The sentinels of coronary artery disease: heterogeneous monocytes.

Monocytes are heterogeneous immune cells that play a crucial role in the inflammatory response during atherosclerosis, influencing the progression and outcome of the disease. In the pathogenesis of atherosclerotic diseases, such as coronary artery disease (CAD), monocytes not only serve as the initial sensors of endogenous and exogenous pathogenic factors, but also function as intermediators that bridge the circulatory system and localized lesions. In the bloodstream, heterogeneous monocytes, acting as sentinels, are rapidly recruited to atherosclerotic lesions, where they exhibit a heightened capacity to respond to various pathological stimuli upon detecting signals from damaged vascular endothelial cells.

Sour neuronal signalling attenuates macrophage mediated liver injury.

Background: Liver injury, a common pathophysiological basis of various liver diseases, is associated with inflammation. Hepatic nerves regulate inflammation. However, the specific signals that trigger inflammation and methods to treat inflammation by targeting nerves remain unknown.

Molecular docking- and reporter-based screening identify dicoumarol against ER stress-induced liver injury in mice through inhibiting IRE1α activity.

Aims: Drug-induced liver injury is among the most challenging liver disorders. Endoplasmic reticulum (ER) is responsible for the correct protein folding and secretion, which are highly active in hepatocytes. Failure in maintaining the proper protein folding under pathological condition or external stimuli leads to the unfolded protein response (UPR) to restore ER homeostasis or induce cell death.

Effects of Tweens on the Structure, interfacial Characteristics, and emulsifying and foaming properties of Ovalbumin.

Parameters such as interfacial tension, dynamics, and rheology are intricately linked to the emulsifying and foaming properties of proteins. In this study, the effects of different Tween types and concentrations on the structure and interfacial characteristics of ovalbumin (OVA) were examined, and their relationships with emulsifying and foaming properties were explored. The results showed that the addition of Tween caused the structure of OVA to become looser and more disordered (β-sheets gradually transformed into β-turns) and exposed more hydrophobic groups.

A band selection method combining spectral color characteristics for estimating chlorophyll content of rice in different backgrounds.

Spectroscopic technology is an effective method for estimating rice chlorophyll content. However, redundant spectral information and the complex background of rice in situ challenge the accuracy and robustness of the estimation. To address this problem, this study proposed a band selection method combining spectral color characteristics and established a convolutional neural network (CNN) model based on this method to estimate chlorophyll content of rice for black (background-free), clear, muddy, and green algae-covered backgrounds.

Predatory capacity of Lasioseius lindquisti (Acari: Blattisociidae) and Lasioseius scapulatus (Acari: Blattisociidae) on Megalurothrips usitatus (Thysanoptera: Thripidae).

Megalurothrips usitatus (Bagnall) (Thysanoptera: Thripidae) is an important pest of cowpeas, Vigna unguiculata (L.) Walp., and can cause severe damage to the crop.

Pre-arrest atrial fibrillation and neurological recovery after cardiac arrest among hospitalized patients: A retrospective cohort study.

Background: New-onset atrial fibrillation (AF) is associated with an increased risk of stroke in hospitalized patients with severe sepsis. Post-cardiac arrest patients experience conditions similar to sepsis. This study investigated whether pre-arrest AF is associated with poor neurological recovery following in-hospital cardiac arrest (IHCA).

Beta-aminoisobutyric acid improves bovine oocyte maturation and subsequent embryonic development by promoting lipid catabolism.

Energy metabolism homeostasis is essential for oocyte maturation and acquisition of developmental capacity. However, bovine oocyte in vitro maturation (IVM) is highly susceptible to metabolic stress and lipid accumulation. β-Aminoisobutyric acid (BAIBA), a metabolite produced in response to skeletal muscle exercise, has been reported to be involved in lipid and glucose metabolism, as well as inflammation and oxidative stress.

Colorimetric detection of glucose in food using gold nanoparticles as nanoenzymes combined with a portable smartphone-assisted microfluidic paper-based analysis device.

Glucose is an important source of energy for the human body, but excessive intake will destroy the body's metabolic balance and increase health risks. In this paper, a smartphone glucose colorimetric detection system was developed in a paper-based microfluidic analytical device (µPAD) using green synthetic gold nanoparticles (AuNPs) as probes for accurate, rapid and efficient quantitative analysis of glucose in food. The AuNPs, acting as mimetic enzymes, were capable of catalyzing the breakdown of HO generated by the interaction of glucose oxidase (GOx) with glucose to OH, which subsequently oxidized the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), resulting in a typical green reaction.

Patterning Composites Made of Rodlike and Bent-Core Molecules for Electric Applications.

Soft materials are ideal candidates for creating tunable, self-assembled architectures. Composite materials are elaborately designed with an unusual physical performance that combines solid nanostructures and orientationally ordered soft matter. Such composites can not only inherit properties of their constituents but also exhibit excellent conductivity.

Development and validation of a nomogram for circuit lifespan of regional citrate anticoagulation-continuous renal replacement therapy in intensive care patients with acute kidney injury.

Background: Regional citrate anticoagulation-continuous renal replacement therapy (RCA-CRRT) has a wide range of applications in clinical practice, but unplanned downtime due to RCA-CRRT circuit coagulation is as high as 15.75%-66.70%.

Transforming pediatric heart failure: Efficacy of low-dose sacubitril/valsartan.

Aims: Pediatric heart failure is a significant cause of illness and death in children. We aimed to assess sacubitril/valsartan's effectiveness and find the proper dosage for pediatric patients.

Methods: Patients unresponsive to traditional medicines for at least 12 months prescribed sacubitril/valsartan from January 2020 to March 2023 were reviewed.

Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived stem cell factor.

