Publications by authors named "Chen Y"

The full utilization of lignocellulose involves two distinct catalytic routes: i) oxidative depolymerization of lignin and ii) acid/alkaline hydrolysis of hemicellulose and cellulose. To improve efficiency and reduce costs, constructing a single-cluster catalyst represents a desirable yet challenging strategy. Herein, triple-functional molecular polyoxometalates (POMs), NLLHVMoO (n = 1-6) were fabricated using N-lauroyl-l-lysine (NLL) and HVMoO as precursors.

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Background: Health-related rumors and misconceptions are spreading at an alarming rate, fueled by the rapid development of the internet and the exponential growth of social media platforms. This phenomenon has become a pressing global concern, as the dissemination of false information can have severe consequences, including widespread panic, social instability, and even public health crises.

Objective: The aim of the study is to compare the accuracy of rumor identification and the effectiveness of health science popularization between 2 generated large language models in Chinese (GPT-4 by OpenAI and Enhanced Representation through Knowledge Integration Bot [ERNIE Bot] 4.

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The integration of digital technologies into health care has significantly enhanced the efficiency and effectiveness of care coordination. Our perspective paper explores the digital information ecosystems in modern care coordination, focusing on the processes of information generation, updating, transmission, and exchange along a patient's care pathway. We identify several challenges within this ecosystem, including interoperability issues, information silos, hard-to-map patient care journeys, increased workload on health care professionals, coordination and communication gaps, and compliance with privacy regulations.

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Background: Chronic low back pain (CLBP) with sacroiliac joint (SIJ) involvement is a prevalent issue in health care. Surgical intervention, employing an endoscopic technique with a navigation system, targets and ablates nociceptive nerve fibers associated with SIJ pain, although the clinical effect of omitting rhizotomy of the lateral sacral branch of S3 remains uncertain.

Objectives: This study aimed to compare the clinical outcomes of 2 full-endoscopic rhizotomy and ablation (FERA) techniques for SIJ pain and to determine the effect of omitting rhizotomy of the lateral sacral branch of S3 on patient outcomes.

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Background: The neurolytic celiac plexus block (NCPB) can be introduced through the posterior para-aortic, anterior para-aortic, posterior transaortic, or endoscopic anterior para-aortic puncture approach, as well as the posterior approach via the intervertebral disc. To reduce the complications of puncture, this block's original manual blind puncture technique can be improved upon by using a C-arm fluoroscope, computed tomography (CT), or an ultrasound, the last of which may be endoscopic.

Objective: To observe the distribution of absolute alcohol and its analgesic effect on cancer-induced upper abdominal visceral pain during percutaneous NCPB through the anterior and posterior diaphragmatic crura under CT guidance.

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Background: Sex differences in blood pressure (BP) levels and hypertension are important and the role of socioeconomic status (SES) in sex differences in hypertension remains unclear.

Objective: This study aimed to evaluate the impact of SES on sex differences of hypertension in a nationally representative survey study.

Methods: A total of 98,658 participants aged ≥18 years who have lived in their current residence for ≥6 months were recruited from 162 study sites across mainland China.

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Background: In recent years, the frequent outbreaks of infectious diseases and insufficient emergency response capabilities, particularly issues exposed during the COVID-19 pandemic, have underscored the critical role of nurses in addressing public health crises. It is currently necessary to investigate the emergency preparedness of nursing personnel following the COVID-19 pandemic completely liberalized, aiming to identify weaknesses and optimize response strategies.

Objective: This study aimed to assess the emergency response competence of nurses, identify their specific training needs, and explore the various elements that impact their emergency response competence.

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Background: Understanding the impact of asthma on public health is crucial for evidence-based prevention and treatment strategies.

Objective: This study aimed to identify the causes of asthma-related mortality in Pudong, Shanghai, China, offering insights for managing similar regions or countries in transition.

Methods: Mortality statistics were obtained from the Vital Statistics System of Pudong for 2005-2021.

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Assessing the nutritional value of muscle food (MF) necessitates comprehensive component analysis. Traditional chemical analytical methods are often time-intensive, destructive, and environmentally detrimental, requiring specialized laboratory expertise. Hyperspectral imaging (HSI) emerges as an innovative technique that effectively integrates spectral and spatial information to enable rapid, nondestructive, and multidimensional predictions of nutritional parameters in MF.

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Microsatellite instability (MSI) is an important genomic biomarker for cancer diagnosis and treatment, and sequencing-based approaches are often applied to identify MSI because of its fastness and efficiency. These approaches, however, may fail to identify MSI on one or more sub-clones for certain cancers with a high degree of heterogeneity, leading to erroneous diagnoses and unsuitable treatments. Besides, the computational cost of identifying sub-clonal MSI can be exponentially increased when multiple sub-clones with different length distributions share MSI status.

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Tea plants are perennial evergreen woody crops that originated in low latitudes but have spread to high latitudes. Bud dormancy is an important adaptation mechanism to low temperatures, and its timing is economically significant for tea production. However, the core molecular networks regulating dormancy and bud break in tea plants remain unclear.

