CircXPO6 promotes breast cancer progression through competitively inhibiting the ubiquitination degradation of c-Myc.

The number of breast cancer (BC) patients is increasing year by year, which is severely endangering to human life and health. c-Myc is a transcription factor, studies have shown that it is a very significant factor in tumor progression, but how it is regulated in BC is still not well understood. Here, we used the RIP microarray sequencing to confirm circXPO6, which had a high affinity with c-Myc and highly expressed in triple-negative breast cancer (TNBC) tissues and cells.

Clamping enables enhanced electromechanical responses in antiferroelectric thin films.

Thin-film materials with large electromechanical responses are fundamental enablers of next-generation micro-/nano-electromechanical applications. Conventional electromechanical materials (for example, ferroelectrics and relaxors), however, exhibit severely degraded responses when scaled down to submicrometre-thick films due to substrate constraints (clamping). This limitation is overcome, and substantial electromechanical responses in antiferroelectric thin films are achieved through an unconventional coupling of the field-induced antiferroelectric-to-ferroelectric phase transition and the substrate constraints.

Antiferromagnetic magnonic charge current generation via ultrafast optical excitation.

Néel spin-orbit torque allows a charge current pulse to efficiently manipulate the Néel vector in antiferromagnets, which offers a unique opportunity for ultrahigh density information storage with high speed. However, the reciprocal process of Néel spin-orbit torque, the generation of ultrafast charge current in antiferromagnets has not been demonstrated. Here, we show the experimental observation of charge current generation in antiferromagnetic metallic MnAu thin films using ultrafast optical excitation.

Spin disorder control of topological spin texture.

Stabilization of topological spin textures in layered magnets has the potential to drive the development of advanced low-dimensional spintronics devices. However, achieving reliable and flexible manipulation of the topological spin textures beyond skyrmion in a two-dimensional magnet system remains challenging. Here, we demonstrate the introduction of magnetic iron atoms between the van der Waals gap of a layered magnet, FeGaTe, to modify local anisotropic magnetic interactions.

Manipulating chiral spin transport with ferroelectric polarization.

A magnon is a collective excitation of the spin structure in a magnetic insulator and can transmit spin angular momentum with negligible dissipation. This quantum of a spin wave has always been manipulated through magnetic dipoles (that is, by breaking time-reversal symmetry). Here we report the experimental observation of chiral spin transport in multiferroic BiFeO and its control by reversing the ferroelectric polarization (that is, by breaking spatial inversion symmetry).

Switching the spin cycloid in BiFeO with an electric field.

Bismuth ferrite (BiFeO) is a multiferroic material that exhibits both ferroelectricity and canted antiferromagnetism at room temperature, making it a unique candidate in the development of electric-field controllable magnetic devices. The magnetic moments in BiFeO are arranged into a spin cycloid, resulting in unique magnetic properties which are tied to the ferroelectric order. Previous understanding of this coupling has relied on average, mesoscale measurements.

Electrical 180° switching of Néel vector in spin-splitting antiferromagnet.

Antiferromagnetic spintronics have attracted wide attention due to its great potential in constructing ultradense and ultrafast antiferromagnetic memory that suits modern high-performance information technology. The electrical 180° switching of Néel vector is a long-term goal for developing electrical-controllable antiferromagnetic memory with opposite Néel vectors as binary "0" and "1." However, the state-of-art antiferromagnetic switching mechanisms have long been limited for 90° or 120° switching of Néel vector, which unavoidably require multiple writing channels that contradict ultradense integration.

Room-Temperature, Current-Induced Magnetization Self-Switching in A Van Der Waals Ferromagnet.

2D layered materials with broken inversion symmetry are being extensively pursued as  spin source layers to realize high-efficiency magnetic switching. Such low-symmetry layered systems are, however, scarce. In addition, most layered magnets with perpendicular magnetic anisotropy show a low Curie temperature.

Octupole-driven magnetoresistance in an antiferromagnetic tunnel junction.

The tunnelling electric current passing through a magnetic tunnel junction (MTJ) is strongly dependent on the relative orientation of magnetizations in ferromagnetic electrodes sandwiching an insulating barrier, rendering efficient readout of spintronics devices. Thus, tunnelling magnetoresistance (TMR) is considered to be proportional to spin polarization at the interface and, to date, has been studied primarily in ferromagnets. Here we report observation of TMR in an all-antiferromagnetic tunnel junction consisting of MnSn/MgO/MnSn (ref.

Spin homojunction with high interfacial transparency for efficient spin-charge conversion.

