Roles of Copper Transport Systems Members in Breast Cancer.

Background: The occurrence and progression of breast cancer are closely linked to copper ion homeostasis. Both copper deficiency and excess can inhibit breast cancer growth, while copper transport systems may contribute to its progression by regulating copper ion transport and the activity of associated proteins. However, a comprehensive review of the roles and applications of copper transport systems in breast cancer remains limited.

Effects of Platycodon grandiflorum seeds exposure to static magnetic field on germination and early seedling growth.

Effects of non-uniform upward (north) and downward (south) 300 mT static magnetic field (SMF) 14 days (24 h/day) treatment of Platycodon grandiflorum seeds on germination, seedling growth, enzyme activities, malondialdehyde (MDA) level and seedling chlorophyll content were investigated under laboratory conditions. Germination rate, index and potential from magnetically exposed Anhui and Hebei Platycodon grandiflorum seeds were significantly not affected (p > 0.05), however, the values of these germination variables were notably higher in Anhui Platycodon grandiflorum seeds than Hebei seeds.

Synergistic antibacterial activity of baicalin in combination with oxacillin sodium against methicillin-resistant Staphylococcus aureus.

Methicillin-resistant Staphylococcus aureus (MRSA) poses a challenge for clinical treatment and combining antibiotics with other agents might be a promising strategy to overcome this challenge. This study explored the synergistic antibacterial activity of baicalin (traditional Chinese medicine extract) and the narrow-spectrum beta-lactam antibiotic oxacillin sodium, both of which are poorly active against MRSA in vitro. The combination of baicalin and oxacillin sodium showed a synergistic effect with a fractional inhibitory concentration index of 0.

Addition of SHR-1701 to first-line capecitabine and oxaliplatin (XELOX) plus bevacizumab for unresectable metastatic colorectal cancer.

This phase 2/3 trial (NCT04856787) assessed the efficacy and safety of SHR-1701, a bifunctional protein targeting PD-L1 and TGF-β, in combination with BP102 (a bevacizumab biosimilar) and XELOX (capecitabine plus oxaliplatin) as a first-line treatment for unresectable metastatic colorectal cancer (mCRC). In this phase 2 study, a total of 62 patients with untreated, histologically confirmed colorectal adenocarcinoma and no prior systemic therapy for metastatic disease were enrolled. Patients received SHR-1701 (30 mg/kg), bevacizumab (7.

Impact of stage 1 hypertension before 20 gestational weeks on pregnancy outcomes in twin pregnancies: a retrospective cohort study.

To explore the association between stage 1 hypertension before 20 weeks of gestation and twin pregnancy outcomes and to examine whether the association varies by prepregnancy BMI, conception mode, or chorionicity, we conducted a single-center, retrospective, hospital-based cohort study. All women who delivered twins between July 2014 and December 2020 were recruited. Logistic regression and linear regression models were used to identify associations.

Association of Cigarette Consumption and Mucosal Thickening in the Paranasal Sinuses on MRI.

Objective: To investigate the impact of cigarette consumption on mucosal thickening in paranasal sinuses and the relationships of smoking-related factors and dental status with mucosal thickening at different maxillary sinus locations using MRI.

Materials And Methods: This retrospective study investigated 1094 paranasal sinuses on MRIs by correlating mucosal thickening with smoking-related factors. Presence/absence of maxillary posterior teeth was correlated with mucosal thickening on the maxillary sinus floor and other sinus locations.

The molecular mechanism of Xiaoyaosan in treating major depressive disorder: Integrated analysis of DNA methylation and RNA sequencing of the arcuate nucleus in rats.

Ethnopharmacological Relevance: Xiaoyaosan, a classic Chinese herbal formula, exhibits promising antidepressant effects. However, its specific antidepressant mechanisms remain incompletely understood. Previous studies have highlighted the significant role of DNA methylation in the pathogenesis of major depressive disorder (MDD).

Evidences of the Electrogenic Sulfur Oxidation in Constructed Wetlands.

