroelectric domains in a linear dichroic contrast image at the Fe L edge.

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  • In patients with repaired tetralogy of Fallot (rTOF), the regurgitant fraction (RF) is often unequal between the left and right pulmonary arteries, suggesting a link to vascular shape and size differences.
  • A study involving 79 rTOF patients and 20 healthy controls analyzed various factors, including blood flow dynamics and cardiac angles, revealing that rTOF patients had distinct vascular metrics compared to controls.
  • The findings indicate that the RF in the left pulmonary artery is typically worse and is associated with specific morphometric features, which could help inform future surgical approaches.
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