High interfacial transparency is vital to achieve efficient spin-charge conversion for ideal spintronic devices with low energy consumption. However, in traditional ferromagnetic/nonmagnetic heterojunctions, the interfacial Rashba spin-orbit coupling brings about spin memory loss (SML) and two-magnon scattering (TMS), quenching spin current crossing the heterointerfaces. To address the intrinsic deficiency of heterointerface, we design a ferromagnetic FeRh/antiferromagnetic FeRh spin homojunction for efficient spin-charge conversion, verified by a high interfacial transparency of 0.

Perpendicular full switching of chiral antiferromagnetic order by current.

Electrical control of a magnetic state of matter lays the foundation for information technologies and for understanding of spintronic phenomena. Spin-orbit torque provides an efficient mechanism for the electrical manipulation of magnetic orders. In particular, spin-orbit torque switching of perpendicular magnetization in nanoscale ferromagnetic bits has enabled the development of stable, reliable and low-power memories and computation.

Tumor Deposits and Perineural Invasion had Comparable Impacts on the Survival of Patients With Non-metastatic Colorectal Adenocarcinoma: A Population-Based Propensity Score Matching and Competing Risk Analysis.

Background: Both tumor deposits (TD) and perineural invasion (PNI) have been identified as risk factors for poor survival in patients with non-metastatic colorectal adenocarcinoma (CRC). However, the adverse impacts of TD and PNI on the survival of patients with non-metastatic CRC have not been compared.

Method: Patients with non-metastatic CRC with known TD and PNI status were selected from the Surveillance, Epidemiology, and End Results (SEER) database.

The Influence of Entrepreneurial Policy on Entrepreneurial Willingness of Students: The Mediating Effect of Entrepreneurship Education and the Regulating Effect of Entrepreneurship Capital.

With the transformation and development of the social economy of the country, innovation, and entrepreneurship have been a wide concern in all sectors of the society. In contrast, the entrepreneurial success rate of college students in China is low, and the willingness of students to start a business is generally not high. As a leading element, entrepreneurship policy plays an important role in creating an enabling social environment for entrepreneurship and promoting innovation and entrepreneurship.

Observation of the antiferromagnetic spin Hall effect.

The discovery of the spin Hall effect enabled the efficient generation and manipulation of the spin current. More recently, the magnetic spin Hall effect was observed in non-collinear antiferromagnets, where the spin conservation is broken due to the non-collinear spin configuration. This provides a unique opportunity to control the spin current and relevant device performance with controllable magnetization.

Long-term oncological outcomes of low anterior resection for rectal cancer with and without preservation of the left colic artery: a retrospective cohort study.

Background: There is uncertainty in the literature about preserving the left colic artery (LCA) during low anterior resection for rectal cancer. We analyzed the effect of preserving the LCA on long-term oncological outcomes.

Methods: We retrospectively collected clinicopathological and follow-up details of patients who underwent low anterior resection for rectal cancer in the General Surgery Department of Guangdong Provincial People's Hospital, from January 2014 to December 2015.

Fabrication of pH-sensitive graphene oxide-Benazepril carrier as biosafety controlled release systems.

A novel graphene oxide (GO)-based carrier was fabricated for the controlled release of Benazepril (BENA). Freeze dried samples of GO-BENA carrier were prepared for controlled drug release at different pHs (pH = 2, 7, and 10) and release kinetics indicate BENA desorption from GO is by Fickian diffusion. The BENA yield from the carrier amounted to ~55% of the adsorbed material in a strongly acidic medium after 50 h.

Survival outcome of palliative primary tumor resection for colorectal cancer patients with synchronous liver and/or lung metastases: A retrospective cohort study in the SEER database by propensity score matching analysis.

Background: There is a great matter of controversies whether some of these synchronous metastatic colorectal cancer patients can benefit from palliative primary tumor resection (pPTR) and there is still no reported randomized control trial to address this issue.

Methods: Patients with microscopically proven metastatic colorectal cancer were identified within the SEER database (2010-2016). Patients were propensity matched 1:1 into pPTR and non-surgery groups and among the matched cohort, the univariable and multivariable Cox proportional hazards regression models were performed to identify predictors of survival.

Realization of Isolated and High-Density Skyrmions at Room Temperature in Uncompensated Synthetic Antiferromagnets.

Magnetic skyrmions are vortex-like spin textures with nontrivial spin topology and novel physical properties that show promise as an essential building block for novel spintronic applications. Skyrmions in synthetic antiferromagnets (SAF) have been proposed long-term to have many advantages than those in ferromagnetic materials, which suffer from fundamental limits for size and efficient manipulation. Thus, experimental realization of skyrmions in SAF is intensely pursued.