The sulfur redox cycling, mainly involving sulfide oxidation and sulfate reduction, remains a crucial factor that regulates the treatment performance of constructed wetlands (CWs). However, anoxic environments normally prevail in the CW systems, harboring vast reduced sulfur and sulfur minerals, where the occurrence and mechanism of anoxic sulfide oxidation remain unknown. In this study, CW microcosms filled with quartz sand (Qtz) and pyrite (Pyt) were established to investigate the anoxic sulfur oxidation under the bioelectrochemical manipulations.

Urinary concentrations of eighteen environmental phenols and the associations with feeding pattern in infants in the first 6 months of life.

Environmental phenols are a group of typical endocrine disruptors, and widely detectable in human breast milk and infant formulas. However, exposures data are scarce in early infancy, a particularly sensitive period to environmental pollutants exposures. We aimed to prospectively assess urinary concentrations of eighteen environmental phenols in infants from birth to 6 months of age and their associations with feeding patterns (breastfeeding, formula and mixed-feeding).

Directed coordination of C/N-termini of cyano group in metal hexacyanoferrates to efficient palladium recovery: Enhanced adsorption affinity and selectivity.

N-termini Cyano group (CN) in metal hexacyanoferrates (MHCF) have been identified as specific-affinity sites for palladium (Pd), but C-termini CN do not effectively serve as Pd adsorption sites due to their stronger bonds with the metal ligands (M), which reduces the activity and density of CN. Herein, the optimization of directional coordination of cyano group C/N-termini by modulating the electronic structure of the M (Fe, Co, and Ni) in MHCF was investigated to reinforce the Pd recovery. Spectroscopic analyses and DFT calculations revealed that NiHCF exhibited N-site mono-coordination, whereas CoHCF displayed C-site mono-coordination due to spin-exchange interactions, leading to the strengthened N-Co bonds and weakened Fe-C bonds.

Proteomic and spectral analysis reveals the role of extracellular polymeric substances in mercury biosorption by activated sludge under high-altitude conditions.

In high-altitude regions, elevated mercury (Hg) levels in wastewater treatment plants (WWTPs) influent raise concerns about treatment efficiency and environmental impact. This study investigated the Hg biosorption capacity of activated sludge under high-altitude conditions, focusing on the binding mechanisms between EPS and Hg, and variations in EPS secretion. Low pressure, oxygen, and temperature at high altitudes increase EPS secretion, enhancing Hg biosorption.

Phlecarinatones H-N: Abietane-type diterpenoids from Phlegmariurus carinatus with proliferative inhibitory effect on U251 glioblastoma cells.

Thirteen abietane-type diterpenoids, including seven previously undescribed compounds and six known analogs, were isolated from the root and aerial parts of Phlegmariurus carinatus. Their structures were elucidated by comprehensive spectroscopic data analysis (UV, IR, NMR, and HRESIMS) and quantum chemical calculations (calculated ECD or C NMR). Notably, these compounds exhibited high structural diversity.

Nanoparticle-enabled In Situ drug potency activation for enhanced tumor-specific therapy.

Cancer treatment faces significant challenges including inadequate tumor specificity, drug resistance, and severe side effects, often resulting in unsatisfactory patient outcomes. Nanomedicines offer a transformative platform for tumor-targeted drug delivery and antitumor potency activation, providing an indispensable strategy for overcoming the severe damage to normal tissues caused by the inherent "always-on" cytotoxicity of conventional therapeutic agents. This review focuses on the emerging concept of "nanoparticle-enabled in situ drug potency activation", where inactive or minimally toxic agents are selectively activated within tumors to enhance the therapeutic efficacy and minimize the adverse effects.

Deficiency of EXT1 and FGFR3 genes promotes chondrocyte differentiation, leading to the induction of osteochondroma formation.

Objective: This study aims to investigate the roles of the EXT1 and FGFR3 genes in the development of osteochondromas, focusing specifically on their potential interactions in chondrocyte proliferation, differentiation, and tumor formation.

