Publications by authors named "Chen Xiabo"
Background: Wenshen Jianpi recipe (WSJPR), a blended traditional Chinese medicine, is considered to have the possible beneficial effect on the progression of diabetic nephropathy (DN). This present study was designed to elucidate this protective activity in a rat model with streptozotocin (STZ)-induced DN and to explore the possible underlying mechanism.
Methods: Adult Sprague Dawley (SD) rats were induced to develop DN through intraperitoneal injection of STZ (60 mg/kg).
Notoginsenoside R1 alleviates TNF-α-induced pancreatic β-cell Min6 apoptosis and dysfunction through up-regulation of miR-29a.
Artif Cells Nanomed Biotechnol
December 2019
Diabetes mellitus (DM) is a metabolic disorder that seriously harms human health. Notoginsenoside R1 (NGR1) can be used in various diseases. We explored consequents of NGR1 on tumour necrosis factor (TNF)-α-stimulated Min6 and rat primary islets β cells.
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- The study investigates pancreatic lipidosis (NAFPD) in a Chinese adult population, finding an overall prevalence of 11.05% that increases with age.
- Key risk factors for developing NAFPD include nonalcoholic fatty liver disease (NAFLD), type 2 diabetes mellitus (T2DM), and markers of insulin resistance and dyslipidemia.
- Severe NAFPD is particularly linked with NAFLD and dyslipidemia, highlighting the importance of these conditions in the disease's progression.