Amplified Analysis of DNA or Proteins by TdT-generated DNAzyme.

Sensitive and specific detection of nucleic acids or proteins, which act as biomarkers, is of great importance in disease diagnosis. By combing the concept and operation of an endonuclease-assisted target-responsive amplification method and peroxidase-mimic DNAzyme generated by terminal deoxynucleotidyl transferase (TdT), a novel and facile colorimetric biosensor was developed for DNA and protein. Target DNA and thrombin were chosen as representative biomolecules.

Spin pumping during the antiferromagnetic-ferromagnetic phase transition of iron-rhodium.

FeRh attracts intensive interest in antiferromagnetic (AFM) spintronics due to its first-order phase transition between the AFM and ferromagnetic (FM) phase, which is unique for exploring spin dynamics in coexisting phases. Here, we report lateral spin pumping by which angular momentum is transferred from FM domains into the AFM matrix during the phase transition of ultrathin FeRh films. In addition, FeRh is verified to be both an efficient spin generator and an efficient spin sink, by electrically probing vertical spin pumping from FM-FeRh into Pt and from Py into FeRh, respectively.

Layer-by-Layer Fabrication of Core-Shell FeO@UiO-66-NH with High Catalytic Reactivity toward the Hydrolysis of Chemical Warfare Agent Simulants.

Detoxifying materials against chemical warfare agents (CWAs) and their simulants are highly desired for proper handling of contamination by and destruction of CWAs. Herein, we report a facile layer-by-layer fabrication of core-shell FeO@UiO-66-NH and its application in fast degradation of CWA simulants. The FeO@UiO-66-NH composite was prepared through a layer-by-layer epitaxial growth strategy, by alternately immersing FeO nanoparticles in ethanol solutions of a metal node [ZrO(OH)] precursor and organic linkers [NH-BDC, 2-aminoterephthalic acid], respectively, and separating using a magnet.

Electric field control of Néel spin-orbit torque in an antiferromagnet.

Electric field control of spin-orbit torque in ferromagnets has been intensively pursued in spintronics to achieve efficient memory and computing devices with ultralow energy consumption. Compared with ferromagnets, antiferromagnets have huge potential in high-density information storage because of their ultrafast spin dynamics and vanishingly small stray field. However, the manipulation of spin-orbit torque in antiferromagnets using electric fields remains elusive.

Construction of a Biosensor Based on a Combination of Cytochrome , Graphene, and Gold Nanoparticles.

A biosensor based on a combination of cytochrome (Cyt ), electrochemical reduced graphene oxides (ERGO), and gold nanoparticles (AuNPs) on a glassy carbon electrode (GCE) was fabricated. The proposed biosensor electrode was denoted as GCE/ERGO-Nafion/AuNPs/Cyt /Nafion, where ERGO-Nafion was deposited by dropping graphene oxides-Nafion mixed droplet first and following electrochemical reduction, AuNPs were directly deposited on the surface of the ERGO-Nafion modified electrode by electrochemical reduction, and other components were deposited by the dropping-dry method. The effect of the deposition amount of AuNPs on direct electrochemistry of Cyt in the proposed electrode was investigated.

Dopamine Assisted One-Step Pyrolysis of Glucose for the Preparation of Porous Carbon with A High Surface Area.

Herein, a facile dopamine assisted one-pot synthesis approach is proposed for the preparation of porous carbon with a specific surface area (SSA) up to 2593 m²/g through the direct pyrolysis of a mixture of glucose, NH₄Cl, and dopamine hydrochloride (DAH). The glucose is adopted as the carbon source and foaming agent, NH₄Cl is used as the blowing agent, and DAH is served as collaborative carbon precursor as well as the nitrogen source for the first time. The effect of dopamine on the component, structure, and SSA of the as-prepared porous carbon materials are systematically studied.

Gastric Cancer Screening by Combined Determination of Serum Antibody and Pepsinogen Concentrations: ABC Method for Gastric Cancer Screening.

Objective: Gastroscopy combined with gastric mucosa biopsies is currently regarded as a gold standard for diagnosis of gastric cancer. However, its application is restricted in clinical practice due to its invasive property. A new noninvasive population screening process combining the assay of anti-Helicobacter pylori antibody and serum pepsinogen (PG) (ABC method) is adopted to recognize the high-risk patients for further endoscopy examination, avoiding the unnecessary gastroscopy for most population and saving the cost consumption for mass screening annually.