Methods: In vitro, the ATDC5 chondroprogenitor cell line was used to examine the effects of inactivation of both EXT1 and FGFR3. In vivo, a mouse model with dual gene knockout of Ext1 and Fgfr3 was constructed to further explore these genes' roles in tumor formation by observing the incidence and distribution patterns of osteochondromas.

The prevalence of occult malignancy in women undergoing hysterectomy or myomectomy for benign indications and the impact of morcellation on survival outcomes: a meta-analysis.

Introduction Uterine fibroids (UFs), also known as leiomyomas, are the most common benign gynecological tumors. Currently, morcellation is discouraged owing to the risk of disseminating undetected malignancies. This study aims to update the prevalence data on occult malignancies in surgeries for suspected benign uterine lesions and analyze the impact of treatment strategies on survival outcomes in patients with occult malignancies.

Effect of long-term exposure to non-biodegradable and biodegradable microplastics in continuous anoxic/aerobic bioreactors: Nitrogen removal performance, microbial communities and functional gene responses.

The environmental hazards caused by microplastics (MPs) have received widespread attention, but the effects of non-biodegradable and biodegradable MPs of long-term presence on continuously operating sewage treatment bioreactors are not well known. In this study, we investigated the effect of a representative non-biodegradable MP, polyethylene terephthalate (PET), and a biodegradable MP, polylactic acid (PLA), on the nitrogen removal performance of conventional anoxic/aerobic (A/O) process. The NH-N removal efficiencies were suppressed to 91.

Optimizing the gelation, structure, and thermal stability of alkali-induced duck egg white gels with calcium chloride.

Alkali treatment is a proven method for producing transparent elastic protein gels and could provide a practical way to utilize surplus duck egg whites that are generated during processing. However, this method often leads to gel liquefaction and structural instability. The addition of metal cations at appropriate concentrations can enhance the stability and strength of the gels and prevent liquefaction.

Transcriptional and molecular simulation analysis of the response mechanism of anammox bacteria to 3,4-dimethylpyrazole phosphate stress.

Anaerobic ammonium oxidation (anammox) and nitrification are two vital biological pathways for ammonium oxidation, pivotal in microbial nitrogen cycling. 3,4-Dimethylpyrazole phosphate (DMPP) is commonly used as inhibitors in agricultural soils to reduce nitrogen losses from farmland, while whether it affect anammox is an open question. Acute inhibition tests revealed that 53.

Association of blood cadmium and physical activity with mortality: A prospective cohort study.

Physical activity (PA) may be considered an alternative method to ameliorate the elevated mortality risks associated with cadmium exposure. In this prospective cohort study, a total of 20,253 participants (weighted mean age, 47.79 years), including 10,247 men (weighted prevalence: 50.

Trends in Firearm Injuries Treated in Emergency Departments by Individual- and County-Level Characteristics, 2019 to 2023.

Study Objective: To understand trends in nonfatal firearm injuries by examining rates of firearm injury emergency department (ED) visits stratified by individual- and county-level characteristics.

Methods: Data from participating EDs within 10 jurisdictions in the United States funded through the Centers for Disease Control and Prevention's Firearm Injury Surveillance Through Emergency Rooms program, including the District of Columbia, Florida, Georgia, New Mexico, North Carolina, Oregon, Utah, Virginia, Washington, and West Virginia, were analyzed. We examined trends in firearm injury ED visits by sex, age group, jurisdiction, county-level urbanicity, and county-level social vulnerability from January 2019 to August 2023.

Effects of Rhodopseudomonas palustris and composite probiotics on growth performance, intestinal health, and non-specific immunity of sea urchin (Strongylocentrotus intermedius).

In recent decades, antibiotics have been widely used in sea urchin aquaculture to prevent diseases and improve water quality. However, their use leads to the emergence of resistant strains and environmental problems. Probiotics can serve as a green and pollution-free alternative.