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  • - Therapeutic DNA cancer vaccines stimulate immune responses but often fall short in effectiveness; researchers found that manganese-doped silica nanoparticles (MSNA) can enhance these vaccines' performance.
  • - When combined with plasmid DNA encoding cancer antigens like α-fetoprotein, MSNA significantly increased specific immune responses in animal models, leading to better cancer immunity.
  • - The study showed that MSNA not only improved T cell responses against cancer but also successfully prevented tumor growth in models for both liver and HPV-related cancers.
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Building on the perspectives reflected in the Western intellectual tradition of the psychology of identity and the self, current research in cultural psychology tends to conceptualize uniqueness preferences as reflecting an identity-based motive and argues that people in Western cultures value uniqueness because it is viewed as inherently important to their identity and individuality. In this research, we introduce a complementary Eastern perspective to understand uniqueness preferences and argue that uniqueness preferences can also reflect a strategic motive where people in East Asian cultures may also value uniqueness because of the instrumental material and social benefits they believe uniqueness may confer. We tested our propositions in nine preregistered studies contrasting the decision making of people in the United States with those in China.

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  • - Huntington's disease (HD) is a genetic neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene, leading to the accumulation of harmful mutant proteins in nerve cells.
  • - The NLRP3 inflammasome plays a crucial role in inflammation and its overactivation contributes to neurodegeneration in HD; inhibiting it showed potential benefits in mice by reducing toxic inflammation and neuronal damage.
  • - Antcin-H, a compound derived from the medicinal fungus Antrodia cinnamomea, was found to decrease neuroinflammation and toxicity while improving motor function and survival rates in a mouse model of HD, indicating its potential as a therapeutic option.
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Purpose: To systematically synthesize the evidence on the effectiveness of electronic patient-reported outcome (ePRO)-based symptom management on readmission rate, quality of life, symptom burden, anxiety, depression, and mortality in adult cancer patients.

Method: A systematic review and meta-analysis were conducted according to the PRISMA guideline in PubMed, Web of Science, EMBASE, the Cochrane Library, CINAHL, and Scopus for studies of randomized controlled trials reporting ePRO-based symptom management from January 1st, 2018, to May 31st, 2023. Two reviewers independently assessed risk-of-bias using Cochrane Risk-of-Bias version 2 and extracted the data.

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  • The study investigates how plasma metabolites are linked to the progression of chronic kidney disease in individuals with type 2 diabetes, focusing on kidney function decline measured by eGFR slope.
  • Researchers analyzed data from over 5,000 people, identifying specific elevated levels of lipids and amino acids that influence kidney function, both positively and negatively.
  • The findings suggest that metabolite abnormalities, particularly related to fatty acids, may indicate issues with fat breakdown and are connected to the risk of worsening kidney health in diabetic patients.
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  • * Data was gathered from 300 neonates with HD, revealing that 6.0% (18) experienced bowel perforation, predominantly in the proximal ganglionic segment, with most cases involving short-segment (38.9%) or long-segment (50.0%) HD.
  • * All affected neonates underwent timely surgery, primarily stoma creation, which led to no reported deaths, although some faced postoperative complications like stoma retraction and bowel obstruction.
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Background: Metabolic-associated steatohepatitis (MASH) is one of the most prevalent liver diseases worldwide, with a global prevalence estimated between 3% and 5%, posing a significant health burden. Human liver organoids (HLOs) have previously been generated to model steatohepatitis, offering a potential cellular disease model for studying MASH. However, the current HLO model lacks detailed molecular characterizations and requires further improvement.

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  • ELMOD3 is a gene linked to a specific type of hearing loss but its role in tumors, particularly gastric cancer, is not well understood.
  • In experiments, turning off ELMOD3 in gastric cancer cells led to reduced growth, movement, invasion, and changes in how cells progress through their cycle.
  • The study suggests that ELMOD3 aids in tumor development by interacting with β-catenin, affecting various signaling pathways, and altering cell structure, positioning it as a potential target for cancer treatments.
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Chloroquine (CQ), initially introduced for the clinical treatment of malaria, has subsequently been found to exhibit beneficial effects in combating diabetes mellitus. The anti-hyperglycemic properties of chloroquine may be attributed to its anti-inflammatory response and its ability to activate the insulin signaling pathway. However, both animal and clinical studies have yielded mixed results.

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The process of "reading" and "writing" in biomemory involves the transmission of electrical signals between neurons, with ligand-gated ion channels assuming a key role. The solid-state nanochannels exhibit certain similarities with neurons. Information transmission can be achieved by controlling the flow of ions within nanochannels, rendering them potentially suitable for simulating neuron behavior.

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  • Intracerebral calcium deposition includes primary familial brain calcification (PFBC), which leads to motor decline, speech difficulties, and cognitive issues, with limited treatment options available.* -
  • Recent findings link PFBC to blood-brain barrier dysfunction, influenced by genetic variants that affect the neurovascular unit (NVU), leading to brain calcification.* -
  • The review examines literature on genetic mutations in cell junction proteins related to brain calcification, aiming to identify molecular pathways and support the need for molecular subtyping in understanding this condition.*
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