The abundance and biological contribution of natural killer (NK) cells in cancer are controversial. Here, we aim to uncover clinical relevance and cellular roles of NK cells in colon cancer liver metastasis (CCLM). Here, we integrated single-cell RNA-sequencing, spatial transcriptomics (ST), and bulk RNA-sequencing datasets to investigate NK cells' biological properties and functions in the microenvironment of primary and liver metastatic tumors.

Control Patterning of Cyanobiphenyl Liquid Crystals for Electricity Applications.

Controlling molecular self-assembly from organic solution evaporation is an important strategy for developing many functional materials and systems. In this work, it is demonstrated that 4-octyloxy-4'-cyanobiphenyl (8OCB) liquid crystals can be patterned into well-oriented stripes with very high micrometer-scale precision using a sandwich system through a dewetting method. The preparation temperature, concentration, and surface energy are combined to control the morphology and orientation of 8OCB microstripe arrays assisted by silicon micropillars.

Flexible piezoelectric materials and strain sensors for wearable electronics and artificial intelligence applications.

With the rapid development of artificial intelligence, the applications of flexible piezoelectric sensors in health monitoring and human-machine interaction have attracted increasing attention. Recent advances in flexible materials and fabrication technologies have promoted practical applications of wearable devices, enabling their assembly in various forms such as ultra-thin films, electronic skins and electronic tattoos. These piezoelectric sensors meet the requirements of high integration, miniaturization and low power consumption, while simultaneously maintaining their unique sensing performance advantages.

Multifunctional Radiation Conditioning Emitter for Laser and Infrared with Adaptive Radiative Cooling.

With the development of technology, multifunctional multiband emitters have been paid much attention due to their wide range of applications, such as LIDAR detection, spectroscopic sensing, and infrared thermal management. However, the development of such emitters is impeded by incompatible structural requirements of different electromagnetic wavebands. Here, we demonstrate coupled modulation between near-infrared (NIR) laser-wavelength and long-wavelength-infrared by constructing a multifunctional emitter (MFE) with a structure of Al/HfO/VO, utilizing the phase transition of VO.

Reversible Molecule Interactions Enable Ultrastretchable and Recyclable Ionogels for Wearable Piezoionic Sensors.

Ionogel-based piezoionic sensors feel motions and strains like human skin relying on reversible ion migrations under external mechanical stimulus and are of great importance to artificial intelligence. However, conventional ion-conductive polymers behave with degraded electrical and mechanical properties after thousands of strain cycles, and the discarded materials and devices become electronic wastes as well. Here, we develop ultrastretchable ionogels with superior electrical properties via the mediation of metal-organic frameworks, whose properties are attributed to reversible molecule interactions inside the material system.

Development of modern Chinese medicine guided by molecular compatibility theory.

Background: Traditional Chinese Medicine (TCM) has gained global attention, particularly after Professor Youyou Tu was awarded the Nobel Prize for her discovery of artemisinin as a treatment for malaria. However, the theory behind TCM is often perceived as a "black-box" with complex components and an unclear structure and mechanism of action. This had hindered the development of TCM within the framework of modern medicine.

A novel mechanism of ferroptosis inhibition-enhanced atherosclerotic plaque stability: YAP1 suppresses vascular smooth muscle cell ferroptosis through GLS1.

Atherosclerosis is a leading cause of cardiovascular diseases (CVDs), often resulting in major adverse cardiovascular events (MACEs), such as myocardial infarction and stroke due to the rupture or erosion of vulnerable plaques. Ferroptosis, an iron-dependent form of cell death, has been implicated in the development of atherosclerosis. Despite its involvement in CVDs, the specific role of ferroptosis in atherosclerotic plaque stability remains unclear.

Microvesicles from quiescent and TGF-β1 stimulated hepatic stellate cells: Divergent impact on hepatic vascular injury.

Background: This study evaluated the effect of microvesicles(MVs) from quiescent and TGF-β1 stimulated hepatic stellate cells (HSC-MVs, TGF-β1HSC-MVs) on H2O2-induced human umbilical vein endothelial cells (HUVECs) injury and CCl4-induced rat hepatic vascular injury.

Methods: HUVECs were exposed to hydrogen peroxide (H2O2) to establish a model for vascular endothelial cell injury. HSC-MVs or TGF-β1HSC-MVs were co-cultured with H2O2-treated HUVECs, respectively.

Chromosome-level genome assembly of Helwingia omeiensis: the first genome in the family Helwingiaceae.

Helwingia, a shrub of the monotypic cosmopolitan family Helwingiaceae, is distinguished by its inflorescence, in which flowers are borne on the midrib of the leaf-a trait not commonly observed in related plant families. Previous studies have investigated the development of this unusual structure using comparative anatomical methods. However, the scarcity of genomic data has hindered our understanding of the origins and evolutionary history of this uncommon trait at the molecular level.

Acetylation-dependent deubiquitinase USP26 stabilizes BAG3 to promote breast cancer progression.

Deubiquitylases (DUBs) have emerged as promising targets for cancer therapy due to their role in stabilizing substrate proteins within the ubiquitin machinery. Here, we identified ubiquitin-specific protease 26 (USP26) as an oncogene via screening prognostic DUBs in breast cancer. Through in vitro and in vivo experiments, we found that depletion of USP26 inhibited breast cancer cell proliferation and invasion, and suppressed tumor growth and metastasis in nude mice.

[Identification of cardioprotective substances in Panax ginseng/P. notoginseng based on mitochondrial morphological characteristics and UPLC-Triple-TOF-MS].

Panax ginseng is reputed to be capable of replenishing healthy Qi and bolstering physical strength, and P. notoginseng can resolve blood stasis and alleviate pain. P.